한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제30권4호
  • /
  • Pages.315-319
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  • 2013
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

개에서 발생한 피부 상피친화성 T-세포 림프종: Lomustine 및 Gemcitabine에 대한 임상적 반응

Cutaneous Epitheliotropic T-Cell Lymphoma in a Dog: Clinical Responses to Lomustine and Gemcitabine

  • 강병택 (충북대학교 수의과대학) ;
  • 김대영 (미국 미주리 수의과대학) ;
  • 강지훈 (충북대학교 수의과대학) ;
  • 장동우 (충북대학교 수의과대학) ;
  • 정동인 (경상대학교 생명과학연구원) ;
  • 조규완 (경상대학교 생명과학연구원) ;
  • 양만표 (충북대학교 수의과대학)
  • Kang, Byeong-Teck (Veterinary Teaching Hospital, College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Dae Young (Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri) ;
  • Kang, Ji-Houn (Veterinary Teaching Hospital, College of Veterinary Medicine, Chungbuk National University) ;
  • Chang, Dong-Woo (Veterinary Teaching Hospital, College of Veterinary Medicine, Chungbuk National University) ;
  • Jung, Dong-In (Research Institute of Life Sciences, Gyeongsang National University) ;
  • Cho, Kyu-Woan (Research Institute of Life Sciences, Gyeongsang National University) ;
  • Yang, Mhan-Pyo (Veterinary Teaching Hospital, College of Veterinary Medicine, Chungbuk National University)
  • 심사 : 2013.08.06
  • 발행 : 2013.08.31
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초록

5년령의 중성화된 암컷 말티즈가 1개월 동안 지속된 전신적 발적, 탈모 및 소양감으로 내원하였다. 피부조직구증으로 진단되어 면역억제치료를 1개월 간 지속하였지만 다발성의 발적된 반 및 판 병변들이 새롭게 발생하였다. 피부병변에 대한 압박도말검사에서 림프종을 지시하는 원형세포들이 관찰되었다. 조직학적 검사에서는 종양세포들의 외피 및 부속구조물에 대한 친화성이 나타났다. 면역염색결과 종양세포들은 CD3에 대하여 양성, CD79a에 대해서는 음성반응을 나타내어 피부 상피친화성 T-세포 림프종으로 확진하였다. $70mg/m^2$의 lomustine을 2-3주 간격으로 총 2회 투여하였으며 부분적인 치료반응이 관찰되었다. 피부병변의 악화와 lomustine의 이용제한으로 gemcitabine ($500mg/m^2$, 1주일당 1회 30분간 혈관주입)을 이용한 화학치료를 시작하였다. 총 3회 치료가 실시되었으나 질병의 진행을 억제하지 못하였으며, 최초 lomustine 치료 69일 후 안락사 되었다.

A 5-year-old, spayed female Maltese dog presented with generalized multifocal pruritic erythema and alopecia for a month. Initial skin biopsy suggested cutaneious histiocytosis. The dog had been treated with the immunosuppressive therapy for a month, but multifocal erythematous patches and plaques were newly observed. Direct imprint smear of cutaneous lesions suggested a lymphoma and rebiopsy was performed. Microscopic examination demonstrated a round cell tumor with epitheliotrophism to the epidermis and adnexal structures. The neoplastic round cells were strongly positive for CD3 yet negative for CD79a, indicting the tumor was cutaneous epitheliotropic T-cell lymphoma. After 2 cycles of oral administration of lomustine ($70mg/m^2$, once every 2-3 weeks), only partial response was observed. Alternative chemotherapy with gemcitabine ($500mg/m^2$, 30-minute IV infusion, once every week) was initiated. A total 3 cycles of gemcitabine failed to control the progression of disease, and the dog was euthanized on Day 69 after the 1st lomustine treatment.

키워드

참고문헌

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