Tuberculosis and Respiratory Diseases

  • 제77권5호
  • /
  • Pages.209-214
  • /
  • 2014
  • /
  • 1738-3536(pISSN)
  • /
  • 2005-6184(eISSN)
대한결핵및호흡기학회 (The Korean Academy of Tuberculosis and Respiratory Diseases)
권호 표지
DOI QR코드

DOI QR Code

The Effects of Bronchiectasis on Asthma Exacerbation

  • Kang, Hye Ran (Division of Pulmonology and Allergy, Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine) ;
  • Choi, Gyu-Sik (Division of Pulmonology and Allergy, Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine) ;
  • Park, Sun Jin (Division of Pulmonology and Allergy, Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine) ;
  • Song, Yoon Kyung (Division of Pulmonology and Allergy, Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine) ;
  • Kim, Jeong Min (Division of Pulmonology and Allergy, Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine) ;
  • Ha, Junghoon (Division of Pulmonology and Allergy, Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine) ;
  • Lee, Yung Hee (Division of Pulmonology and Allergy, Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine) ;
  • Lee, Byoung Hoon (Division of Pulmonology and Allergy, Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine) ;
  • Kim, Sang-Hoon (Division of Pulmonology and Allergy, Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine) ;
  • Lee, Jae Hyung (Division of Pulmonology and Allergy, Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine)
  • 투고 : 2014.07.01
  • 심사 : 2014.08.28
  • 발행 : 2014.11.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Bronchiectasis and asthma are different in many respects, but some patients have both conditions. Studies assessing the effect of bronchiectasis on asthma exacerbation are rare. The aim of this study is to investigate the effect of bronchiectasis on asthma exacerbation. Methods: We enrolled 2,270 asthma patients who were followed up in our hospital. Fifty patients had bronchiectasis and asthma. We selected fifty age- and sex-matched controls from the 2,220 asthma patients without bronchiectasis, and assessed asthma exacerbation and its severity based on the annual incidence of total asthma exacerbation, annual prevalence of steroid use, and frequency of emergency room visits and hospitalizations due to asthma exacerbation in each group. Results: Fifty patients (2.2%) had bronchiectasis and asthma. The annual incidence of asthma exacerbation was higher in patients with asthma and bronchiectasis than in patients with asthma alone ($1.08{\pm}1.68$ vs. $0.35{\pm}0.42$, p=0.004). The annual prevalence of steroid use ($0.9{\pm}1.54$ vs. $0.26{\pm}0.36$, p=0.006) and the frequency of emergency room visits ($0.46{\pm}0.84$ vs. $0.02{\pm}0.13$, p=0.001) due to asthma exacerbation were also higher in patients with asthma and bronchiectasis than in patients with asthma alone. Conclusion: Bronchiectasis is associated with difficult asthma control.

