DOI QR코드

DOI QR Code

Maxillary Sinusitis Caused by Mucormycosis

  • Ha, Yong-Yun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Lee, Suk Keun (Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University) ;
  • Park, Young-Wook (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Kim, Seong-Gon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Kim, Min Keun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Kim, Hyun-Young (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University)
  • 투고 : 2013.05.13
  • 심사 : 2013.11.26
  • 발행 : 2013.11.30

초록

A 60-year-old male complained of headache, nasal discharge, and diplopia for over one month with a history of left upper molar extraction, and he had recently experienced severe discharge of purulent exudate from his left antrum. Under the diagnosis of maxillary sinusitis, the Caldwell-Luc operation was performed, and several fragments of amorphous white mucoroid materials were removed. In the histological observation, sinus mucosa was relatively well preserved, but showed diffuse infiltration with eosinophilic polymorphonuclears. Huge molds of mucormycosis were associated with the surface of mucosa. He was treated with amphotericin-B deoxycholate, resulting in the uneventful healing of the antral lesion. The current case of antral mucormycosis was very rare but effectively treated by surgical removal of antral mucosa and the following antibiotic therapy for the strong inhabitants of fungal molds. We also presumed that the patient was superinfected with commensal fungus of mucormycosis during broad spectrum antibiotic therapy for the previous dental infection.

키워드

참고문헌

  1. Lee C, Damm DD, Neville BW, Allen C, Bouquot J. Oral and maxillofacial pathology. 3rd ed. St. Louis: Saunders; 2009. p.213-39.
  2. Barnes L. Surgical pathology of the head and neck. 3rd ed. New York: Informa Healthcare; 2009. p.1634-7.
  3. Guarner J, Brandt ME. Histopathologic diagnosis of fungal infections in the 21st century. Clin Microbiol Rev 2011;24: 247-80. https://doi.org/10.1128/CMR.00053-10
  4. Blitzer A, Lawson W, Meyers BR, Biller HF. Patient survival factors in paranasal sinus mucormycosis. Laryngoscope 1980; 90:635-48.
  5. Petrikkos G, Skiada A, Lortholary O, Roilides E, Walsh TJ, Kontoyiannis DP. Epidemiology and clinical manifestations of mucormycosis. Clin Infect Dis 2012;54 Suppl 1:S23-34. https://doi.org/10.1093/cid/cir866
  6. Ferguson BJ. Mucormycosis of the nose and paranasal sinuses. Otolaryngol Clin North Am 2000;33:349-65. https://doi.org/10.1016/S0030-6665(00)80010-9
  7. McNulty JS. Rhinocerebral mucormycosis: predisposing factors. Laryngoscope 1982;92:1140-3.
  8. Radowsky JS, Strawn AA, Sherwood J, Braden A, Liston W. Invasive mucormycosis and aspergillosis in a healthy 22-year-old battle casualty: case report. Surg Infect (Larchmt) 2011;12:397-400. https://doi.org/10.1089/sur.2010.065
  9. Mignogna MD, Fortuna G, Leuci S, et al. Mucormycosis in immunocompetent patients: a case-series of patients with maxillary sinus involvement and a critical review of the literature. Int J Infect Dis 2011;15:e533-40. https://doi.org/10.1016/j.ijid.2011.02.005
  10. Marple BF. Allergic fungal rhinosinusitis: current theories and management strategies. Laryngoscope 2001;111:1006-19. https://doi.org/10.1097/00005537-200106000-00015
  11. Kim YG, Kim JD, Ryu DM, Lee BS, Oh JH. Mucormycosis in maxilla: a case report. J Korean Assoc Oral Maxillofac Surg 2004;30:69-73.
  12. Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 2005;41:634-53. https://doi.org/10.1086/432579
  13. Miloro M, Ghali GE, Larsen PE, Waite PD, editors. Peterson's principles of oral and maxillofacial surgery. 2nd ed. Hamilton, Ont.; London: B.C Decker Inc; 2004. p.295-312.
  14. Seelig MS. Mechanisms by which antibiotics increase the incidence and severity of candidiasis and alter the immunological defenses. Bacteriol Rev 1966;30:442-59.
  15. Savage DC. Microbial interference between indigenous yeast and lactobacilli in the rodent stomach. J Bacteriol 1969;98: 1278-83.
  16. Kinsman OS, Pitblado K. Candida albicans gastrointestinal colonization and invasion in the mouse: effect of antibacterial dosing, antifungal therapy and immunosuppression. Mycoses 1989;32:664-74.
  17. Brook I. Aerobic and anaerobic bacterial flora of normal maxillary sinuses. Laryngoscope 1981;91:372-6.
  18. Kerr JR. Bacterial inhibition of fungal growth and pathogenicity. Microb Ecol Health Dis 1999;11:129-42. https://doi.org/10.1080/089106099435709