Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Prolyl Endopeptidase Inhibitory Activity of Two Styrylpyranones from Phellinus linteus

  • Yoon, Hye-Ryeon (Department of Applied Chemistry and Plant Metabolism Research Center, Kyung Hee University) ;
  • Han, Ah-Reum (Department of Applied Chemistry and Plant Metabolism Research Center, Kyung Hee University) ;
  • Paik, Young-Sook (Department of Applied Chemistry and Plant Metabolism Research Center, Kyung Hee University)
  • Received : 2013.01.02
  • Accepted : 2013.06.03
  • Published : 2013.09.30
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Abstract

Two styrylpyranones (1 and 2) were isolated from the $CH_2Cl_2$-soluble fraction of Phellinus linteus and their structures were established by extensive Nuclear magnetic resonance (NMR) spectral data as inoscavin E and C. Both compounds showed significant prolyl endopeptidase inhibitory activity with $IC_{50}$ values of $4.26{\pm}0.14$ and $4.08{\pm}0.04{\mu}M$ and $K_i$ values of $1.50{\pm}0.02$ and $1.43{\pm}0.03{\mu}M$, respectively. They also exhibited antioxidant capacities against the ABTS radical system with $EC_{50}$ values of $6.47{\pm}0.05$ and $7.64{\pm}0.06{\mu}M$, respectively.

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References

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