DOI QR코드

DOI QR Code

Metastatic lipid-rich mammary carcinoma in a dog

  • Kim, Myung-Chul (Laboratory of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, So-Yeon (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Lee, Su-Hyung (Laboratory of Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Dae-Yong (Laboratory of Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Yoon, Jung-Hee (Laboratory of Radiology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Wan Hee (Laboratory of Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Jeong-Ha (Laboratory of Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Yongbaek (Laboratory of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University)
  • Received : 2014.09.26
  • Accepted : 2014.11.26
  • Published : 2014.12.31

Abstract

An adult female dog was presented for evaluation of mammary gland masses. Complete blood count and serum chemistry data were within normal limits. Fine-needle aspiration cytology of the mammary masses revealed clusters of malignant epithelial cells with clear cytoplasmic vacuoles. Based on histopathological findings, a diagnosis of lipid-rich mammary carcinoma was made. Approximately 5 weeks after surgical removal, the tumor recurred at the surgery site and metastasis to the tibia was detected. Due to the poor prognosis and deterioration of the condition, the dog was euthanized.

Keywords

References

  1. Brodey R, Goldschmidt M, Roszel J. Canine mammarygland neoplasms. AAHA 1983, 19, 61-90.
  2. Clemente M, Perez-Alenza MD, Pena L. Metastasis of canine inflammatory versus non-inflammatory mammary tumours. J Comp Pathol 2010, 143, 157-163. https://doi.org/10.1016/j.jcpa.2010.02.002
  3. Cooley DM, Waters DJ. Skeletal metastasis as the initial clinical manifestation of metastatic carcinoma in 19 dogs. J Vet Intern Med 1998, 12, 288-293. https://doi.org/10.1111/j.1939-1676.1998.tb02124.x
  4. Dobson JM, Samuel S, Milstein H, Rogers K, Wood JL. Canine neoplasia in the UK: estimates of incidence rates from a population of insured dogs. J Small Anim Pract 2002, 43, 240-246. https://doi.org/10.1111/j.1748-5827.2002.tb00066.x
  5. Espinosa de los Monteros A, Hellmen E, Ramirez GA, Herraez P, Rodriguez F, Ordas J, Millan Y, Lara A, Martin de las Mulas J. Lipid-rich carcinomas of the mammary gland in seven dogs: Clinicopathologic and immunohistochemical features. Vet Pathol 2003, 40, 718-723. https://doi.org/10.1354/vp.40-6-718
  6. Ferguson H. Canine mammary gland tumors. Vet Clin North Am Small Anim Pract 1985, 15, 501-511. https://doi.org/10.1016/S0195-5616(85)50053-4
  7. Gilbertson SR, Kurzman ID, Zachrau RE, Hurvitz AI, Black MM. Canine mammary epithelial neoplasms: biologic implications of morphologic characteristics assessed in 232 dogs. Vet Pathol 1983, 20, 127-142. https://doi.org/10.1177/030098588302000201
  8. Le TT, Huff TB, Cheng JX. Coherent anti-Stokes Raman scattering imaging of lipids in cancer metastasis. BMC Cancer 2009, 9, 42. https://doi.org/10.1186/1471-2407-9-42
  9. Magalhaes GM, Gava FN, Voorwald FA, Silveira ACT, Tinnuci-Costa M, Alessi AC. Lipid-rich carcinoma in a female dog. PUBVET 2012, 6, 1297.
  10. Misdorp W. Tumors of the mammary gland. In: Meuten DJ (ed.). Tumors in Domestic Animals. 4th ed. pp. 575-606, Iowa State University Press, Ames, 2002.
  11. Pena L, Perez-Alenza MD, Rodriguez-Bertos A, Nieto A. Canine inflammatory mammary carcinoma: histopathology, immunohistochemistry and clinical implications of 21 cases. Breast Cancer Res Treat 2003, 78, 141-148. https://doi.org/10.1023/A:1022991802116
  12. Perez-Martinez C, Garcia-Iglesias MJ, Duran-Navarrete AJ, Espinosa-Alvarez J, Garcia-Fernandez RA, Lorenzana-Robles N, Fernandez-Perez S, Garcia-Marin JF. Histopathological and immunohistochemical characteristics of two canine lipid-rich mammary carcinomas. J Vet Med A Physiol Pathol Clin Med 2005, 52, 61-66. https://doi.org/10.1111/j.1439-0442.2005.00690.x
  13. Rezaie A, Esmaeilzadeh S, Naddaf H. Lipid rich carcinoma and solid carcinoma in mammary gland of a dog: histopathologic and immunohistochemical features. Iran J Vet Sci Technol 2011, 3, 57-64.
  14. Rosen PP, Oberman HA. Tumors of the mammary gland. In: Armed Forces Institute of Pathology, Universities Associated for Research an Education in Pathology (eds.). Atlas of Tumor Pathology. 3rd Series. Pt. 7. pp. 242-243, Armed Forces Institute of Pathology, Washington, D.C., 1993.
  15. Tei M, Uchida K, Chambers JK, Harada H, Takahashi M, Nishimura R, Watanabe M, Nakayama H. Mammary lipid-rich carcinoma with extensive amyloid deposition in a dog. J Vet Med Sci 2012, 74, 809-811. https://doi.org/10.1292/jvms.11-0482