Journal of Korean Neurosurgical Society

  • 제54권4호
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  • Pages.309-316
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  • 2013
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
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Clinical Analysis of Intracranial Hemangiopericytoma

  • Park, Byoung-Joo (Department of Neurosurgery, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital) ;
  • Kim, Young-Il (Department of Neurosurgery, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital) ;
  • Hong, Yong-Kil (Department of Neurosurgery, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital) ;
  • Jeun, Sin-Soo (Department of Neurosurgery, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital) ;
  • Lee, Kwan-Sung (Department of Neurosurgery, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital) ;
  • Lee, Youn-Soo (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital)
  • 투고 : 2013.07.27
  • 심사 : 2013.10.10
  • 발행 : 2013.10.28
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초록

Objective : Intracranial hemangiopericytomas (HPCs) are rare tumors with aggressive behavior, including local recurrence and distant metastasis. We conducted this retrospective study to evaluate the efficacy of grossly total resection and adjuvant radiotherapy (RT) for these tumors. Methods : A total of 13 patients treated for intracranial HPC from January 1995 through May 2013 were included in this retrospective study. We analyzed the clinical presentations, radiologic appearances, treatment results, and follow-up outcomes, as well as reviewed other studies. Results : The ages of the patients at the time of diagnosis ranged from 26 to 73 years (mean : 48 years). The majority of the patients were male (92.3%), and the majority of the tumors were located in the parasagittal and falx. The ratio of intracranial HPCs to meningiomas was 13 : 598 in same period, or 2.2%. Seven patients (53.8%) had anaplastic HPCs. Nine patients (69.2%) underwent gross total tumor resection in the first operation without mortality. Eleven patients (84.6%) underwent postoperative adjuvant RT. Follow-up period ranged from 13 to 185 months (mean : 54.3 months). The local recurrence rate was 46.2% (6/13), and there were no distant metastases. The 10-year survival rate after initial surgery was 83.9%. The initial mean Karnofsky performance scale (KPS) was 70.8 and the final mean KPS was 64.6. Conclusion : Gross total tumor resection upon initial surgery is very important. We believe that adjuvant RT is helpful even with maximal tumor resection. Molecular biologic analyses and chemotherapy studies are required to achieve better outcomes in recurrent intracranial HPCs.

