Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
권호 표지
DOI QR코드

DOI QR Code

Lactobacillus brevis G101 Inhibits the Absorption of Monosodium Glutamate in Mice

  • Jang, Se-Eun (Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University) ;
  • Han, Myung Joo (Department of Food and Nutrition, Kyung Hee University) ;
  • Kim, Se-Young (R & D Center, CTCBIO Inc.) ;
  • Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University)
  • Received : 2014.02.27
  • Accepted : 2014.07.17
  • Published : 2014.11.28
Download PDF
⟨ Previous Next ⟩

Abstract

To evaluate the effect of Lactobacillus brevis G-101 on absorption of monosodium glutamate (MSG), we orally administered MSG with or without G-101 in mice and measured the maximum concentration (Cmax) and blood concentration curve (AUC) of MSG and ${\gamma}$-aminobutyric acid (GABA). Oral administration of G-101 ($1{\times}10^9CFU/mouse$) potently inhibited Cmax and AUC of MSG by 97.8% and 94.3%, respectively (p < 0.05), but increased those of GABA by 32.1% and 67.7%, respectively (p < 0.05). G-101 inhibited the absorption of MSG. These results suggest that G-101 may reduce the side effect of MSG by inhibiting the absorption of MSG.

Keywords

References

  1. Campieri M, Gionchetti P. 1999. Probiotics in inflammatory bowel disease: new insight to pathogenesis or a possible therapeutic alternative. Gastroenterology 116: 1246-1260. https://doi.org/10.1016/S0016-5085(99)70029-6
  2. Cherubini E, Gaiarsa JL, Ben-Ari Y. 1991. GABA: an excitatory transmitter in early postnatal life. Trends Neurosci. 14: 515-519. https://doi.org/10.1016/0166-2236(91)90003-D
  3. Cho YR, Chang JY, Chang HC. 2007. Production of gammaaminobutyric acid (GABA) by Lactobacillus buchneri isolated from kimchi and its neuroprotective effect on neuronal cells. J. Microbiol. Biotechnol. 17: 104-109.
  4. Jang SE, Hyam SR, Han MJ, Kim SY, Lee BG, Kim DH. 2013. Lactobacillus brevis G-101 ameliorates colitis in mice by inhibiting NF-$\kappa$B, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages. J. Appl. Microbiol. 115: 888-896. https://doi.org/10.1111/jam.12273
  5. Jung IH, Jung MA, Kim EJ, Han MJ, Kim DH. 2012. Lactobacillus pentosus var. plantarum C29 protects scopolamineinduced memory deficit in mice. J. Appl. Microbiol. 113: 1498-1506. https://doi.org/10.1111/j.1365-2672.2012.05437.x
  6. Kanmani P, Satish Kumar R, Yuvaraj N, Paari KA, Pattukumar V, Arul V. 2013. Probiotics and its functionally valuable products - a review. Crit. Rev. Food Sci. Nutr. 53: 641-658. https://doi.org/10.1080/10408398.2011.553752
  7. Kumari A, Catanzaro R, Marotta F. 2011. Clinical importance of lactic acid bacteria: a short review. Acta Bio-med. 82: 177-180.
  8. Lee JH, Lee B, Lee HS, Bae EA, Lee H, Ahn YT, et al. 2009. Lactobacillus suntoryeus inhibits pro-inflammatory cytokine expression and TLR-4-linked NF-kappaB activation in experimental colitis. Int. J. Colorect. Dis. 24: 231-237. https://doi.org/10.1007/s00384-008-0618-6
  9. Morselli PL, Garattini S. 1970. Monosodium glutamate and the Chinese restaurant syndrome. Nature 227: 611-612. https://doi.org/10.1038/227611a0
  10. Perdigon G, de Jorrat WEB, de Petrino SF, Valerde de Budeguer M. 1991. Effect of oral administration of Lactobacillus casei on various biological functions of the host. Food Agric. Immunol. 3: 93-102. https://doi.org/10.1080/09540109109354735
  11. Schaumburg HH, Byck R, Gerstl R, Mashman JH. 1969. Monosodium L-glutamate: its pharmacology and role in the Chinese restaurant syndrome. Science 163: 826-828. https://doi.org/10.1126/science.163.3869.826
  12. Schaumburg H. 1986. Chinese-restaurant syndrome. New Engl. J. Med. 278: 1122.
  13. Scopp AL. 1991. MSG and hydrolyzed vegetable protein induced headache: review and case studies. Headache 31: 107-110. https://doi.org/10.1111/j.1526-4610.1991.hed3102107.x
  14. Shimada A, Cairns BE, Vad N, Ulriksen K, Pedersen AM, Svensson P, Baad-Hansen L. 2013. Headache and mechanical sensitization of human pericranial muscles after repeated intake of monosodium glutamate (MSG). J. Headache Pain 14: 2. https://doi.org/10.1186/1129-2377-14-2
  15. Tabuchi M, Ozaki M, Tamura A, Yamada N, Ishida T, Hosoda M, Hosono A. 2003. Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats. Biosci. Biotechnol. Biochem. 67: 1421-1424. https://doi.org/10.1271/bbb.67.1421
  16. Tamura T, Noda M, Ozaki M, Maruyama M, Matoba Y, Kumagai T, Sugiyama M. 2010. Establishment of an efficient fermentation system of gamma-aminobutyric acid by a lactic acid bacterium, Enterococcus avium G-15, isolated from carrot leaves. Biol. Pharm. Bull. 33: 1673-1679. https://doi.org/10.1248/bpb.33.1673
  17. Tung YT, Lee BH, Liu CF, Pan TM. 2011. Optimization of culture condition for ACEI and GABA production by lactic acid bacteria. J. Food Sci. 76: M585-M591. https://doi.org/10.1111/j.1750-3841.2011.02379.x
  18. Xiong JS, Branigan D, Li M. 2009. Deciphering the MSG controversy. Int. J. Clin. Exp. Med. 2: 329-336.
  19. Yang WH, Drouin MA, Herbert M, Mao Y, Karsh J. 1997. The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study. J. Allergy Clin. Immunol. 99: 757-762. https://doi.org/10.1016/S0091-6749(97)80008-5
  20. Zhang Y, S ong L, G ao Q , Yu SM, Li L, G ao N F. 2012. The two-step biotransformation of monosodium glutamate to GABA by Lactobacillus brevis growing and resting cells. Appl. Microbiol. Biotechnol. 94: 1619-1627. https://doi.org/10.1007/s00253-012-3868-8

Cited by

  1. Attenuating effect of Lactobacillus brevis G101 on the MSG symptom complex in a double-blind, placebo-controlled study vol.9, pp.6, 2014, https://doi.org/10.4162/nrp.2015.9.6.673