Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Ligustrum lucidum Fruits Extract Inhibits Acute Pulmonary Inflammation in Mice

생쥐에서 급성 폐렴에 대한 여정자 열매 추출물의 억제효과

  • Kwak, Ho Geun (Department of Industrial Plant Science & Technology, Chungbuk National University) ;
  • Lim, Heung-Bin (Department of Industrial Plant Science & Technology, Chungbuk National University)
  • 곽호근 (충북대학교 특용식물학과) ;
  • 임흥빈 (충북대학교 특용식물학과)
  • Received : 2013.07.12
  • Accepted : 2013.08.16
  • Published : 2013.10.30
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Abstract

Traditionally, Ligustrum lucidum fruits (LL) is one of the well-known oriental herb used in the treatment of skin and lung inflammation. This study investigated anti-inflammatory effects of LL in the pathogenesis of acute pulmonary inflammation in mice. Acute pulmonary inflammation was induced by intratracheal instillation of cigarette smoke condensate (CSC) and lipopolysaccharide (LPS) 5 times within 12 days in mice. LL extract was administered orally at a dose of 50 or 200 mg/kg. Administration of LPS and CSC significantly elevated airway hyperresponsiveness (AHR) to mice, and increased in the levels of inflammatory cells and mediators in mice. However, the LL extract significantly reduced the elevated AHR, and the increase of neutrophils, $CD4^+/CD3^+$ cells and $CD8^+/CD3^+$ cells, along with reducing the expression of TNF-${\alpha}$, IL-6, and MIP-2. Moreover, the LL extract alleviated the infiltration of inflammatory cells in expanded airway walls histologically. These results indicate that the LL extract has an inhibitory effects on acute pulmonary inflammation and AHR in murine model, and plays a crucial role as a immunomodulator which possess anti-inflammatory property.

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References

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