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참고문헌

  1. Alen JF, Lobato RD, Gomez PA, Boto GR, Lagares A, Ramos A, et al. : Intracranial hemangiopericytoma : study of 12 cases. Acta Neurochir (Wien) 143 : 575-586, 2001 https://doi.org/10.1007/s007010170062
  2. Bassiouni H, Asgari S, Hübschen U, König HJ, Stolke D : Intracranial hemangiopericytoma : treatment outcomes in a consecutive series. Zentralbl Neurochir 68 : 111-118, 2007 https://doi.org/10.1055/s-2007-981674
  3. Beadle GF, Hillcoat BL : Treatment of advanced malignant hemangiopericytoma with combination adriamycin and DTIC : a report of four cases. J Surg Oncol 22 : 167-170, 1983 https://doi.org/10.1002/jso.2930220306
  4. Begg CF, Garret R : Hemangiopericytoma occurring in the meninges : case report. Cancer 7 : 602-606, 1954 https://doi.org/10.1002/1097-0142(195405)7:3<602::AID-CNCR2820070319>3.0.CO;2-A
  5. Brunori A, Delitala A, Oddi G, Chiappetta F : Recent experience in the management of meningeal hemangiopericytomas. Tumori 83 : 856-861, 1997
  6. Bydder GM, Kingsley DP, Brown J, Niendorf HP, Young IR : MR imaging of meningiomas including studies with and without gadolinium-DTPA. J Comput Assist Tomogr 9 : 690-697, 1985 https://doi.org/10.1097/00004728-198507010-00006
  7. Chamberlain MC, Glantz MJ : Sequential salvage chemotherapy for recurrent intracranial hemangiopericytoma. Neurosurgery 63 : 720-726; author reply 726-727, 2008 https://doi.org/10.1227/01.NEU.0000325494.69836.51
  8. Chawalparit O, Artkaew C, Anekthananon T, Tisavipat N, Charnchaowanish P, Sangruchi T : Diagnostic accuracy of perfusion CT in differentiating brain abscess from necrotic tumor. J Med Assoc Thai 92 : 537-542, 2009
  9. Chiechi MV, Smirniotopoulos JG, Mena H : Intracranial hemangiopericytomas : MR and CT features. AJNR Am J Neuroradiol 17 : 1365-1371, 1996
  10. Combs SE, Thilmann C, Debus J, Schulz-Ertner D : Precision radiotherapy for hemangiopericytomas of the central nervous system. Cancer 104 : 2457-2465, 2005 https://doi.org/10.1002/cncr.21448
  11. Cosentino CM, Poulton TB, Esguerra JV, Sands SF : Giant cranial hemangiopericytoma : MR and angiographic findings. AJNR Am J Neuroradiol 14 : 253-256, 1993
  12. Di Nallo AM, Vidiri A, Marzi S, Mirri A, Fabi A, Carapella CM, et al. : Quantitative analysis of CT-perfusion parameters in the evaluation of brain gliomas and metastases. J Exp Clin Cancer Res 28 : 38, 2009 https://doi.org/10.1186/1756-9966-28-38
  13. Ding B, Ling HW, Chen KM, Jiang H, Zhu YB : Comparison of cerebral blood volume and permeability in preoperative grading of intracranial glioma using CT perfusion imaging. Neuroradiology 48 : 773-781, 2006 https://doi.org/10.1007/s00234-006-0120-1
  14. Du G, Zhou L, Li S, Mao Y, Chen H : Management of hemangiopericytomas in the central nervous system. Chin Med J (Engl) 114 : 795-798, 2001
  15. Dufour H, Métellus P, Fuentes S, Murracciole X, Régis J, Figarella-Branger D, et al. : Meningeal hemangiopericytoma : a retrospective study of 21 patients with special review of postoperative external radiotherapy. Neurosurgery 48 : 756-762; discussion 762-763, 2001
  16. Ecker RD, Marsh WR, Pollock BE, Kurtkaya-Yapicier O, McClelland R, Scheithauer BW, et al. : Hemangiopericytoma in the central nervous system : treatment, pathological features, and long-term follow up in 38 patients. J Neurosurg 98 : 1182-1187, 2003 https://doi.org/10.3171/jns.2003.98.6.1182
  17. Feldman ZT, Reichenthal E, Zucker G, Greiff M : Haemangiopericytoma presenting with intracerebral haemorrhage. Case report and review of literature. Acta Neurochir (Wien) 112 : 151-153, 1991 https://doi.org/10.1007/BF01405145
  18. Fountas KN, Kapsalaki E, Kassam M, Feltes CH, Dimopoulos VG, Robinson JS, et al. : Management of intracranial meningeal hemangiopericytomas : outcome and experience. Neurosurg Rev 29 : 145-153, 2006 https://doi.org/10.1007/s10143-005-0001-9
  19. Fredriksson F, Nordborg C, Hallén T, Blomquist E : Haemangiopericytoma presenting with acute intracerebral haemorrhage--a case report and literature review. Acta Oncol 52 : 753-758, 2013 https://doi.org/10.3109/0284186X.2012.716163
  20. Galanis E, Buckner JC, Scheithauer BW, Kimmel DW, Schomberg PJ, Piepgras DG : Management of recurrent meningeal hemangiopericytoma. Cancer 82 : 1915-1920, 1998 https://doi.org/10.1002/(SICI)1097-0142(19980515)82:10<1915::AID-CNCR15>3.0.CO;2-W
  21. Ghia AJ, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD : Intracranial hemangiopericytoma and the role of radiation therapy : a population based analysis. Neurosurgery 72 : 203-209, 2013 https://doi.org/10.1227/NEU.0b013e31827b9e68
  22. Goellner JR, Laws ER Jr, Soule EH, Okazaki H : Hemangiopericytoma of the meninges. Mayo Clinic experience. Am J Clin Pathol 70 : 375-380, 1978 https://doi.org/10.1093/ajcp/70.3.375
  23. Guthrie BL, Ebersold MJ, Scheithauer BW, Shaw EG : Meningeal hemangiopericytoma : histopathological features, treatment, and long-term follow-up of 44 cases. Neurosurgery 25 : 514-522, 1989 https://doi.org/10.1227/00006123-198910000-00003
  24. Horten BC, Urich H, Rubinstein LJ, Montague SR : The angioblastic meningioma : a reappraisal of the nosological problem. Light-, electron-microscopic, tissue, and organ culture observations. J Neurol Sci 31 : 387-410, 1977 https://doi.org/10.1016/0022-510X(77)90217-9
