DOI QR코드

DOI QR Code

Genetic Deletions of GSTM1 and GSTT1 in Head and Neck Cancer: Review of the Literature from 2000 to 2012

  • Masood, Nosheen (Environmental Sciences Department, Fatima Jinnah Women University) ;
  • Yasmin, Azra (Environmental Sciences Department, Fatima Jinnah Women University) ;
  • Kayani, Mahmood A. (Department of Biosciences, COMSATS Institute of Information Technology)
  • Published : 2013.06.30

Abstract

Head and neck cancer is one of the leading causes of deaths worldwide. Two genes GSTM1 and GSTT1 involved in phase II of carcinogen detoxification have been frequently studied in the literature. Their null genotypes are thought to be associated with increased head and neck cancer risk. However, the published reviews are not up to date and many important papers have been skipped. The current literature review was restricted to the null genotypes of the GSTM1 and GSTT1 genes with special emphasis on the genotypic status. We found that the size of study sample varied greatly and the oral cavity cancer was more influenced by GSTM1 and GSTT1 gene deletions. With respect to ethnicity Asians are more prone to head and neck cancers with these null genotypes as compared to Europeans and Americans. The current review showed significant associations (OR=9.0, 95%CI; 1.4-9.5; OR=3.7, 95%CI; 1.4-9.5) of GSTM1 and GSTT1 null genotypes with head and neck cancers. Review confirms the data of previous reviews that GSTM1 and GSTT1 gene polymorphisms may be risk factors for cancer initiation.

