대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제34권3호
  • /
  • Pages.111-116
  • /
  • 2013
  • /
  • 1229-0807(pISSN)
  • /
  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지
DOI QR코드

DOI QR Code

약물-용출 생분해성 고분자 스텐트를 위한 EGCG와 디자인 파라미터의 영향에 대한 연구

A Study on Effects of EGCG and Design Parameter for Drug-Eluting Biodegradable Polymer Stents

  • 정태곤 (부산대학교 나노메디컬공학과, BK21 나노융합기술학과) ;
  • 이종호 (부산대학교 나노메디컬공학과, BK21 나노융합기술학과) ;
  • 이준재 (부산대학교 나노메디컬공학과, BK21 나노융합기술학과) ;
  • 현승휴 (일본 교토공예섬유대학교, 섬유 및 직물 과학 센터) ;
  • 한동욱 (부산대학교 나노메디컬공학과, BK21 나노융합기술학과)
  • Jung, T.G. (Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience & Nanotechnology, Pusan National University) ;
  • Lee, J.H. (Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience & Nanotechnology, Pusan National University) ;
  • Lee, J.J. (Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience & Nanotechnology, Pusan National University) ;
  • Hyon, S.H. (Center for Fiber and Textile Science, Kyoto Institute of Technology) ;
  • Han, D.W. (Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience & Nanotechnology, Pusan National University)
  • 투고 : 2013.04.03
  • 심사 : 2013.07.02
  • 발행 : 2013.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Finite element analysis(FEA) has been extensively applied in the analyses of biomechanical properties of stents. Geometrically, a closed-cell stent is an assembly of a number of repeated unit cells and exhibits periodicity in both longitudinal and circumferential directions. This study concentrates on various parameters of the FEA models for the analysis of drug-eluting biodegradable polymeric stents for application to the treatment of coronary artery disease. In order to determine the mechanical characteristics of biodegradable polymeric stents, FEA was used to model two different types of stents: tubular stents(TS) and helicoidal stents(HS). For this modeling, epigallocatechin-3-O-gallate (EGCG)-eluting poly[(L-lactide-co-${\varepsilon}$-caprolactone), PLCL] (E-PLCL) was chosen as drug-eluting stent materials. E-PLCL was prepared by blending PLCL with 5% EGCG as previously described. In addition, the effects of EGCG blending on the mechanical properties of PLCL were investigated for both types of stent models. EGCG did not affect tensile strength at break, but significantly increased elastic modulus of PLCL. It is suggested that FEA is a cost-effective method to improve the design of drug-eluting biodegradable polymeric stents.

