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A Study on the Physical and Chemical Characteristics and Hazards Buthanethiol

Buthanethiol의 물리화학적 특성과 유해성 연구

  • Kim, Hyeon-Yeong (Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency)
  • 김현영 (한국산업안전보건공단 산업안전보건연구원)
  • Received : 2013.06.07
  • Accepted : 2013.08.19
  • Published : 2013.08.31

Abstract

Butanethiol is known as a typical odorant with hydrogen sulfide, methyl mercaptan, methyl sulfide, but on the physical and chemical properties and biological hazard assessment, including inhalation toxicity data are very scarce. Butanethiol as a colorless transparent liquid, and has physic-chemical characteristics with flash point as $-23^{\circ}C$ and strong fire risk, boiling point $84-85^{\circ}C$, vapor pressure 80.71 mmHg ($25^{\circ}C$), freezing point $-140.14^{\circ}C$. From whole body exposure with SD rats, the $LC_{50}$ is above 2,500 ppm (9.22mg/L), and then it is classified as the acute toxic chemical (inhalation) category 4 according to the governmental notification No. 2012-14.

Butanethiol은 황화수소, 메틸메르캅탄, 황화메틸 등과 함께 유해성이 높으며 대표적인 악취물질로 알려져 있으나 노출 농도별 생체에 미치는 영향 등 유해성 평가 자료가 매우 부족하여 실험동물을 이용 흡입독성 연구를 통하여 유해농도와 사람에 미치는 영향을 예측하고자 연구하였다. Butanethiol은 무색 투명액체로, 인화점 $-23^{\circ}C$로 화재위험성이 강한물질로 끓는점 $84-85^{\circ}C$, 증기압($25^{\circ}C$) 80.71 mmHg, 어는점 $-140.14^{\circ}C$의 특성을 가지고 있다. 실험동물인 SD rats와 전신흡입노출 챔버를 이용 반수치사농도를 시험한 결과 $LC_{50}$은 2,500 ppm (9.22mg/L)이상으로 이는 고용부 고시 제2012-14호[11]의 유해물질 분류기준 급성독성물질 구분 4 (10${\leq}20$ mg/L) 이상의 물질에 해당되었다. 또한 0, 25, 100, 400 ppm, 일일 6시간, 주 5일, 13주 반복 노출한 결과에서는 25 및 400 ppm군에서 체중의 유의성(p<0.01., 0.001) 있는 저하를 포함 4사료섭취량 변화, 안 자극, 수컷군의 운동성변화, 혈액 및 혈액생화학적 병변이 있었으며, 장기중량에서도 수컷의 경우 25, 100, 400 ppm군과 암컷의 400 ppm군에서 신장, 간장, 흉선, 폐장 등에서 유의성 (p<0.05) 있는 변화가 있어 무유해영향농도 (NOAEL)는 암 수 모두 25 ppm (0.092 mg/L) 이하로 평가되었다.

Keywords

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