Imaging Science in Dentistry

Korean Academy of Oral and Maxillofacial Radiology (대한영상치의학회)
권호 표지
DOI QR코드

DOI QR Code

Basic principles and applications of $^{18}F$-FDG-PET/CT in oral and maxillofacial imaging: A pictorial essay

  • Omami, Galal (Department of Oral Diagnosis and Polyclinics, Faculty of Dentistry, The Hong Kong University) ;
  • Tamimi, Dania (BeamReaders Inc.) ;
  • Branstetter, Barton F. (Departments of Otolaryngology and Radiology, University of Pittsburgh School of Medicine)
  • Received : 2014.04.30
  • Accepted : 2014.07.04
  • Published : 2014.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

A combination of positron emission tomography (PET) with $^{18}F$-labeled fluoro-2-deoxyglucose ($^{18}F$-FDG) and computed tomography ($^{18}F$-FDG-PET/CT) has increasingly become a widely used imaging modality for the diagnosis and management of head and neck cancer. On the basis of both recent literature and our professional experience, we present a set of principles with pictorial illustrations and clinical applications of FDG-PET/CT in the evaluation and management planning of squamous cell carcinoma of the oral cavity and oropharynx. We feel that this paper will be of interest and will aid the learning of oral and maxillofacial radiology trainees and practitioners.

