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Safety Evaluation of 30 kGy-Irradiated Dakgalbi

30 kGy 감마선 조사된 닭갈비의 안전성 평가

  • Jeon, Young Eun (Dept. of Food Science and Nutrition & Life Science, Hallym University) ;
  • Yin, Xing Fu (Dept. of Food Science and Nutrition & Life Science, Hallym University) ;
  • Kim, Tae-Keun (Dept. of Food Science and Nutrition & Life Science, Hallym University) ;
  • Kang, Il-Jun (Dept. of Food Science and Nutrition & Life Science, Hallym University)
  • 전영은 (한림대학교 식품영양학과.생명과학과) ;
  • 윤성복 (한림대학교 식품영양학과.생명과학과) ;
  • 김태근 (한림대학교 식품영양학과.생명과학과) ;
  • 강일준 (한림대학교 식품영양학과.생명과학과)
  • Received : 2013.05.20
  • Accepted : 2013.05.27
  • Published : 2013.09.30

Abstract

The aim of this study was to determine the potential toxicity of gamma-irradiated Dakgalbi keeping in mind its future use as a space food. Dakgalbi was irradiated at a dose of 30 kGy at $-20^{\circ}C$. AIN-93G was used as a control diet in the animal study. Both irradiated and non-irradiated Dakgalbi diets were administered to two groups of ICR mice (ten male and ten female mice per group) for 3 months. During the experimental period, we observed that the mice fed the 30 kGy-irradiated Dakgalbi did not show any changes in appearance, behavior, mortality, body weight, organ weight, or food consumption compared to the control mice group. In addition, all biochemical parameters of these mice, including hematology profiles, erythrocyte counts, and serum biochemical values, remained in the normal range. The histopathological examinations of liver and kidney tissues showed no significant differences between the control group and the group fed the 30 kGy-irradiated Dakgalbi. These results indicate that Dakgalbi irradiated at 30 kGy did not cause any toxic effects in mice and therefore it can be considered as safe and hygienic space food.

본 연구에서는 닭갈비의 우주식품으로서 안전성을 확보하기 위하여 30 kGy 조사된 닭갈비를 ICR 마우스에 3개월간 섭취시킨 다음 안전성평가를 수행하였다. 비조사 시료 및 30 kGy 조사 닭갈비를 암수 마우스에 투여를 한 결과 시험기간 동안 시험물질에 의한 임상증상이나 폐사 동물이 나타나지 않았으며, 체중변화, 사료섭취량 및 주요 장기무게도 대조군과 차이를 보이지 않았다. 혈액학적 검사 및 혈청학적 검사 모두 정상적인 수치를 나타내었다. 병리조직학적 검사 역시 간 및 신장 모두 정상적인 구조를 유지하고 있었으며 염증, 괴사 등의 유의할만한 병적 변화도 관찰되지 않았다. 따라서 30 kGy로 감마선 조사된 닭갈비는 암수 마우스에 3개월간 섭취시켜도 본 시험조건에서는 독성이 없는 것으로 판명되었다.

Keywords

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