Journal of Magnetics

The Korean Magnetics Society (한국자기학회)
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Changes in Poly ADP Ribose Polymerase Immune Response Cells of Cerebral Ischaemia Induced Rat by Transcranial Magnetic Stimulation of Alternating Current Approach

  • Koo, Hyun-Mo (Department of Physical Therapy, College of Science, Kyung sung University) ;
  • Kim, Whi-Young (Department of Biomedical Engineering, Dongju College University)
  • Received : 2014.09.28
  • Accepted : 2014.10.13
  • Published : 2014.12.31
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Abstract

This study examined effect of a transcranial magnetic stimulation device with a commercial-frequency approach on the neuronal cell death caused ischemia. For a simple transcranial magnetic stimulation device, the experiment was conducted on an ischemia induced rat by transcranial magnetic stimulation of a commercial-frequency approach, controlling the firing angle using a Triac power device. The transcranial magnetic stimulation device was controlled at a voltage of 220 V 60 Hz and the trigger of the Triac gate was varied from $45^{\circ}$ up to $135^{\circ}$. Cerebral ischemia was caused by ligating the common carotid artery of male SD rats and reperfusion was performed again to blood after 5 minutes. Protein Expression was examined by Western blotting and the immune response cells reacting to the antibodies of Poly ADP ribose polymerase in the cerebral nerve cells. As a result, for the immune response cells of Poly ADP ribose polymerase related to necrosis, the transcranial magnetic stimulation device suppressed necrosis and had a protective effect on nerve cells. The effect was greatest within 12 hours after ischemia. Therefore, it is believed that in the case of brain damage caused by ischemia, the function of brain cells can be restored and the impairment can be improved by the application of transcranial magnetic stimulation.

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  1. Arm Cortex S3C2440 Microcontroller Application for Transcranial Magnetic Stimulation's Pulse Forming on Bax Reactive Cells and Cell Death in Ischemia Induced Rats vol.21, pp.2, 2016, https://doi.org/10.4283/JMAG.2016.21.2.266