Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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MCM3 as a Novel Diagnostic Marker in Benign and Malignant Salivary Gland Tumors

  • Ashkavandi, Zohreh Jaafari (Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences) ;
  • Najvani, Ali Dehghani (Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences) ;
  • Tadbir, Azadeh Andishe (Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences) ;
  • Pardis, Soheil (Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences) ;
  • Ranjbar, Mohammad Ali (Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences) ;
  • Ashraf, Mohammad Javad (Department of Pathology, Medical School, Shiraz University of Medical Sciences)
  • Published : 2013.06.30
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Abstract

Background: Proliferation markers widely have been used to diagnose and determine the behaviour and prognosis of benign and malignant tumours. Minichromosome maintenance 3 (MCM3) is a novel proliferation marker. The aim of this study was to evaluate and compare MCM3 with Ki-67 in diagnosis of salivary gland tumours. Materials and Methods: In this retrospective study, immunohistochemical expression of MCM3 and Ki-67 was evaluated in 15 pleomorphic adenomas (PA), 17 mucoepidermoid carcinomas (MEC) and 18 adenoid cystic carcinomas (ADCC). Labeling indices (LIs) for the two markers were calculated and compared. Results: MCM3 and Ki-67 LIs were significantly higher in MEC and ADCC compared to PA. The LI of MCM3 was significantly higher than that of Ki-67 in MEC and PA. There was no significant difference between the two markers in ADCC. A cut-off point of 8% with 74.3% sensitivity and 93.3% specificity for MCM3 was obtained to discern between benign and malignant tumors. Conclusions: These results suggest that MCM3 might be a useful proliferation marker for differential diagnosis and recognition of clinical behavior of salivary gland tumors.

