Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Cladosiphon Okamuranus Dietary Fiber on Cholesterol in High Fat Diet-Fed Rats

큰실말에서 분리된 식이섬유가 고지방식이로 유도된 흰쥐의 콜레스테롤에 미치는 영향

  • Bae, Gui-Jeong (Department of Biotechnology, College of Medical Life Science, Silla University) ;
  • Son, Jeong-Hyeon (Department of Biotechnology, College of Medical Life Science, Silla University) ;
  • Lee, Jae-Hwa (Department of Biotechnology, College of Medical Life Science, Silla University) ;
  • Jeong, Nam-Ock (MS Global Bio Co., Ltd.) ;
  • Ha, Bae-Jin (Department of Biotechnology, College of Medical Life Science, Silla University)
  • 배귀정 (신라대학교 의생명과학대학 생명공학과) ;
  • 손정현 (신라대학교 의생명과학대학 생명공학과) ;
  • 이재화 (신라대학교 의생명과학대학 생명공학과) ;
  • 정남옥 ;
  • 하배진 (신라대학교 의생명과학대학 생명공학과)
  • Received : 2014.08.21
  • Accepted : 2014.10.24
  • Published : 2014.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Cladosiphon okamuranus is edible brown algae cultured commercially and massively at Okinawa coast. Dietary fiber occupying most of C. okamuranus isn't digested and absorbed by digestive enzymes of human. But it is known to prevent and treat constipation as metabolic disease. This study was to investigate the effects of dietary fiber extracted from C. okamuranus on the damage of liver and the blood cholesterol level in the high fat diet-fed rats. The effects were measured by the levels of aspartate aminotransferase (ALT), alanine aminotransferase (AST), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) in sera. The levels of ALT, AST, TC, TG and LDL were significantly reduced in the C. okamuranus-treated group compared with the high fat diet group. But HDL level was markedly increased. The results showed that the dietary fiber extracts from C. okamuranus have the inhibitive effects of cholesterol biosynthesis in the high fat diet-fed rats.

