Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
권호 표지
DOI QR코드

DOI QR Code

Feasibility Study on Magnetic Nanoparticle Hyperthermia in Low Field MRI

저자장 자기공명영상 시스템 내에서 초상자성 나노입자 온열치료를 위한 발열 평가

  • Kim, Ki Soo (Department of Biomedical Engineering, Kyung Hee University) ;
  • Cho, Min Hyoung (Department of Biomedical Engineering, Kyung Hee University) ;
  • Lee, Soo Yeol (Department of Biomedical Engineering, Kyung Hee University)
  • 김기수 (경희대학교 생체의공학과) ;
  • 조민형 (경희대학교 생체의공학과) ;
  • 이수열 (경희대학교 생체의공학과)
  • Received : 2014.07.17
  • Accepted : 2014.08.20
  • Published : 2014.08.30
Download PDF
⟨ Previous Next ⟩

Abstract

For the combination of MRI and magnetic particle hyperthermia(MPH), we investigated the relative heating efficiency with respect to the strength of the static magnetic field under which the magnetic nanoparticles are to be heated by RF magnetic field. We performed nanoparticle heating experiments at the fringe field of 3T MRI magnet with applying the RF magnetic field perpendicularly to the static magnetic field. The static field strengths were 0T, 0.1T, 0.2T, and 0.3T. To prevent the coil heat from conducting to the nanoparticle suspension, we cooled the heating solenoid coil with temperature-controlled water with applying heat insulators between the solenoid coil and the nanoparticle container. We observed significant decrease of heat generation, up to 6% at 0.3T(100% at 0T), due to the magnetic saturation of the nanoparticles of 15 nm diameter under the static field. We think MPH is still feasible at low magnetic field lower than 0.3T if stronger RF magnetic field generation is permitted.

Keywords

References

  1. J.L. Corchero and A. Villaverde, "Biomedical applications of distally controlled magnetic nanoparticles," Trends Biotechnol., vol. 27, pp. 468-476, 2009. https://doi.org/10.1016/j.tibtech.2009.04.003
  2. S. Laurent, D. Forge, M. Port, A. Roch, C. Robic, L. vander Elst, and R.N. Muller "Magnetic iron oxide nanoparticle: synthesis, stabilization, vectorization, physicochemical characterizations and biological applications," Chem. Rev., vol. 108, pp. 2064-2110, 2008. https://doi.org/10.1021/cr068445e
  3. S. Mornet, S. Vasseur, F. Grasset, and E. Duguet, "Magnetic nanoparticle design for medical diagnosis and therapy," J. Mater. Chem., vol. 14, pp. 2161-2175, 2004. https://doi.org/10.1039/b402025a
  4. E. Katz and I. Willner, "Integrated nanoparticle-biomolecule hybrid systems:synthesis, properties, and applications," Angew. Chem. Int. Ed., vol. 43, pp. 6042-6108, 2004. https://doi.org/10.1002/anie.200400651
  5. J. Park, K.J. An, Y.S. Hwang, J.G. Park, H.J. Noh, J.Y. Kim, J.H. Park, N.M. Hwang, and T.G. Hyeon, "Ultra-large-scale syntheses of monodisperse nanocrystals," Nat. Mater., vol. 3, pp. 891-895, 2004. https://doi.org/10.1038/nmat1251
  6. Q. Zhao, L. Wang, R. Cheng, L. Mao, R.D. Arnold, E.W. Howerth, Z.G. Chen, and S. Platt, "Magnetic nanoparticlebased hyperthermia for head& neck cancer in mouse models," Theranostics, vol. 2, pp. 113-121, 2012. https://doi.org/10.7150/thno.3854
  7. H.S. Cho, K.H. Lee, S.C. Lee, and L.Y. Kwak, "Analysis of the complications of 6 brain-dead patients," Korean J. Anes., vol. 29, pp. 718-723, 1995. https://doi.org/10.4097/kjae.1995.29.5.718
  8. S.S. Chu, C.O. Suh, G.E. Kim, J.K. Loh, and B.S. Kim, "Development and thermal distribution of an RF capacitive heating device," Korean J. Soc. Ther. Radiol., vol. 5, pp. 49-58, 1987.
  9. L. Jian, Y. Shi, J. Liang, C. Liu, and G. Xu, "A novel targeted magnetic fluid hyperthermia system using HTS coil array for tumor treatment," IEEE Trans. Appl. Supercon., vol. 23, article no. 4400104, 2013.
  10. Deatsch, E. Alison, and A. Benjamin, "Heating efficiency in magnetic nanoparticle Hyperthermia," J. Magn. Magn. Mater., vol. 354, pp. 163-172, 2014. https://doi.org/10.1016/j.jmmm.2013.11.006
  11. L. Neel, "Theorie du trainage magnetique des ferromagnetiques en grains fins avec applications aux terres cuites," Ann. Geophys., vol. 5, pp. 99-136, 1949.
  12. W.F. Brown, "Thermal fluctuations of a single-domain particle," phys. Rev., vol. 130, pp. 1677-1686, 1963. https://doi.org/10.1103/PhysRev.130.1677
  13. R.E. Rosensweig, "Heating magnetic fluid with alternating magnetic field," J.Magn.Magn. Mater., vol. 252, pp. 370-374, 2002. https://doi.org/10.1016/S0304-8853(02)00706-0
  14. P.C. Murphy, L.L. Wald, M. Zahn, and E. Adalsteinsson, "Proposing Magnetic Nanoparticle Hyperthermia in Lowfield MRI," Concepts in Magn. Resonance, vol. 36, pp. 36-47, 2010.
  15. M. Suto, Y. Hirota, H. Mamiya, A. Fujita, R. Kasuya, K. Tohji, and B. Jeyadevan, "Heat dissipation mechanism of magnetite nanoparticles in magnetic fluid hyperthermia," J. Magn. Magn. Mater., vol. 321, pp. 1493-1496, 2009. https://doi.org/10.1016/j.jmmm.2009.02.070
  16. M.G. Weimuller, M. Zeisberger, and K.M. Krishnan, "Sizedependant heating rates of iron oxide nanoparticles for magnetic fluid hyperthermia," J. Magn. Magn. Mater., vol. 321, pp. 1947-1950, 2009. https://doi.org/10.1016/j.jmmm.2008.12.017