The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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The study on pharmacologic activation as cosmetic material of Sanguisorbae radix

지유(地榆)의 화장품 소재로서의 약리활성에 관한 연구

  • Jang, Young-Ah (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Kim, Young-Hun (Gennolab Co. Ltd.) ;
  • Shin, Jae-Cheon (Pohang Center for Evaluation of Biomaterials) ;
  • Han, Sang-Ik (Functional Crop Resource Development Div., National Institute of Crop Science) ;
  • Lee, Jin-Tae (Department of Cosmeceutical Science, Daegu Haany University)
  • 장영아 (대구한의대학교 화장품약리학과) ;
  • 김영훈 ((주)제노랩) ;
  • 신재천 ((재)포항테크노파크 바이오정보지원센터) ;
  • 한상익 (국립식량과학원) ;
  • 이진태 (대구한의대학교 화장품약리학과)
  • Received : 2013.08.15
  • Accepted : 2013.09.17
  • Published : 2013.09.30
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Abstract

Objectives : This study was aimed at producing emulsion by using butanol fractions of Sanguisorbae radix(SRA-B) which have high antioxidative and anti-inflammatory actions, and then evaluating stabilities of the emulsion. Methods : We measured antioxidant efficacy of SRA-B by using DPPH assay. Also, we checked the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) by using the Western blot to evaluate the anti-inflammatory effects of SRA-B3. We prepared emulsion containing SRA-B3(E-SRA-B3) and analysed its particle size distribution under a microscope. Also, we performed the test for stability of the emulsion. Results : SRA-B3 showed the highest efficacy in electronic donating abilities' activity. The Western blot's results indicated that the protein expression's amount of iNOS and COX-2 in macrophage stimulated by LPS were reduced by SRA-B3 treatment. The average particle size of E-SRA-B3 was $5{\sim}6{\mu}m$ in diameter and was $6.7{\mu}m$ in a view of the particle distribution. For a period of a observation, E-SRA-B3 has not made particular changes with storage temperature. It was observed that E-SRA-B3 could preserve its stable condition without a particular difference of viscosity during 28 days. Conclusions : From the above results, it was confirmed that SRA-B3 has potentiality enough to be applied to industrialization and could be utilized as antioxidative natural materials and anti-inflammatory cosmetics.

Keywords

References

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