Keywords

References

  1. Acar H, Ozturk K, Muslumanoglu MH, et al (2006). Relation of glutathione S-transferase genotypes (GSTM1 and GSTT1) to laryngeal squamous cell carcinoma risk. Cancer Genet Cytogenet, 169, 89-93. https://doi.org/10.1016/j.cancergencyto.2005.12.007
  2. Amtha R, Ching CS, Zain R, et al (2009). GSTM1, GSTT1 and CYP1A1 polymorphisms and risk of oral cancer: a casecontrol study in Jakarta, Indonesia. Asian Pac J Cancer Prev, 10, 21-6.
  3. Anantharaman D, Chaubal PM, Kannan S, Bhisey RA, Mahimkar MB (2007). Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator. Carcinogenesis, 28, 1455-62. https://doi.org/10.1093/carcin/bgm038
  4. Bardakci F, Canbay E, Degerli N, Coban L (2003). Relationship of tobacco smoking with GSTM1 gene polymorphism in laringeal cancer. J Cell Mol Med, 7, 307-12. https://doi.org/10.1111/j.1582-4934.2003.tb00231.x
  5. Bendjemana K, Abdennebi M, Gara S, et al (2006). Genetic polymorphism of gluthation-S transferases and N-acetyl transferases 2 and nasopharyngeal carcinoma: the Tunisia experience. Bull Cancer, 93, 297-302.
  6. Bhurgri Y, Bhurgri A, Usman A, et al (2006). Epidemiological review of head and neck cancers in Karachi. Asia Pac J Cancer Prev, 7, 195-200.
  7. Biselli JM, de Angelo Calsaverini Leal RC, Ruiz MT, et al (2006). GSTT1 and GSTM1 polymorphism in cigarette smokers with head and neck squamous cell carcinoma. Braz J Otorhinolaryngol, 72, 654-8.
  8. Boccia S, Cadoni G, Sayed-Tabatabaei FA, et al (2008). CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer. J Cancer Res Clin Oncol, 134, 93-100.
  9. Buch SC, Perin N (????). Notani and Rajani A. Bhisey Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population. Carcinogenesis, 23, 803-7.
  10. Cabelguenne A, Loriot MA, Stucker I, et al (2001). Glutathioneassociated enzymes in head and neck squamous cell carcinoma and response to cisplatinbased neoadjuvant chemotherapy. Int J Cancer, 93, 725-30. https://doi.org/10.1002/ijc.1392
  11. Cadoni G, Boccia S, Petrelli L, et al (2012). A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism. ACTA Otorhinolaryngologica Ita Lica, 32, 1-11.
  12. Capoluongo E, Almadori G, Concolino P, et al (2007). GSTT1 and GSTM1 allelic polymorphisms in head and neck cancer patients from Italian Lazio Region. Clin Chim Acta, 376, 174-8. https://doi.org/10.1016/j.cca.2006.08.017
  13. Cha IH, Park JY, Chung WY, et al (2007). Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer. Yonsei Med J, 48, 233-9. https://doi.org/10.3349/ymj.2007.48.2.233
  14. Cheng L, Sturgis EM, Eicher SA, et al (1999). Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck. Int J Cancer, 84, 220-4. https://doi.org/10.1002/(SICI)1097-0215(19990621)84:3<220::AID-IJC4>3.0.CO;2-S
  15. Deng ZL, Yi-Ping Wei, Yun Ma (2005). Polymorphism of glutathione S-transferase mu 1 and theta 1 genes and hepatocellular carcinoma in southern Guangxi, China. World J Gastroenterol, 11, 272-4 https://doi.org/10.3748/wjg.v11.i2.272
  16. Drummond SN, De Marco L, Noronha JC, Gomez RS (2004). GSTM1 polymorphism and oral squamous cell carcinoma. Oral Oncol, 40, 52-5. https://doi.org/10.1016/S1368-8375(03)00132-5
  17. Egan KM, Cai Q, Shu XO, et al (2004). Genetic polymorphisms in GSTM1, GSTP1 and GSTT1 and the risk for breast cancer, results from Shanghai breast cancer study and meta analysis. Cancer Epidemiol Bio Prev, 13, 197-204. https://doi.org/10.1158/1055-9965.EPI-03-0294
  18. Evans AJ, Henner WD, Eilers KM, et al (2004). Polymorphisms of GSTT1 and related genes in head and neck cancer risk. Head Neck, 26, 63-70. https://doi.org/10.1002/hed.10342
  19. Gajecka M, Rydzanicz M, Jaskula-Sztul R, et al (2005). CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma. Mutat Res, 574, 112-23. https://doi.org/10.1016/j.mrfmmm.2005.01.027
  20. Gatta's GJ, de Carvalho MB, Siraque MS, et al (2006). Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer. Head Neck, 28, 819-26. https://doi.org/10.1002/hed.20410
  21. Gaudet MM, Olshan AF, Poole C, et al (2004). Diet, GSTM1 and GSTT1 and head and neck cancer. Carcinogenesis, 25, 735-40.
