Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Variation of Blood T Lymphocyte Subgroups in Patients with Non- small Cell Lung Cancer

  • Wang, Wen-Jing (Department of Infectious Diseases, Nanjing First Hospital, Nanjing Medical University) ;
  • Tao, Zhen (Department of Infectious Diseases, Nanjing First Hospital, Nanjing Medical University) ;
  • Gu, Wei (Department of Respiration, Nanjing First Hospital, Nanjing Medical University) ;
  • Sun, Li-Hua (Department of Respiration, Nanjing First Hospital, Nanjing Medical University)
  • Published : 2013.08.30
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Abstract

Objectives: To study variation in T lymphocyte subgoups and its clinical significance in non-small cell lung cancer (NSCLC). Methods: Levels of CD3+, CD4+, CD8+, CD4+/CD8+, NK and Treg cells in peripheral blood of NSCLC cases and healthy adults were determined by flow cytometry. Results: CD3+, CD4+ and CD4+/CD8+ ratio and NK cells in NSCLCs were decreased significantly in comparison with the control group (P < 0.01), and decreased with increase in the clinical stage of NSCLC, while CD8+ cells demonstrated no significant change (P > 0.05). Treg cells were significantly more frequent than in the control group (P < 0.01), and increased with the clinical stage of NSCLC. Conclusion: The cellular immune function of the NSCLC patients is lowered. It is important to detect change of T lymphocyte subgroups by flow cytometry for the diagnosis, treatment and prognostic assessment of NSCLC patients.

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References

  1. Dou X, Wang RB, Yan HJ, et al (2013). Circulating lymphocytes as predictors of sensitivity to preoperative chemoradiotherapy in rectal cancer cases. Asian Pac J Cancer Prev, 14, 3881-5. https://doi.org/10.7314/APJCP.2013.14.6.3881
  2. Erdem MG, Cinkilic N, Vatan O, et al (2012). Genotoxic and anti-genotoxic effects of vanillic acid against mitomycin C-induced genomic damage in human lymphocytes in vitro.Asian Pac J Cancer Prev, 13, 4993-8. https://doi.org/10.7314/APJCP.2012.13.10.4993
  3. Hakansson A, Hakansson L, Gustaf sson B, et al (2003). On the effect of biochemotherapy in metastatic malignant melanoma: an unopathological evaluation. Melanoma Res, 13, 401-8. https://doi.org/10.1097/00008390-200308000-00010
  4. Hanaki K, Momo A, Oku T, et al (2003). Semiconductor quantum dot/albumin complex is a long-life and highly photostable endosome marker. Biochem Biophys Res Commun, 302, 496-501. https://doi.org/10.1016/S0006-291X(03)00211-0
  5. Jason D, Marc A, Alexander Y, et al (2003). Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nature Immuno, 4, 330-6. https://doi.org/10.1038/ni904
  6. Karaman H, Karaman A, Erden A, et al (2013). Relationship between colonic polyp type and the neutrophil/ lymphocyte ratio as a biomarker. Asian Pac J Cancer Prev, 14, 3159-61. https://doi.org/10.7314/APJCP.2013.14.5.3159
  7. Liu YC, Zhou SB, Gao F, et al (2013). Chemotherapy and late course three dimensional conformal radiotherapy for treatment of patients with stage III non- small cell lung cancer. Asian Pac J Cancer Prev, 14, 2663-5. https://doi.org/10.7314/APJCP.2013.14.4.2663
  8. Lu YY, Huang XE, Xu L, et al (2013). Potential predictors of sensitivity to pemetrexed as first-line chemotherapy for patients with advanced non-squamous NSCLCs. Asian Pac J Cancer Prev, 14, 2005-8. https://doi.org/10.7314/APJCP.2013.14.3.2005
  9. Manni JA, Guilleron C, Araujo HA, et al (1989). Lymphocyte imbalance in autoimmunity. Medicina B Aires, 49, 105-8.
  10. Mattes J, Hulett M, Xie W, et al (2003). Immunotherapy of cytotoxic T cell resist ant tumors by T helper 2 cells: an eot axin and AT dependent process. J Exp Med, 197, 387- 93. https://doi.org/10.1084/jem.20021683
  11. Mitropoulos D, Alamanis C, Deliveliotts C, et al (1995).T- lymphocyt e subgoups in the peripheral blood of patients with renal cell carcinoma. Arta Urol Belg, 63, 21-5.
  12. Nakamura H, Kawasaki N, Hagiwara M, et al (2000). Cellular immunologic parameters related to age, gender, and stage in lung cancer patients. Lung Cancer, 28, 139-45. https://doi.org/10.1016/S0169-5002(99)00133-6
  13. Nugroho AE, Hermawan A, Nastiti K, (2012). Immunomodulatory effects of hexane insoluble fraction of Ficus septica Burm. F. in doxorubicin-treated rats. Asian Pac J Cancer Prev, 13, 5785-90. https://doi.org/10.7314/APJCP.2012.13.11.5785
  14. Parkin DM, Brary FB, Pisani P (2005). Global cancer statistics. Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  15. Wing K, Lindgren S, Kollberg G, et al (2003). CD4+ T cell activation by myelinoligodendrocyte glycoprot ein is suppressed by adult but not cord blood CD4+ T cells. Eur J Immunol, 33, 579-87. https://doi.org/10.1002/eji.200323701

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