Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Effects of Curcuma longa $L_{INNE}$ Pharmacopuncture at $ST_{36}$ on Adjuvant Induced Arthritis in Rats

강황(薑黃)약침이 CFA로 유발된 류마티스성 관절염에 미치는 영향

  • Lee, Ook Jae (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Lee, Dong Geun (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Lee, Ju Hee (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Lee, Jung Hun (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Lee, Sang Hyun (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Park, Geun Hee (Department of Sasang Constitutional Medicine, College of Oriental Medicine, Dongshin University) ;
  • Shin, Jeong Cheol (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University)
  • 이욱재 (동신대학교 한의과대학 침구의학교실) ;
  • 이동근 (동신대학교 한의과대학 침구의학교실) ;
  • 이주희 (동신대학교 한의과대학 침구의학교실) ;
  • 이정훈 (동신대학교 한의과대학 침구의학교실) ;
  • 이상현 (동신대학교 한의과대학 침구의학교실) ;
  • 박근희 (동신대학교 한의과대학 사상체질의학교실) ;
  • 신정철 (동신대학교 한의과대학 침구의학교실)
  • Received : 2013.08.08
  • Accepted : 2013.08.26
  • Published : 2013.09.20
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Abstract

Objectives : The objective of this study was to investigate the effects of Curcuma longa $L_{INNE}$ pharmacopuncture at $ST_{36}$ on Complete Freund's Adjuvant(CFA)-induced arthritis in rats. Materials and methods : Arthritis was induced by injecting CFA subcutaneously into the left knee joint and paw, and Curcuma longa $L_{INNE}$ pharmacopuncture(CLL-A. $0.0343{\mu}g/kg$; CLL-B. $0.171{\mu}g/kg$; CLL-C. $0.343{\mu}g/kg$) was injected at $ST_{36}$ each other day for 5 times beginning on day 10 after the CFA injection. Paw edema, withdrawal response, hematological, serological and histological observation were assessed. Results : In paw edema volume all 3 groups(CLL-A, CLL-B, CLL-C) showed significant decrease compared to the CFA control group. In withdrawal response to reaction time and withdrawal response to force all 3 groups(CLL-A, CLL-B, CLL-C) showed significant increase compared to the CFA control group. In serum AST, group CLL-C showed significant decrease compared to the CFA control group. In histological observations, in all 3 groups, more normal chondrocytes were observed compared to the CFA control group and safranin O stain showed high positive reaction in the cartilage tissue close to the bone tissue. Conclusions : The results suggest that Curcuma longa $L_{INNE}$ Pharmacopuncture at $ST_{36}$ has a suppressing inflammation effect on Freund's adjuvant arthritis in rats.

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