Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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DNA Topoisomerases I and II Inhibitory Activity and Cytotoxicity of Compounds from the Stems of Parthenocissus tricuspidata

  • Woo, Mi Hee (College of Pharmacy, Catholic University of Daegu) ;
  • Zhao, Bing Tian (College of Pharmacy, Catholic University of Daegu) ;
  • Tran, Manh Hung (College of Pharmacy, Catholic University of Daegu) ;
  • Jeong, Su Yang (College of Pharmacy, Catholic University of Daegu) ;
  • Ma, Eun Sook (College of Pharmacy, Catholic University of Daegu) ;
  • Min, Byung Sun (College of Pharmacy, Catholic University of Daegu)
  • Received : 2013.05.02
  • Accepted : 2013.06.18
  • Published : 2013.09.20
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Abstract

Activity-directed isolation of the methylene chloride fraction from the stems of Parthenocissus tricuspidata have led to the identification of two new compounds (1-2): 1-(2',3',5'-trihydroxyphenyl)-2-(4"-hydroxyphenyl)-ethane-1,2-(E)-epoxide (1, tricuspidatin A) and erythro-1-(3',5'-dihydroxyphenyl)-2-(4"-hydroxyphenyl)-ethane-1,2-diol (2, tricuspidatin B), together with four known compounds (3-6): ${\beta}$-sitosterol (3), nonacosan-1-ol (4), 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid hexacosyl ester (5) and betulinic acid (6). Their chemical structures were elucidated based on spectroscopic (IR, UV, MS, 1D and 2D NMR) and physicochemical analyses. Compounds 1 and 2 showed strong DNA topoisomerase II inhibitory activity at both concentrations of 20 and $100{\mu}M$. In addition, 3 exhibited strong cytotoxic activity against the HT-29 and HepG2 cancer cell lines, and 6 showed strong cytotoxicity against the HT-29 and MCF-7 ones.

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