Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities against Melanoma Cell Line

  • Kim, Hee Jin (Chemical Kinomics Research Center, Korea Institute of Science and Technology) ;
  • Oh, Chang-Hyun (Center for Biomaterials, Korea Institute of Science and Technology) ;
  • Yoo, Kyung Ho (Chemical Kinomics Research Center, Korea Institute of Science and Technology)
  • Received : 2013.04.15
  • Accepted : 2013.05.07
  • Published : 2013.08.20
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Abstract

A series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds 1a-c, k and 2b-d, f, g, j, l showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 2f possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with $IC_{50}$ value in nanomolar scale.

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References

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  1. ChemInform Abstract: Synthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities Against Melanoma Cell Line. vol.44, pp.51, 2013, https://doi.org/10.1002/chin.201351188