Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effect of Essential Oil from San-Jo-In (Zizyphus jujuba Mill. seeds) on Human Electroencephalographic Activity

산조인(Zizyphus jujuba Mill.) 에센셜오일 흡입이 인간의 뇌파에 미치는 영향

  • Cho, Haeme (Department of Biological Environment, Kangwon National University) ;
  • Yu, Byoungsun (Department of Biological Environment, Kangwon National University) ;
  • Sowndhararajan, Kandhasamy (Department of Biological Environment, Kangwon National University) ;
  • Jung, Ji-Wook (Department of Herbal Medicinal Pharmacology, Daegu Haany University) ;
  • Jhoo, Jin-Woo (Department of Animal Products and Food Science, Kangwon National University) ;
  • Kim, Songmun (Department of Biological Environment, Kangwon National University)
  • Received : 2013.08.12
  • Accepted : 2013.09.23
  • Published : 2013.09.30
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Abstract

Essential oils have been used to treat psychophysiological disorders, but their effects on human electroencephalographic (EEG) activity have not been thoroughly investigated. We evaluated the effects of essential oil of Zizyphus jujuba seeds, a Korean folk medicine known as San-Jo-In, on human EEG activity. For this purpose, essential oil was extracted from San-Jo-In by the supercritical carbon dioxide extraction method. The effect of its inhalation on EEG activity was evaluated by measuring the EEG power spectrum (25 indices) in 20 healthy participants. The results of the EEG power spectrum indicated that the values of the theta wave decreased significantly (p<0.05) in the left (from 17.277 to $13.854{\mu}V$) and right parietal (from 15.324 to $13.020{\mu}V$) regions compared to the other regions. During the inhalation of San-Jo-In oil, the EEG spectrum values of fast alpha, relative gamma, and spectral edge frequency increased 50% compared to those before inhalation. The values of the fast alpha wave increased significantly (p<0.05) in the left prefrontal (from 0.063 to $0.085{\mu}V$), right prefrontal (from 0.064 to $0.085{\mu}V$), and left frontal (from 0.073 to $0.100{\mu}V$) regions following inhalation of the San-Jo-In essential oil. The changes in the EEG activities following inhalation of San-Jo-In suggest that the oil can improve psychological well-being by increasing attention and relaxation.

에센셜오일은 신경생리학적 장애의 치료에 오랜동안 사용되었지만 아직까지 그 효능이 과학적으로 구명되지 않았다. 저자들은 한의학에서 산조인으로 알려져 있는 Zizyphus jujuba 종자의 에센션오일이 인간의 뇌파에 미치는 영향을 연구하였다. 초임계이산화탄소추출법을 이용하여 산조인으로부터 에센셜오일을 얻고, 20명의 피험자를 대상으로 EEG 파워 스펙트럼을 측정하였다. 산조인 에센셜오일 흡입 전과 흡입 중 다른 부위와 비교하여 theta파가 좌측 두정엽 부위($17.277{\rightarrow}13.854{\mu}V$)와 우측 두정엽 부위($15.324{\rightarrow}13.020{\mu}V$)에서 통계학적으로 차이를 나타내었다(p<0.05). 산조인 정유 흡입으로 fast alpha 파, relative gamma 파, spectral edge frequency 50% 지수가 증가하였는데, 이들 지수 중 fast alpha 파는 좌측 전전두엽 부위($0.063{\rightarrow}0.08{\mu}V$), 우측 전전두엽 부위($0.064{\rightarrow}0.085{\mu}V$), 그리고 좌측 두정엽 부위($0.073{\rightarrow}0.100{\mu}V$)에서 통계학적으로 차이를 나타내었다. 본 연구의 결과는 산조인 에센셜오일 흡입에 의한 EEG 변화는 두뇌기능 중 각성과 진정상태를 증가시켜 인간의 심리학적인 조건을 향상시킨다는 것을 추론하게 한다.

Keywords

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