  22. Gronau S, Koenig-Greger D, Jerg M, Riechelmann H (2003). GSTM1 enzyme concentration and enzyme activity in correlation to the genotype of detoxification enzymes in squamous cell carcinoma of the oral cavity. Oral Dis, 9, 62-7. https://doi.org/10.1034/j.1601-0825.2003.02866.x
  23. Guo X, Stephen J, O'Brien, et al (2008). GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese. Cancer Epidemiol Biomarkers Prev, 17, 1760-3. https://doi.org/10.1158/1055-9965.EPI-08-0149
  24. Hahn M, Hagedorn G, Kuhlisch E, Schackert HK, Eckelt U (2002). Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer. Oral Oncol, 38, 486-90. https://doi.org/10.1016/S1368-8375(01)00086-0
  25. Hamel N, Karimi S, He'bert-Blouin MN, et al (2000). Increased risk of head and neck cancer in association with GSTT1 nullizygosity for individuals with low exposure to tobacco. Int J Cancer, 87, 452-4. https://doi.org/10.1002/1097-0215(20000801)87:3<452::AID-IJC22>3.0.CO;2-W
  26. Hanna E, MacLeod S, Vural E, Lang N (2001). Genetic deletions of glutathione-S-transferase as a risk factor in squamous cell carcinoma of the larynx: a preliminary report. Am J Otolaryngol, 22, 121-3. https://doi.org/10.1053/ajot.2001.22571
  27. Hayes JD, Pulford DJ (1995). The glutathione S-transferase supergene family, regulation of GST and the contribution of isoenzymes to cancer chemoprevention and drug resistance. Crit Rev Biochem Mol Biol, 30, 445-600. https://doi.org/10.3109/10409239509083491
  28. Hong YJ, Lee JK, Lee GH, et al (2000). Influence of glutathione Stransferase M1 and T1 genotypes on larynx cancer risk among Korean smokers. Clin Chem Lab Med, 38, 917-9.
  29. Jun T, Ming Y, Xin N, et al (2010). Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population. Cancer Genet Cytogenet, 196, 76-82. https://doi.org/10.1016/j.cancergencyto.2009.08.015
  30. Kietthubthew S, Sriplung H, Au WW (2001). Genetic and environmental interactions on oral cancer in Southern Thailand. Environ Mol Mutagen, 37, 111-6. https://doi.org/10.1002/em.1018
  31. Ko Y, Abel J, Harth V, et al (2001). Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue. Cancer Res, 61, 4398-404.
  32. Leme CV, Raposo LS, Ruiz MT, et al (2010). GSTM1 and GSTT1 genes analysis in head and neck cancer patients. Rev Assoc Med Bras, 56, 299-303. https://doi.org/10.1590/S0104-42302010000300013
  33. Majumder M, Sikdar N, Paul RR, et al (2005). Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers carrying two risk genotypes: one on each of two loci, GSTM3 and XRCC1 (codon 280). Cancer Epidemiol Biomarkers Prev, 14, 2106-12. https://doi.org/10.1158/1055-9965.EPI-05-0108
  34. Masood N, Ishrat M, Malik FA, Kayani MA (2010). Association of GSTM1 and GSTT1 gene deletions with head and neck cancer in Pakistan: a case control study. Asian Pac J Cancer Prev, 11, 881-5.
  35. McWilliams JE, Evans AJ, Beer TM, et al (2000). Genetic polymorphisms in head and neck cancer risk. Head Neck, 22, 609-17. https://doi.org/10.1002/1097-0347(200009)22:6<609::AID-HED10>3.0.CO;2-L
  36. Nomura S, Sugano K, Kashiwabara H, et al (2000). Enhanced detection of deleterious and other germline mutations of hMSH2 and hMLH1 in Japanese hereditary nonpolyposis colorectal cancer kindreds. Biochem Biophys Res Commun, 271, 120-9. https://doi.org/10.1006/bbrc.2000.2547
  37. Olshan AF, Weissler MC, Watson MA, Bell DA (2000). GSTM1, GSTT1, GSTP1, CYP1A1, and NAT1 polymorphisms, tobacco use, and the risk of head and neck cancer. Cancer Epidemiol Biomarkers Prev, 9, 185-91.
  38. Oude Ophuis MB, van Lieshout EM, Roelofs HM, Peters WH, Manni JJ (1998). Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions. Cancer, 82, 936-43. https://doi.org/10.1002/(SICI)1097-0142(19980301)82:5<936::AID-CNCR20>3.0.CO;2-0
  39. Park JY, Muscat JE, Kaur T, et al (2000). Comparison of GSTM polymorphisms and risk of oral cancer between African-American and caucasians. Pharmacogenetics, 10, 123-31. https://doi.org/10.1097/00008571-200003000-00004
  40. Park JY, Muscat JE, Ren Q, et al (2009). CYP1A1 and GSTM1 polymorphisms and oral cancer risk. Cancer Epidemiol Biomarkers Prev, 6, 791-7.
