Nutrition Research and Practice

  • 제7권5호
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  • Pages.373-379
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  • 2013
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  • 1976-1457(pISSN)
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  • 2005-6168(eISSN)
한국영양학회 (The Korean Nutrition Society)
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Effect of onion peel extract supplementation on the lipid profile and antioxidative status of healthy young women: a randomized, placebo-controlled, double-blind, crossover trial

  • Kim, Jungmi (Department of Food and Nutrition, Kyungnam University) ;
  • Cha, Yong-Jun (Department Food and Nutrition, Changwon National University) ;
  • Lee, Kyung-Hea (Department Food and Nutrition, Changwon National University) ;
  • Park, Eunju (Department of Food and Nutrition, Kyungnam University)
  • 투고 : 2012.08.06
  • 심사 : 2013.06.04
  • 발행 : 2013.10.01
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초록

The consumption of fruits and vegetables that have high polyphenol content has been previously associated with a reduced risk for cardiovascular disease. We investigated the effects of onion peel extract on plasma total antioxidant capacity, lipid peroxidation, and leukocyte DNA damage. This study was a randomized, double-blind, placebo-controlled, crossover trial. Healthy female subjects received either onion peel extract or placebo (dextrin) for two weeks, underwent a 1-week washout period, and then received the other treatment for an additional two weeks. After two weeks of onion peel extract supplementation, the total cholesterol level, low-density lipoprotein cholesterol level, and atherogenic index significantly decreased (P < 0.05). No changes were observed in activities of erythrocyte antioxidant enzymes or levels of lipid peroxidation markers following onion peel extract supplementation. Additionally, no significant difference was found in plasma antioxidant vitamin (retinol, tocopherols, carotenoids, and coenzyme Q10) levels or ex vivo $H_2O_2$-provoked oxidative DNA damage after onion peel extract supplementation. The present interventional study provides evidence of the health benefits of onion peel extract and demonstrates its effects in modulating lipid profiles in healthy young Korean women.

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  4. Onion peel extract reduces the percentage of body fat in overweight and obese subjects: a 12-week, randomized, double-blind, placebo-controlled study vol.10, pp.2, 2016, https://doi.org/10.4162/nrp.2016.10.2.175
  5. The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women vol.5, pp.4, 2016, https://doi.org/10.7762/cnr.2016.5.4.261
  6. Impact of Flavonols on Cardiometabolic Biomarkers:  A Meta‐Analysis of Randomized Controlled Human  Trials to Explore the Role of Inter‐Individual  Variability vol.9, pp.2, 2017, https://doi.org/10.3390/nu9020117
  7. Clinical effectiveness of quercetin supplementation in the management of weight loss: a pooled analysis of randomized controlled trials vol.12, pp.None, 2019, https://doi.org/10.2147/dmso.s199830
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  9. Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation vol.25, pp.2, 2013, https://doi.org/10.3390/molecules25020318
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