Keywords

References

  1. Muller-Lissner, S. Classification, pharmacology, and sideeffects of common laxatives. Ital J Gastroenterol, 31, 234-237 (1999).
  2. Cha, J. T., Cho, Y. S. and Kim, D. J. Effect of chicory extract on the lipid metabolism in rats fed high fat diet. J. Korean Soc. Food Sci. Nutr., 30, 1220-1226 (2001).
  3. Krauss R. M. Triglycerides and atherogenic lipoproteins: rationale for lipid management. Am. J. Med., 105, 58S-62S (1998). https://doi.org/10.1016/S0002-9343(98)00213-7
  4. Janes P. J., Leith C. A., Pederson R. A. Meal-frequency effects on plasma hormone concentrations and cholesterol synthesis in human. Am. J. Clin. Nutr., 57, 868-874 (1993).
  5. Park, Y. H., Lee, J. S. and Lee, Y. J. Distribution of serum lipid by age and the relation of serum lipid to degree of obesity and blood pressure in Korean adults. Kor. J. Lipid., 3, 165-180 (1993).
  6. Kesaniemi, Y. A. and Miettinen, T. A. Cholesterol absorption fficiency regulates plasma cholesterol level in the innish population. Eur. J. Clin. Invest., 17, 391-395 (1987). https://doi.org/10.1111/j.1365-2362.1987.tb01132.x
  7. Kim, S. O., Rhee, I. L. and Rhee, S. J. Effectsof dietary xylooligosaccharide on hepatic UDP-glucuronyl transferase activity and compositions of fecal sterols in rat high cholesterol diets. J. Korean Soc. Food Sci. Nutr., 30, 1197-1203 (2001).
  8. Pearson, S., Stern, S. and McGaracd, T. H. A rapid accurate method for the determination of total cholesterol in serum. Anal. Chem., 25, 813-814 (1953). https://doi.org/10.1021/ac60077a041
  9. Nagaoka M., Shibata H., Kimura-Takagi I., Hashimoto S., Kimura K., Makino T., Aiyama R., Ueyama S., Yokokura T. Structural study of fucoidan from Cladosiphon okamuranus TOKIDA. Glycoconj. J, 16, 19-26 (1999). https://doi.org/10.1023/A:1006945618657
  10. Witvrouw M., De Clercq E. Sulfated polysaccharides extracted from sea algae as potential antiviral drugs. Gen. Pharmacol, 29, 497-511 (1997). https://doi.org/10.1016/S0306-3623(96)00563-0
  11. Hidari K, I., Takahashi N., Arihara M., Nagaoka M., Morita K., Suzuki T. Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga. Biochem. Biophys. Res. Commun., 376, 91-95 (2008). https://doi.org/10.1016/j.bbrc.2008.08.100
  12. Wang, W., Onnagawa, M., Yoshie, Y., & Suzuki, T. Binding of bile salts to soluble and insoluble dietary fibers of sea-weeds. F. Sci., 67.6, 1169-1173 (2001). https://doi.org/10.1046/j.1444-2906.2001.00376.x
  13. Schneemen B. O., Tietyen J. Modern nutrition in health and disease. Am. Soc. Nutrition., 60.4, 643-644 (1994).
  14. Lembo A, Camilleri M. Chronic constipation. N Engl J Med 349, 1360-1368. (2003). https://doi.org/10.1056/NEJMra020995
  15. Poller L. Fiber and diabetes. Lancet, 24, 434-435 (1970).
  16. Lee J. J., Park M. R., Kim A. R., Lee M. Y. Effects of ramie leaves on improvement of lipid metabolism and anti-obesity effect in rats fed a high fat/high cholesterol diet. Korean J Food Sci Technol, 43, 83-90 (2011). https://doi.org/10.9721/KJFST.2011.43.1.083
  17. W. T. Friedwald, R. I. Levy, D. S. Fedrreicson, "Estimation of the concentration of low density lipoprotein cholesterol in plasma,without used of the preparative ultracentrifuge", clin. Chem, 18, 499-508 (1972).
  18. Kim. H. S., You. J. H., Jo. Y. C., Lee. Y. J., Park. I. B., Park. J. W., Jung. M. A., Kim. Y. S., Kim. S. O., "Inhibitory Effects of Phellinus linteus and Rice with Phellinus linteus Mycelium on Obesity and Diabetes", Journal of the Korean society of food science and nutrition, 42.7, 1029-1035 (2013). https://doi.org/10.3746/jkfn.2013.42.7.1029
  19. Park. Y. M., Kwang. K. K., "Residual Cardiovascular Risk Remains Despite of Statin Treatment: Importance of High-Density Lipoprotein Cholesterol", Korean journal of medicine, 80.4, 397-401 (2011).
  20. Bae. C. R., Kwon. D. Y., Cha. Y. S., "Anti-Obesity Effects of Salted and Unsalted Doenjang Supplementation in C57BL/6J Mice Fed with High Fat Diet", Journal of the Korean society of food science and nutrition, .42.7, 1036-1042 (2013). https://doi.org/10.3746/jkfn.2013.42.7.1036
  21. Jung. S. G., "Effects of Caffeine intake with Power Walking on Body Composition and Triglyceride, FFA, LDL-C, Glucose, Lactic acid in Blood for Obese Female", 석사학위논문 상명대학교 대학원, pp. 1-82 (2011).
  22. Park. S. J., Jeon. Y. J., Kim. H. J., Han. J. S., "Anti-obesity Effects of Ishige okamurae Extract in C57BL/6J mice Fed High-fat Diet", Korean J. Food Sci. Technol, 45.2, 199-205 (2013). https://doi.org/10.9721/KJFST.2013.45.2.199
  23. Song. M. Y., Shambhunath Bose, Kim. H. J., "Anti-Obesity Effects of Fermented Samjung-hwan in Hign Fat Diet Rats", Journal of society of Korean medicine for obesity research, 13.1, 17-23 (2013).
  24. Heo. Y. Y., Ha. B. J., "Effect of Ligusticum chuanxiong Hort Extracts on the Bioactivity in High-fat diet-fed Obese Rats", J. Fd Hyg. Safety, 26.4, 370-376 (2011).
  25. Choi. E. O., Kim. H. S., Han. M. H., Choi. Y. H., Kim. B. W., Hwang. J. A., Hwang. H. J., "Effects of Hizikia fusiforme Extracts on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes", J Journal of life science, 22.10, 1399-1406 (2012). https://doi.org/10.5352/JLS.2012.22.10.1399
  26. Yang. S. Y., Kang. J. H., Lee. K. W., "Protective Effect of Functional Perilla frutescens Hot-water Extract Against tertbutyl hydroperoxide-Induced Liver Oxidative Damage in Rats", Journal of food hygiene and safety, 28.2, 146-151 (2013). https://doi.org/10.13103/JFHS.2013.28.2.146
  27. Ha. B. J., Nam. C. S., Park. E. K., Kang. K. S., "The Relevance of Salicornia herbacea and Epimedium koreanum to hepatotoxicity", Journal of the natural science, 15, 55-60 (2006).