Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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Review of Current Facial Allotransplantation and Future Aspects

안면동종이식의 현황고찰과 전망

  • Seo, Mi Hyun (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Lee, Jung A (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Oh, Jin Sil (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Kim, Soung Min (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Myoung, Hoon (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Lee, Jong Ho (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University)
  • 서미현 (서울대학교 치의학대학원 구강악안면외과학교실, 치학연구소) ;
  • 이정아 (서울대학교 치의학대학원 구강악안면외과학교실, 치학연구소) ;
  • 오진실 (서울대학교 치의학대학원 구강악안면외과학교실, 치학연구소) ;
  • 김성민 (서울대학교 치의학대학원 구강악안면외과학교실, 치학연구소) ;
  • 명훈 (서울대학교 치의학대학원 구강악안면외과학교실, 치학연구소) ;
  • 이종호 (서울대학교 치의학대학원 구강악안면외과학교실, 치학연구소)
  • Received : 2013.02.28
  • Accepted : 2013.09.21
  • Published : 2013.09.30
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Abstract

Advances in immunosuppressive treatments and microsurgical techniques have rendered composite tissues allotransplantation (CTA), such as heteregeneous or non-organ tissues, possible in humans. CTA has evolved dramatically since the first successful rat hind limb allotransplantation. Numerous clinical applications including face, hand, trachea, larynx, and vascularized joint have been performed. Although composite tissue allografts are still in their infancy, they have opened a new era in the field of transplantation surgery and pathology, so that maxillofacial reconstructive surgeons may occasionally be faced with the challenge of diagnosing skin refection of a composite tissue allograft. Facial allotransplantation (FAT) is a new surgical technique that could be considered as a new paradigm in facial reconstruction. Since the first human FAT had been achieved in 2005, 17 cases have been reported in the world up to date. However, many problems such as life-long immunosuppression, immune rejection, ethical problems and psychological problems are remained, so facial CTA is new reconstructive option with no general acceptance. The authors reviewed the indications, the results of 17 cases and their complications, and additional consideration factors in this article, and intended to raise the awareness of oral and maxillofacial surgeons in this type of facial transplantation.

Keywords

References

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