Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Preparation and Characterization of Zaltoprofen-Loaded Polyoxalate Microspheres for Control Release

방출제어를 위한 잘토프로펜이 함유된 폴리옥살레이트 미립구의 제조와 특성

  • Kim, Kyoung Hee (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University) ;
  • Lee, Cheon Jung (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University) ;
  • Jo, Sun A (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University) ;
  • Lee, Jung Hwan (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University) ;
  • Jang, Ji Eun (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University) ;
  • Lee, Dongwon (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University) ;
  • Kwon, Soon Yong (Dept. of Orthopedic Surgery, Yeouido, St. Mary's Hospital, Catholic University of Korea) ;
  • Chung, Jin Wha (Dept. of Orthopedic Surgery, Yeouido, St. Mary's Hospital, Catholic University of Korea) ;
  • Khang, Gilson (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University)
  • 김경희 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 이천중 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 조선아 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 이정환 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 장지은 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 이동원 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 권순용 (가톨릭대학교 의과대학 여의도성모병원 정형외과) ;
  • 정진화 (가톨릭대학교 의과대학 여의도성모병원 정형외과) ;
  • 강길선 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소)
  • Received : 2013.05.23
  • Accepted : 2013.07.10
  • Published : 2013.11.25
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Abstract

Zaltoprofen loaded polyoxalate (POX) microspheres were prepared by an emulsion solvent-evaporation/extraction method like oil-in-water (O/W) for sustained release of zaltoprofen. The influence of several preparation parameters such as fabrication temperature, stirring speed, intensity of the sonication, initial drug ratio, molecular weight ($M_w$) of POX, concentration of POX and concentration of emulsifier has been investigated on the zaltoprofen release profiles. Physicochemical properties and morphology of zaltoprofen loaded POX microspheres were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR). Through the analyzed results, it was demonstrated that the characteristics of the microspheres greatly affected by the prepared condition. The releases behavior of zaltoprofen was investigated for 10 days in vitro. It was confirmed that the release behavior of zaltoprofen can be controlled by the manufacturing factor of solvent-evaporation/extraction method.

서방성방출을 위해 잘토프로펜을 함유한 미립구를 oil-in-water(O/W) 에멀젼용매 증발법을 이용하여 제조하였다. 제조온도, 교반속도, 초음파분쇄기의 강도, 약물농도, POX의 분자량과 농도, 유화제 농도 등의 제조조건에 따른 잘토프로펜의 방출거동을 평가하였다. 잘토프로펜을 함유한 POX 미립구의 물리화학적 성질 및 형태를 X선 회절분석법(XRD)과 시차주사열량계(DSC), 적외선 분광분석기(FTIR), 주사현미경(SEM)을 통해 연구하였다. 이러한 연구 결과로부터 제조조건들에 따른 미립구의 특성을 확인할 수 있었다. 또한 POX 미립구의 분해성을 10일 동안 in vitro 실험을 통해 조사하였다. 본 연구를 통해 잘토프로펜을 함유한 POX 미립구를 최적화된 용매증발방법으로 제조하였고, 이 미립구로부터 약물의 방출제어를 확인할 수 있었다.

Keywords

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