  41. Peters ES, McClean MD, Marsit CJ, Luckett B, Kelsey KT (2006). Glutathione S-transferase polymorphisms and the synergy of alcohol and tobacco in oral, pharyngeal, and laryngeal carcinoma. Cancer Epidemiol Biomarkers Prev, 15, 2196-202. https://doi.org/10.1158/1055-9965.EPI-06-0503
  42. Risch A, Ramroth H, Raedts V, et al (2003). Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1. Pharmacogenetics, 13, 225-30. https://doi.org/10.1097/00008571-200304000-00007
  43. Sato M, Sato T, Izumo T, Amagasa T (2000). Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes. Oral Oncol, 36, 267-71. https://doi.org/10.1016/S1368-8375(99)00090-1
  44. Schneider J, Bernges U, Philipp M, et al (2004). GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking. Cancer Lett, 208, 65-74. https://doi.org/10.1016/j.canlet.2004.01.002
  45. Sharma A, Mishra A, Das BC, Sardana S, Sharma JK (2006). Genetic polymorphism at GSTM1 and GSTT1 gene loci and susceptibility to oral cancer. Neoplasma, 53, 309-15.
  46. Sikdar N, Sila D, Badal D, et al (2005). Homozygous null genotype at glutathione S-transferase M1 locus as a risk factor for oral squamous cell carcinoma in Indian tobacco users. Int J Hum Genet, 5, 37-44.
  47. Sreelekha TT, Ramadas K, Pandey M, et al (2001). Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer. Oral Oncol, 37, 593-8. https://doi.org/10.1016/S1368-8375(01)00028-8
  48. Sugimura T, Kumimoto H, Tohnai I, et al (2006). Geneenvironment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. J Oral Pathol Med, 35, 11-8. https://doi.org/10.1111/j.1600-0714.2005.00364.x
  49. Tiwawech D, Srivatanakul P, Karalak A, Ishida T (2005). Glutathione S-transferase M1 gene polymorphism in Thai nasopharyngeal carcinoma. Asian Pac J Cancer Prev, 6, 270-5.
  50. To-Figueras J, Gene' M, Go'mez-Catala'n J, et al (2002). Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk. Cancer Lett, 187, 95-101. https://doi.org/10.1016/S0304-3835(02)00406-8
  51. Toefil L, Oana CT, Horea AA, et al (2007). Head and neck cancer, epidemiology and histological aspects-Part 1, A decades results 1993-2003. J Cranio Maxill Surg, 35, 120-5. https://doi.org/10.1016/j.jcms.2007.02.001
  52. Topcu Z, Chiba I, Fujieda M, et al (2002). CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka. Carcinogenesis, 23, 595-8. https://doi.org/10.1093/carcin/23.4.595
  53. Toru H, Masaharu Y, Shinji T, et al (2008). Genetic polymorphisms and head and neck cancer risk. Int J Oncol, 32, 945-73.
  54. Unal M, Tamer L, Ates NA, et al (2004). Glutathione S-transferase M1, T1, and P1 gene polymorphism in laryngeal squamous cell carcinoma. Am J Otolaryngol, 25, 318-22. https://doi.org/10.1016/j.amjoto.2004.04.003
  55. Varela-Lema L, Taioli E, Ruano-Ravina A, et al (2008). Metaanalysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a huge-GSEC review. Genet Med, 10, 369-84. https://doi.org/10.1097/GIM.0b013e3181770196
  56. Xie H, Hou L, Shields PG, et al (2004). Metabolic polymorphisms, smoking, and oral cancer in Puerto Rico. Oncol Res, 14, 315-20.

Cited by

  1. Null Glutathione S-transferase T1 and M1 Genotypes and Oral Cancer Susceptibility in China and India - a Meta-analysis vol.15, pp.1, 2014, https://doi.org/10.7314/APJCP.2014.15.1.287
  2. Prognostic Significance of Altered Blood and Tissue Glutathione Levels in Head and Neck Squamous Cell Carcinoma Cases vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7603
  3. Genetic Susceptibility to Oral Cancer due to Combined Effects of GSTT1, GSTM1 and CYP1A1 Gene Variants in Tobacco Addicted Patients of Pashtun Ethnicity of Khyber Pakhtunkhwa Province of Pakistan vol.16, pp.3, 2015, https://doi.org/10.7314/APJCP.2015.16.3.1145
  4. Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population vol.36, pp.8, 2015, https://doi.org/10.1007/s13277-015-3246-0
  5. Association of CYP1A1 and GSTM1 Polymorphisms With Oral Cancer Susceptibility vol.94, pp.27, 2015, https://doi.org/10.1097/MD.0000000000000895
  6. are associated with head and neck cancer risk? pp.1366-5804, 2019, https://doi.org/10.1080/1354750X.2018.1556337