키워드

참고문헌

  1. D.S. Baim., et al., "Management of restenosis within the Palmaz-Schatz coronary stent(the U.S. multicenter experience. The U.S. Palmaz-Schatz Stent Investigators," Am J Cardiol., vol. 71, no. 4, pp. 364-366, 1993. https://doi.org/10.1016/0002-9149(93)90813-R
  2. A. Alcocer., et al., "Clinical variables related with in-stent restenosis late regression after bare metal coronary stenting," Arch Cardiol Mex., vol. 76, no. 4, pp. 390-396, 2006.
  3. C. Lally, F. Dolan, and P.J. Prendergast, "Cardiovascular stent design and vessel stresses: a finite element analysis," J Biomech., vol. 38, no. 8, pp. 1574-1581, 2005. https://doi.org/10.1016/j.jbiomech.2004.07.022
  4. D.S. Baim, and J.P. Carrozza, Jr., "Stent thrombosis. Closing in on the best preventive treatment. Circulation," vol. 95, no. 5, pp. 1098-1100, 1997. https://doi.org/10.1161/01.CIR.95.5.1098
  5. H.C. Lee, C.S. Kim, B.C. Pak, and B.J. Baek, "Hydrodynamic Characteristics of Self-expandable Graft Stents in Steady Flow," J. Biomed. Eng. Res., vol. 24, no. 1, pp. 37-44, 2003.
  6. Devsesh Kothwala, Ankur Raval, Annimesh Choubey, "Pachlitaxel Drug Delivery From Cardiovascular Stent," Trends Biomater. Artif. Organs, vol. 19, no. 2, pp. 88-92, 2006.
  7. G.S. Frank, R.F. John, "Drug Eluting Coronary Stent : In Vitro Evaluation of Magnet Resonance Satery at 3 Tesla," Journal of Cardiovascular Magnetic Resonance, vol. 7, no. 2, pp. 415-419, 2005. https://doi.org/10.1081/JCMR-200053588
  8. Etave, F., et al., "Mechanical properties of coronary stents determined by using finite element analysis," J Biomech., vol. 34, no. 8, pp. 1065-1075, 2001. https://doi.org/10.1016/S0021-9290(01)00026-4
  9. H.H. Cho, D.W. Han. K. Matsumura, S. Tsutsumi, and S.H. Hyon, "The behavior of vascular smooth muscle cells and platelets onto epigallocatechin gallate-releasing poly(l-lactide-co-e-caprolactone) as stent-coating materials," Biomaterials, vol. 29, no. 7, pp. 884-893, 2008. https://doi.org/10.1016/j.biomaterials.2007.10.052
  10. D.W. Han, et al., "Development of epigallocatechin gallateeluting polymeric stent and its physicochemicall, biomechanical and biological evaluations," Biomed Mater, vol. 4, no. 4, pp. 044104, 2009. https://doi.org/10.1088/1748-6041/4/4/044104
  11. D.W. Han, et al., "Underlying mechanism for suppression of vascular smooth muscle cells by green tea polyphenol EGCG released from biodegradable polymers for stent application," J Biomed Mater Res A, vol. 95, no. 2, pp. 424-433, 2010.
  12. D.W. Han, M.H. Lee, B.J. Kwon, H.L. Kim, S.H. Hyon, and J.C. Park., "Selective inhibitory effect of epigallocatechin-3-gallate on migration of vascular smooth muscle cells," Molecules. Nov. 19, vol. 15, no. 11, pp. 8488-8500, 2010. https://doi.org/10.3390/molecules15118488
  13. D. Martin, and F.J. Boyle, "Computational structural modelling of coronary stent deployment: a review," Comput Methods Biomech Biomed Engin., vol. 14, no. 4, pp. 331-48, 2011. https://doi.org/10.1080/10255841003766845
  14. H. Brauer, J. Stolpmann, H. Hallmann, R. Erbel, and A. Fischer, "Measurement and numerical simulation of the dilatation behaviour of coronary stents," Mat.-wiss. U. Werkstofftech, vol. 30, no. 12, pp. 876-885, 1999. https://doi.org/10.1002/(SICI)1521-4052(199912)30:12<876::AID-MAWE876>3.0.CO;2-O
  15. F. Etave, G. Finet, M. Boivin, J. -C. Boyer, G. Rioufol, and G. Thollet, "Mechanical properties of coronary stents determined by using finite element analysis," J. Biomech., vol. 34, no. 8, pp. 1065-1075, 2001. https://doi.org/10.1016/S0021-9290(01)00026-4
  16. F. Ju, Z. Xia, and K. Sasaki, "On the finite element modelling of balloon-expandable stents," J Mech Behav Biomed Mater, vol. 1, no. 1, pp. 86-95, 2008. https://doi.org/10.1016/j.jmbbm.2007.07.002
  17. Sanjay A. Pujari, "Stent Biomechanics in Marginal Coronary Stenotic Arteries," International Journal of Recent Trends in Engineering, vol. 1, no. 2, 2009.
  18. C. Dumoulin, and B. Cochelin, "Mechanical behaviour modelling of balloon-expandable stents," J Biomech., vol. 33, no. 11, pp. 1461-1470, 2000. https://doi.org/10.1016/S0021-9290(00)00098-1