Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Protective effects of a mineral aqueous solution on toxicity in mouse liver and kidney

  • Park, In-Jae (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonosis Research Institute, Chonbuk National University) ;
  • Cha, Se-Yeoun (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonosis Research Institute, Chonbuk National University) ;
  • Kang, Min (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonosis Research Institute, Chonbuk National University) ;
  • So, Yang-Sub (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonosis Research Institute, Chonbuk National University) ;
  • Bahng, Ji-Yun (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonosis Research Institute, Chonbuk National University) ;
  • Jang, Hyung-Kwan (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonosis Research Institute, Chonbuk National University)
  • Received : 2013.03.27
  • Accepted : 2013.08.08
  • Published : 2013.09.30
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Abstract

We demonstrated that a mineral aqueous solution (MAS) administered to mice functionally and histologically protected against cisplatin-induced acute renal failure (ARF) and $CCl_4$-induced acute liver failure (ALF). In ARF model, 0.4 and 0.2% MAS decreased mortality and the serum concentrations of blood urea nitrogen (BUN) and creatine in mice. Additionally, 0.4 and 0.2% MAS reduced contraction of distal convoluted tubules and suppressed expression of the proinflammatory cytokines interlukein-6 (IL-6) and tumor necrosis factor (TNF-${\alpha}$) in the kidney. In ALF model, 0.4 and 0.2% MAS decreased serum concentrations of alanine aminotransferase and aspartate aminotransferase in mice. Additionally, 0.4 and 0.2% MAS reduced necrotic areas and suppressed expression of IL-6 and TNF-${\alpha}$ in the liver. These results indicate that a MAS might have protective effects against ARF and ALF.

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References

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