Journal of the Korean Society of Physical Medicine (대한물리의학회지)

The Korean Society of Physical Medicine (대한물리의학회)
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Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat

저강도 맥동초음파에의한 피부 상처 치유 촉진과 아교질 축적 및 아교질 mRNA 발현 증가

  • Lee, Jae-Hyoung (Dept. of Physical Therapy, Electrotherapy Research Laboratory for Tissue Growth & Repair, Wonkwang Health Science University) ;
  • Jeka, Seung-Joo (Dept. of Clinical Laboratory Science, Wonkwang Health Science University) ;
  • Kwon, Pil-Seung (Dept. of Clinical Laboratory Science, Wonkwang Health Science University)
  • Received : 2013.07.31
  • Accepted : 2013.08.19
  • Published : 2013.08.31
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Abstract

목적: 본 연구는 저강도 맥동 초음파적용이 흰쥐의 전층 상처 치유와 아교질 축적 및 아교질 mRNA발현에 미치는 영향을 규명할 목적으로 시행하였다. 방법: 12마리의 Sprague-Dawley계 흰쥐를 저강도 맥동 초음파군(n=6)과 대조군(n=6)에 무작위 배정하고 등에 $19.63mm^2$ 크기의 전층 적출 상처를 만든 다음 저강도 맥동 초음파군은 3 MHz, 순환주기 20%, SATA 강도 $0.4W/cm^2$로 1일 1회, 1회 5분씩 초음파를 적용하고, 대조군은 가짜 초음파를 적용하였다. 7일간 처치 후 초음파군과 대조군의 아교질 축적, 아교질 mRNA 발현, 상처치유율, 절반치유시간을 비교하였다. 결과: 초음파군의 아교질 축적(p<05)과 아교질 mRNA 발현(p<.01)이 대조군보다 유의하게 증가하였고, 상처치유율(p<.05)과 절반치유시간(p<.0)도 초음파군의 대조군보다 유의하게 빨랐다. 결론: 본 연구에서 전층 상처에 저강도 맥동 초음파를 적용한 결과 상처 치유가 촉진되었고 육아조직에 아교질 축적이 증가하였다. 이러한 결과는 맥동 초음파의 기계적 자극이 제 1형 아교질 mRNA 전사활동을 촉진시키는 것으로 사료된다.

Keywords

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