Progress in Medical Physics (한국의학물리학회지:의학물리)

Korean Society of Medical Physics (한국의학물리학회)
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Enhancement of the Early/Precise Diagnosis Based on the Measurement of SUVs in F-18 FDG PET/CT Whole-body Image

F-18 FDG PET/CT 전신 영상에서 SUVs 측정에 기반한 조기/정밀 진단 연구

  • Park, Jeong-Kyu (Department of Radiologic Technology, Daegu Health College) ;
  • Kim, Sung Kyu (Department of Radiation Oncology, Yeungnam University College of Medicine) ;
  • Cho, Ihn-Ho (Department of Nuclear Medicine, Yeungnam University College of Medicine) ;
  • Kong, Eun-Jung (Department of Nuclear Medicine, Yeungnam University College of Medicine) ;
  • Park, Myeong-Hwan (Department of Radiologic Technology, Daegu Health College) ;
  • Cho, Bok-Yeon (Department of Radiology, Soonchunhyang University of Hospital Gumi)
  • 박정규 (대구보건대학교 방사선과) ;
  • 김성규 (영남대학교 의과대학 방사선종양학교실) ;
  • 조인호 (영남대학교 의과대학 핵의학교실) ;
  • 공은정 (영남대학교 의과대학 핵의학교실) ;
  • 박명환 (대구보건대학교 방사선과) ;
  • 조복연 (순천향대학교 구미병원 영상의학과)
  • Received : 2013.08.12
  • Accepted : 2013.09.04
  • Published : 2013.09.30
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Abstract

Through this research, we measure the data for several SUVs such as SUVLBM, SUVBW, and SUVBSA using volume of interest in order to enhance the diagnostic level in whole-body image for healthy examinees via F-18 FDG PET/CT. Maximum value, mean value, standard deviation, and threshold value for each SUVs are shown. The measurement of SUVs are carried out with 31 examinees who have taken whole-body examination with F-18 FDG PET/CT from July, 2012 to August, 2012. To secure the preciseness of measurement, we selected 26 healthy examinees as a subject of measurement according to diagnostic view of a nuclear-medical doctor. We see from the measurement of SUVs of PET/CT that the value of SUVBW is hightest and followed by SUVLBM and SUVBSA in turn regardless of the use of contrast media. By comparing the SUVLBM-maximum data for the group used contrast media with those for the group used no contrast media, there found a trend that the measured values increase when the contrast media are used. Among them, liver, aorta, lumbar-5, and Cerebellum exhibit significant difference (p<0.05). We conclude that our data for SUVs would be basic references in overall image interpretation, and hope that the research using VOI would be active.

본 연구의 목적은 건강한 검진자들을 대상으로 F-18 FDG PET/CT 전신 영상에서 진단 수준을 향상하고자 관심부피를 이용하여 정상부위의 SUVs, 즉 SUVLBM, SUVBW, SUVBSA의 데이터를 마련하였다. 각각의 최대치(maximum), 평균치(mean), 표준편차(standard deviation), 역치(threshold)를 제시 하고자 한다. 2012년 7월부터 8월까지 전신 F-18 FDG PET/CT 검사를 시행한 총 31명을 대상으로 SUVs를 측정 하였다. 측정의 정확도를 높이고자 핵의학 전문의의 소견으로 이중에서 26명의 건강한 수검자를 대상으로 하였다. 조영제 사용유무와 관계없이 PET/CT의 SUVs 측정에서 SUVBW의 측정치가 가장 높았으며, SUVLBM, SUVBSA 순으로 나타났다. SUVLBM-최대치를 이용하여 조영제를 사용하지 않은 군과 사용한 군을 비교했을 경우, 조영제를 사용했을 경우 측정치가 증가하는 경향을 보였으며, 8부위 중 간, 대동맥, 요추-5, 소뇌는 매우 유의하게 차이가 있는 것으로 나타났다(p<0.05). PET/CT의 모든 영상의 판독에서 본 SUVs 데이터가 조기정밀/진단 수준을 향상 하는데 기초 자료가 될 것이라고 판단되며, VOI를 이용한 연구가 활발히 이루어지길 기대한다.

Keywords

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