  25. Jääskeläinen J, Servo A, Haltia M, Wahlström T, Valtonen S : Intracranial hemangiopericytoma : radiology, surgery, radiotherapy, and outcome in 21 patients. Surg Neurol 23 : 227-236, 1985 https://doi.org/10.1016/0090-3019(85)90087-4
  26. Jain R, Scarpace L, Ellika S, Schultz LR, Rock JP, Rosenblum ML, et al. : First-pass perfusion computed tomography : initial experience in differentiating recurrent brain tumors from radiation effects and radiation necrosis. Neurosurgery 61 : 778-786; discussion 786-787, 2007 https://doi.org/10.1227/01.NEU.0000298906.48388.26
  27. Katsumata A, Kusaka N, Sugiu K, Nakashima H, Date I, Ohmoto T : [Use of the GDC for embolization of a tumor fed by a cavernous branch of the internal carotid artery]. No Shinkei Geka 29 : 565-569, 2001
  28. Kim JH, Jung HW, Kim YS, Kim CJ, Hwang SK, Paek SH, et al. : Meningeal hemangiopericytomas : long-term outcome and biological behavior. Surg Neurol 59 : 47-53; discussion 53-54, 2003 https://doi.org/10.1016/S0090-3019(02)00917-5
  29. Kochanek S, Schröder R, Firsching R : Hemangiopericytoma of meninges. I. Histopathological variability and differential diagnosis. Zentralbl Neurochir 47 : 183-190, 1986
  30. Liu G, Chen ZY, Ma L, Lou X, Li SJ, Wang YL : Intracranial hemangiopericytoma : MR imaging findings and diagnostic usefulness of minimum ADC values. J Magn Reson Imaging, 2013 [Epub ahead of print]
  31. Matsushige T, Nakaoka M, Yahara K, Shinagawa K, Ohnuma H, Shibukawa M, et al. : Single-stage operation for a giant haemangiopericytoma following intracranial feeder embolization. J Clin Neurosci 14 : 162-167, 2007 https://doi.org/10.1016/j.jocn.2005.09.019
  32. Mena H, Ribas JL, Pezeshkpour GH, Cowan DN, Parisi JE : Hemangiopericytoma of the central nervous system : a review of 94 cases. Hum Pathol 22 : 84-91, 1991 https://doi.org/10.1016/0046-8177(91)90067-Y
  33. Osborne DR, Dubois P, Drayer B, Sage M, Burger P, Heinz ER : Primary intracranial meningeal and spinal hemangiopericytoma : radiologic manifestations. AJNR Am J Neuroradiol 2 : 69-74, 1981
  34. Ren G, Chen S, Wang Y, Zhu RJ, Geng DY, Feng XY : Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging. Chin Med J (Engl) 123 : 2038-2044, 2010
  35. Rutkowski MJ, Jian BJ, Bloch O, Chen C, Sughrue ME, Tihan T, et al. : Intracranial hemangiopericytoma : clinical experience and treatment considerations in a modern series of 40 adult patients. Cancer 118 : 1628-1636, 2012 https://doi.org/10.1002/cncr.26411
  36. Rutkowski MJ, Sughrue ME, Kane AJ, Aranda D, Mills SA, Barani IJ, et al. : Predictors of mortality following treatment of intracranial hemangiopericytoma. J Neurosurg 113 : 333-339, 2010 https://doi.org/10.3171/2010.3.JNS091882
  37. Schiariti M, Goetz P, El-Maghraby H, Tailor J, Kitchen N : Hemangiopericytoma : long-term outcome revisited. Clinical article. J Neurosurg 114 : 747-755, 2011 https://doi.org/10.3171/2010.6.JNS091660
  38. Schröder R, Firsching R, Kochanek S : Hemangiopericytoma of meninges. II. General and clinical data. Zentralbl Neurochir 47 : 191-199, 1986
  39. Sell JJ, Hart BL, Rael JR : Hemangiopericytoma : a rare pineal mass. Neuroradiology 38 : 782-784, 1996 https://doi.org/10.1007/s002340050347
  40. Sheehan J, Kondziolka D, Flickinger J, Lunsford LD : Radiosurgery for treatment of recurrent intracranial hemangiopericytomas. Neurosurgery 51 : 905-910; discussion 910-911, 2002
  41. Shetty PM, Moiyadi AV, Sridhar E : Primary CNS hemangiopericytoma presenting as an intraparenchymal mass--case report and review of literature. Clin Neurol Neurosurg 112 : 261-264, 2010 https://doi.org/10.1016/j.clineuro.2009.12.001
  42. Soyuer S, Chang EL, Selek U, McCutcheon IE, Maor MH : Intracranial meningeal hemangiopericytoma : the role of radiotherapy : report of 29 cases and review of the literature. Cancer 100 : 1491-1497, 2004 https://doi.org/10.1002/cncr.20109
  43. Staples JJ, Robinson RA, Wen BC, Hussey DH : Hemangiopericytoma--the role of radiotherapy. Int J Radiat Oncol Biol Phys 19 : 445-451, 1990 https://doi.org/10.1016/0360-3016(90)90556-Y
  44. Stessin AM, Sison C, Nieto J, Raifu M, Li B : The role of postoperative radiation therapy in the treatment of meningeal hemangiopericytoma-experience from the SEER database. Int J Radiat Oncol Biol Phys 85 : 784-790, 2013 https://doi.org/10.1016/j.ijrobp.2012.05.042
  45. Stout AP, Murray MR : Hemangiopericytoma : a vascular tumor featuring zimmermann's pericytes. Ann Surg 116 : 26-33, 1942 https://doi.org/10.1097/00000658-194207000-00004
  46. Sundaram C, Uppin SG, Uppin MS, Rekha JS, Panigrahi MK, Purohit AK, et al. : A clinicopathological and immunohistochemical study of central nervous system hemangiopericytomas. J Clin Neurosci 17 : 469-472, 2010 https://doi.org/10.1016/j.jocn.2009.08.018
  47. Vuorinen V, Sallinen P, Haapasalo H, Visakorpi T, Kallio M, Jääskeläinen J : Outcome of 31 intracranial haemangiopericytomas : poor predictive value of cell proliferation indices. Acta Neurochir (Wien) 138 : 1399-1408, 1996 https://doi.org/10.1007/BF01411118
  48. Younis GA, Sawaya R, DeMonte F, Hess KR, Albrecht S, Bruner JM : Aggressive meningeal tumors : review of a series. J Neurosurg 82 : 17-27, 1995 https://doi.org/10.3171/jns.1995.82.1.0017

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