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References

  1. Agarwal JP, Jain S,Gupta T, et al (2008). Intraoral adenoid cystic carcinoma: prognostic factors and outcome. Oral Oncol, 44, 986-93. https://doi.org/10.1016/j.oraloncology.2008.01.004
  2. Alison MR, Hunt T, Forbes SJ (2002). Minichromosome maintenance (MCM) proteins may be pre-cancer markers. Gut, 50, 290-1. https://doi.org/10.1136/gut.50.3.290
  3. Brown DC, Gatter KC (2002). Ki67 protein: the immaculate deception? Histopathol, 40, 2-11. https://doi.org/10.1046/j.1365-2559.2002.01343.x
  4. Chevalier S, Blow JJ (1996). Cell cycle control of replication initiation in eukaryotes. Curr Opin Cell Biol, 8, 815-21. https://doi.org/10.1016/S0955-0674(96)80082-2
  5. Constantinos G, Stephanie V, Philippe V, Stamatios T (2010). MCM proteins as diagnostic and prognostic tumor marker in the clinical setting. Histol Histopathol, 25, 351-70.
  6. de Andrade BA, Leon JE, Carlos R, et al (2012). Expression of minichromosome maintenance 2, Ki-67, and geminin in oral nevi and melanoma. Ann Diag Pathol, 17, 32-6.
  7. Forsburg SL (2004). Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev, 68, 109-31. https://doi.org/10.1128/MMBR.68.1.109-131.2004
  8. Freeman A, Morris LS, Mills AD, et al (1999). Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res, 5, 2121-32.
  9. Ghazy SE, Helmy IM, Baghdadi HM (2011). Maspin and MCM2 immunoprofiling in salivary gland carcinomas. Diagn Pathol, 6, 89. https://doi.org/10.1186/1746-1596-6-89
  10. Gonzalez MA, Pinder SE, Callagy G, et al (2003). Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer. J Clin Oncol, 21, 4306-13. https://doi.org/10.1200/JCO.2003.04.121
  11. Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA (2005). Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. Int J Oral Maxillofac Surg, 34, 533-6. https://doi.org/10.1016/j.ijom.2005.02.005
  12. Kodani I, Shomori K, Osaki M, et al (2001). Expression of minichromosome maintenance 2(MCM2), Ki-67,and cell-cycle- related molecules, and apoptosis in the normal-dysplasia-carcinoma sequence of the oral mucosa. Pathobiology, 69, 150-8. https://doi.org/10.1159/000048770
  13. Korkolopoulou P, Givalos N, Saetta A, et al (2005). Minichromosome maintenance proteins 2 and 5 expression in muscle-invasive urothelial cancer: a multivariate survival study including proliferation markers and cell cycle regulators. Hum Pathol, 36, 899-907. https://doi.org/10.1016/j.humpath.2005.06.008
  14. Li J, Deng M, Wei Q, Liu T, et al (2011). Phosphorylation of MCM3 protein by cyclin E/cyclin-dependent kinase 2 (Cdk2) regulates its function in cell cycle. J Biol Chem, 46, 39776-85.
  15. Mac Callum DE, Hall PA (2000). The location of PKI67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle. J Pathol, 190, 537-44. https://doi.org/10.1002/(SICI)1096-9896(200004)190:5<537::AID-PATH577>3.0.CO;2-W
  16. Meng MV, Grossfeld GD, Williams GH, et al (2001). Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer. Clin Cancer Res, 7, 2712-8.
  17. Liu M, Li JS, Tian DP, et al (2013). MCM2 expression levels predict diagnosis and prognosis in gastric cardiac cancer. Histol Histopathol, 28, 481-92.
  18. Nagao T, Sato E, Inoue R, et al (2012). Immunohistochemical analysis of salivary gland tumors: application for surgical pathology practice. Acta Histochem Cytochem, 45, 269-82. https://doi.org/10.1267/ahc.12019
  19. Nurhan G, Nil C, Fatih C (2012). Ki-67 and MCM-2 in dental follicle and odontogenic cysts: the effects of inflammation on proliferative markers. Sci World J, [Epub ahead of print].
  20. Pich A, Chiusa L, Navone R (2004). Prognostic relevance of cell proliferation in head and neck tumors. Ann Oncol, 15, 1319-29. https://doi.org/10.1093/annonc/mdh299
  21. Speight P, Barrett A (2004). Salivary gland tumors. Oral Dis, 8, 229-40.
  22. Szelachowska J, Dziegiel P, Jelen-Krzeszewska J, et al (2006). Jelen M, Matkowski R, Pomiencko A, et al. MCM-2 protein expression predicts prognosid better than ki-67 antigen in oral cavity squamocellular carcinoma. Anticancer Ref, 26, 2473-8.
  23. Tadbir AA, Pardis S, Ashkavandi ZJ, et al (2012). Expression of Ki67 and CD105 as proliferation and angiogenesis markers in salivary gland tumors. Asian Pas J Cancer Prev, 13, 5155-9. https://doi.org/10.7314/APJCP.2012.13.10.5155
  24. Van Diest PJ, vander Wall E, Baak JP (2004). Prognostic value of proliferation in invasive breast cancer: a review. J Clin Pathol, 57, 675-81. https://doi.org/10.1136/jcp.2003.010777
  25. Van Oijen MG, Medema RH, Slootweg PJ, Rijksen G (1998). Positivity of the proliferation marker Ki-67 in noncycling cells. Am J Clin Pathol, 110, 24-31.
  26. Vargas P, Cheng W, Barrett A, Craig G, Speight P (2008). Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumors. J Oral Pathol Med, 37, 309-18. https://doi.org/10.1111/j.1600-0714.2007.00631.x
  27. Yang C, Wen Y, Li H, et al (2011). Overexpression of minichro mosome maintenance 2 predicts poor prognosis in patients with gastric cancer. Oncol Rep, 27, 135-42
  28. Youn SL, Seon-Ah Ha, Hae JK, et al (2010). Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma. Exp Mol Pathol, 88, 138-42. https://doi.org/10.1016/j.yexmp.2009.09.015

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