키워드

참고문헌

  1. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention 2013 [Internet]. Global Initiative for Asthma; [cited 2014 Apr 1]. Available from: http:// www.ginasthma.org/.
  2. Kim C, Kim DG. Bronchiectasis. Tuberc Respir Dis 2012;73: 249-57. https://doi.org/10.4046/trd.2012.73.5.249
  3. Seitz AE, Olivier KN, Steiner CA, Montes de Oca R, Holland SM, Prevots DR. Trends and burden of bronchiectasis-associated hospitalizations in the United States, 1993-2006. Chest 2010;138:944-9. https://doi.org/10.1378/chest.10-0099
  4. Oguzulgen IK, Kervan F, Ozis T, Turktas H. The impact of bronchiectasis in clinical presentation of asthma. South Med J 2007;100:468-71. https://doi.org/10.1097/SMJ.0b013e31802fa16f
  5. McGuinness G, Naidich DP, Leitman BS, McCauley DI. Bronchiectasis: CT evaluation. AJR Am J Roentgenol 1993;160:253-9. https://doi.org/10.2214/ajr.160.2.8424327
  6. Niggemann B, Reibel S, Wahn U. The atopy patch test (APT): a useful tool for the diagnosis of food allergy in children with atopic dermatitis. Allergy 2000;55:281-5. https://doi.org/10.1034/j.1398-9995.2000.00464.x
  7. Angrill J, Agusti C, De Celis R, Filella X, Rano A, Elena M, et al. Bronchial inflammation and colonization in patients with clinically stable bronchiectasis. Am J Respir Crit Care Med 2001;164:1628-32. https://doi.org/10.1164/ajrccm.164.9.2105083
  8. Scheinberg P, Shore E. A pilot study of the safety and efficacy of tobramycin solution for inhalation in patients with severe bronchiectasis. Chest 2005;127:1420-6. https://doi.org/10.1378/chest.127.4.1420
  9. Murray MP, Govan JR, Doherty CJ, Simpson AJ, Wilkinson TS, Chalmers JD, et al. A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2011;183:491-9. https://doi.org/10.1164/rccm.201005-0756OC
  10. Watson SH, Kibler CS. The role of allergy in bronchiectasis. J Allergy 1939;10:364-76. https://doi.org/10.1016/S0021-8707(39)90151-6
  11. Varpela E, Laitinen LA, Keskinen H, Korhola O. Asthma, allergy and bronchial hyper-reactivity to histamine in patients with bronchiectasis. Clin Allergy 1978;8:273-80. https://doi.org/10.1111/j.1365-2222.1978.tb03224.x
  12. Ip M, Lam WK, So SY, Liong E, Chan CY, Tse KM. Analysis of factors associated with bronchial hyperreactivity to methacholine in bronchiectasis. Lung 1991;169:43-51. https://doi.org/10.1007/BF02714140
  13. Saynajakangas O, Keistinen T, Tuuponen T, Kivela SL. Links between hospital diagnoses of bronchiectasis and asthma. Allergy 1997;52:1120-2. https://doi.org/10.1111/j.1398-9995.1997.tb00186.x
  14. Murphy MB, Reen DJ, Fitzgerald MX. Atopy, immunological changes, and respiratory function in bronchiectasis. Thorax 1984;39:179-84. https://doi.org/10.1136/thx.39.3.179
  15. Pang J, Chan HS, Sung JY. Prevalence of asthma, atopy, and bronchial hyperreactivity in bronchiectasis: a controlled study. Thorax 1989;44:948-51. https://doi.org/10.1136/thx.44.11.948
  16. Pang J, Chan HS, Sung JY. Prevalence of asthma, atopy, and bronchial hyperreactivity in bronchiectasis: a controlled study. Thorax 1989;44:948-51. https://doi.org/10.1136/thx.44.11.948
  17. Bahous J, Cartier A, Pineau L, Bernard C, Ghezzo H, Martin RR, et al. Pulmonary function tests and airway responsiveness to methacholine in chronic bronchiectasis of the adult. Bull Eur Physiopathol Respir 1984;20:375-80.
  18. Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014;43: 343-73. https://doi.org/10.1183/09031936.00202013
  19. Ip MS, So SY, Lam WK, Yam L, Liong E. High prevalence of asthma in patients with bronchiectasis in Hong Kong. Eur Respir J 1992;5:418-23.

피인용 문헌

  1. Bronchiectasthma and asthmectasis! vol.47, pp.6, 2014, https://doi.org/10.1183/13993003.00289-2016
  2. Asthma and bronchiectasis exacerbation vol.47, pp.6, 2016, https://doi.org/10.1183/13993003.01862-2015
  3. Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients vol.19, pp.None, 2018, https://doi.org/10.1186/s12931-018-0746-7
  4. Managing comorbid conditions in severe asthma vol.209, pp.2, 2014, https://doi.org/10.5694/mja18.00196
  5. Pneumonia in young adults with asthma: impact on subsequent asthma exacerbations vol.12, pp.None, 2014, https://doi.org/10.2147/jaa.s200492
  6. Asthma-COPD-Bronchiectasis combination: an unstudied triplet vol.68, pp.2, 2014, https://doi.org/10.2478/pneum-2019-0015
  7. Paediatric and adult bronchiectasis: Specific management with coexisting asthma, COPD, rheumatological disease and inflammatory bowel disease vol.24, pp.11, 2019, https://doi.org/10.1111/resp.13615
  8. Impact of Bronchiectasis on Postoperative Pulmonary Complications after Extra-Pulmonary Surgery in Patients with Airflow Limitation vol.35, pp.13, 2020, https://doi.org/10.3346/jkms.2020.35.e80
  9. Severe asthma and bronchiectasis vol.57, pp.5, 2020, https://doi.org/10.1080/02770903.2019.1579832
  10. Clinical features associated with a doctor-diagnosis of bronchiectasis in the Severe Asthma Network in Italy (SANI) registry vol.15, pp.3, 2014, https://doi.org/10.1080/17476348.2021.1840983
  11. Comorbidities and mortality risk factors for patients with bronchiectasis vol.15, pp.5, 2014, https://doi.org/10.1080/17476348.2021.1886084
  12. Trend from 2001 to 2015 in the prevalence of bronchiectasis among patients hospitalized for asthma and effect of bronchiectasis on the in-hospital mortality vol.58, pp.8, 2014, https://doi.org/10.1080/02770903.2020.1759086
  13. How does comorbid bronchiectasis affect asthmatic patients? A meta-analysis vol.58, pp.10, 2021, https://doi.org/10.1080/02770903.2020.1784194
  14. Risk factors for the development of bronchiectasis in patients with asthma vol.11, pp.1, 2014, https://doi.org/10.1038/s41598-021-02332-w