Keywords

References

  1. Chandra R. Nuclear medicine physics: the basics. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2004.
  2. Blodgett TM, Fukui MB, Snyderman CH, Branstetter BF 4th, McCook BM, Townsend DW, et al. Combined PET-CT in the head and neck: part 1. Physiologic, altered physiologic, and artifactual FDG uptake. Radiographics 2005; 25: 897-912. https://doi.org/10.1148/rg.254035156
  3. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. Cancer statistics, 2006. CA Cancer J Clin 2006; 56:106-30. https://doi.org/10.3322/canjclin.56.2.106
  4. Forastiere A, Koch W, Trotti A, Sidransky D. Head and neck cancer. N Engl J Med 2001; 345: 1890-900. https://doi.org/10.1056/NEJMra001375
  5. Antoch G, Vogt FM, Freudenberg LS, Nazaradeh F, Goehde SC, Barkhausen J, et al. Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology. JAMA 2003; 290: 3199-206. https://doi.org/10.1001/jama.290.24.3199
  6. Ha PK, Hdeib A, Goldenberg D, Jacene H, Patel P, Koch W, et al. The role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2006; 132: 12-6. https://doi.org/10.1001/archotol.132.1.12
  7. Suzuki H, Hasegawa Y, Terada A, Ogawa T, Hyodo I, Suzuki M, et al. Limitations of FDG-PET and FDG-PET with computed tomography for detecting synchronous cancer in pharyngeal cancer. Arch Otolaryngol Head Neck Surg 2008; 134: 1191-5. https://doi.org/10.1001/archotol.134.11.1191
  8. Branstetter BF 4th, Blodgett TM, Zimmer LA, Snyderman CH, Johnson JT, Raman S, et al. Head and neck malignancy: Is PET/CT more accurate than PET or CT alone? Radiology 2005; 235: 580-6. https://doi.org/10.1148/radiol.2352040134
  9. Yau YY, Samman N, Yeung RW. Positron emission tomography/computed tomography true fusion imaging in clinical head and neck oncology: early experience. J Oral Maxillofac Surg 2005; 63: 479-86. https://doi.org/10.1016/j.joms.2004.07.022
  10. Layland MK, Sessions DG, Lenox J. The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+. Laryngoscope 2005; 115: 629-39. https://doi.org/10.1097/01.mlg.0000161338.54515.b1
  11. McHam SA, Adelstein DJ, Rybicki LA, Lavertu P, Esclamado RM, Wood BG, et al. Who merits a neck dissection after definitive chemoradiotherapy for N2-N3 squamous cell head and neck cancer? Head Neck 2003; 25: 791-8. https://doi.org/10.1002/hed.10293
  12. Brouwer J, Senft A, de Bree R, Comans EF, Golding RP, Castelijns JA, et al. Screening for distant metastases in patients with head and neck cancer: is there a role for (18)FDG-PET? Oral Oncol 2006; 42: 275-80. https://doi.org/10.1016/j.oraloncology.2005.07.009
  13. Jones J, Farag I, Hain SF, McGurk M. Positron emission tomography (PET) in the management of oro-pharyngeal cancer. Eur J Surg Oncol 2005; 31: 170-6. https://doi.org/10.1016/j.ejso.2004.08.007
  14. Ng SH, Yen TC, Liao CT, Chang JT, Chan SC, Ko SF, et al. 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation. J Nucl Med 2005; 46: 1136-43.
  15. Krabbe CA, Dijkstra PU, Pruim J, van der Laan BF, van der Wal JE, Gravendeel JP, et al. FDG PET in oral and oropharyngeal cancer. Value for confirmation of N0 neck and detection of occult metastases. Oral Oncol 2008; 44: 31-6. https://doi.org/10.1016/j.oraloncology.2006.12.003
  16. Kim MR, Roh JL, Kim JS, Choi SH, Nam SY, Kim SY. 18Ffluorodeoxyglucose- positron emission tomography and bone scintigraphy for detecting bone metastases in patients with malignancies of the upper aerodigestive tract. Oral Oncol 2008; 44: 148-52. https://doi.org/10.1016/j.oraloncology.2007.01.011
  17. Kwee TC, Kwee RM. Combined FDG-PET/CT for the detection of unknown primary tumors: systematic review and metaanalysis. Eur Radiol 2009; 19: 731-44. https://doi.org/10.1007/s00330-008-1194-4
  18. Freudenberg LS, Fischer M, Antoch G, Jentzen W, Gutzeit A, Rosenbaum SJ, et al. Dual modality of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in patients with cervical carcinoma of unknown primary. Med Princ Pract 2005; 14: 155-60. https://doi.org/10.1159/000084632
  19. Torizuka T, Tanizaki Y, Kanno T, Futatsubashi M, Naitou K, Ueda Y, et al. Prognostic value of 18F-FDG PET in patients with head and neck squamous cell cancer. AJR Am J Roentgenol 2009; 192: W156-60. https://doi.org/10.2214/AJR.08.1429
  20. Machtay M, Natwa M, Andrel J, Hyslop T, Anne PR, Lavarino J, et al. Pretreatment FDG-PET standardized uptake value as a prognostic factor for outcome in head and neck cancer. Head Neck 2009; 31: 195-201. https://doi.org/10.1002/hed.20942
  21. Allal AS, Slosman DO, Kebdani T, Allaoua M, Lehmann W, Dulguerov P. Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-D-glucose. Int J Radiat Oncol Biol Phys 2004; 59: 1295-300. https://doi.org/10.1016/j.ijrobp.2003.12.039
  22. Yao M, Smith RB, Graham MM, Hoffman HT, Tan H, Funk GF, et al. The role of FDG PET in management of neck metastasis from head-and-neck cancer after definitive radiation treatment. Int J Radiat Oncol Biol Phys 2005; 63: 991-9. https://doi.org/10.1016/j.ijrobp.2005.03.066
  23. de Visscher AV, Manni JJ. Routine long-term follow-up in patients treated with curative intent for squamous cell carcinoma of the larynx, pharynx, and oral cavity. Does it make sense? Arch Otolaryngol Head Neck Surg 1994; 120: 934-9. https://doi.org/10.1001/archotol.1994.01880330022005
  24. Porceddu SV, Jarmolowski E, Hicks RJ, Ware R, Weih L, Rischin D, et al. Utility of positron emission tomography for the detection of disease in residual neck nodes after (chemo) radiotherapy in head and neck cancer. Head Neck 2005; 27: 175-81. https://doi.org/10.1002/hed.20130
  25. Zimmer LA, Snyderman C, Fukui MB, Blodgett T, McCook B, Townsend DW, et al. The use of combined PET/CT for localizing recurrent head and neck cancer: the Pittsburgh experience. Ear Nose Throat J 2005; 84: 108-10.
  26. Goerres GW, Schmid DT, Gratz KW, von Schulthess GK, Eyrich GK. Impact of whole body positron emission tomography on initial staging and therapy in patients with squamous cell carcinoma of the oral cavity. Oral Oncol 2003; 39: 547-51. https://doi.org/10.1016/S1368-8375(03)00016-2
  27. Ryan WR, Fee WE Jr, Le QT, Pinto HA. Positron emission tomography for surveillance of head and neck cancer. Laryngoscope 2005; 115: 645-50. https://doi.org/10.1097/01.mlg.0000161345.23128.d4
  28. Fukui MB, Blodgett TM, Snyderman CH, Johnson JJ, Myers EN, Townsend DW, et al. Combined PET-CT in the head and neck. Part 2. Diagnostic uses and pitfalls of oncologic imaging. Radiographics 2005; 25: 913-30. https://doi.org/10.1148/rg.254045136
  29. Kubota R, Yamada S, Kubota K, Ishiwata K, Tamahashi N, Ido T. Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med 1992; 33: 1972-80.
  30. Veeramachaneni R, Gulick J, Halldorsson A, Van T, Zhang P, Herrera G. Benign myoepithelioma of the lung: a case report and review of the literature. Arch Pathol Lab Med 2001; 125: 1494-6.

Cited by

  1. Diagnostic aids in detection of oral cancer: An update vol.4, pp.3, 2014, https://doi.org/10.5321/wjs.v4.i3.115