References
- Aybar, M. J., Snchez Riera, A. N., Grau, A. and Snchez, S. S. : Hypoglycemic effect of the water extract of Smallanthus sonchifolius (yacon) leaves in normal and diabetic rats. J. Ethnopharm. 74, 125 (2001). https://doi.org/10.1016/S0378-8741(00)00351-2
- Habib, N. C., Honor, S. M., Genta, S. B. and Snchez, S. S. : Hypolipidemic effect of Smallanthus sonchifolius (yacon) roots on diabetic rats: Biochemical approach. Chem. Biol. Interact. 194, 31 (2011). https://doi.org/10.1016/j.cbi.2011.08.009
- Yan, X., Suzuki, M., Ohnishi-Kameyama, M., Sada, Y., Nakanishi, T. and Nagata, T. : Extraction and identification of antioxidants in roots of yacon (Smallanthus sonchifolius). J. Agric. Food Chem. 47, 4711 (1999). https://doi.org/10.1021/jf981305o
- Simonovska, B., Vovk, I., Andrenek, S., Valentov, K. and Ulrichov, J. : Investigation of phenolic acids in yacon (Smallanthus sonchifolius) leaves and tubers. J. Chromatography A 1016, 89 (2003). https://doi.org/10.1016/S0021-9673(03)01183-X
- Goto, K., Fukai, K., Hikida, J., Nanjo, F. and Hara, Y. : Isolation and structural analysis of oligosaccharides from yacon (Polymnia sonchifolia). Biosci. Biotechnol. Biochem. 59, 2346 (1995). https://doi.org/10.1271/bbb.59.2346
- Park, J. S., Hwang, S. Y., Hwang, B. Y. and Han, K. : The spermatogenic effect of 50% ethanol extracts of Yacon and Its ameliorative effect against 2,3,7,8-tetrachlorodibenzo-p-dioxin induced testicular toxicity in the rat. Nat. Prod. Sci. 14, 73 (2008).
- Park, J. S., Hwang, S. Y. and Han, K. : The spermatogenic effect of 50% ethanol extracts of Yacon in healthy male volunteers. YakhakHoeji 53, 250 (2009).
- Hiipakka, R. A., Zhang, H. Z., Dai, W., Dai, Q. and Liao, S. : Structure-activity relationships for inhibition of human 5alphareductases by polyphenols. Biochem. Pharmacol. 63, 1165 (2002). https://doi.org/10.1016/S0006-2952(02)00848-1
-
Sun, J., Xiang, H., Yang, L. L. and Chen, J. B. : A review on steroidal 5
$\alpha$ -reductase inhibitors for treatment of benign prostatic hyperplasia. Curr. Med. Chem. 18, 3576 (2011). https://doi.org/10.2174/092986711796642517 -
Pumthong, G., Asawanonda, P., Varothai, S., Jariyasethavong, V., Triwongwaranat, D., Suthipinittharm, P., Ingkaninan, K., Leelapornpisit, P. and Waranuch, N. : Curcuma aeruginosa, a novel botanically derived 5
$\alpha$ -reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study. J. Dermatolog. Treat. 23, 385 (2012). https://doi.org/10.3109/09546634.2011.568470 - Bach, D., Schmitt, M. and Ebeling, L. : Phytopharmaceutical and synthetic agents in the treatment of benign prostatic hyperplasia (BPH). Phytomedicine. 3, 309 (1997). https://doi.org/10.1016/S0944-7113(97)80001-3
- Park, W. S., Son, E. D., Nam, G. W., Kim, S. H., Noh, M. S., Lee, B. G., Jang, I. S., Kim, S. E., Lee, J. J. and Lee, C. H. : Torilin from Torilis japonica, as a new inhibitor of testosterone 5 alpha-reductase. Planta Med. 69, 459 (2003). https://doi.org/10.1055/s-2003-39717
-
Choi, S. M., Kim, C. D., Lee, M. H., Choi, Y. H., Rang, M. J., Ahn, H. J. and Yun, Y. P. : Screening of 5
$\alpha$ -reductase inhibition and comedolytic effects from natural products. Yakkak Hoeji 43, 342 (1999). - Lu, X., Liu, W. and Luo, C. : Apoptotic effect of coix polysaccharides on A549 lung cancer cells in vitro. Zhongguo Fei Ai Za Zhi. 15, 624 (2012).
- Chen, H. J., Hsu, H. Y. and Chiang, W. : Allergic immuneregulatory effects of adlay bran on an OVA-immunized mice allergic model. Food Chem Toxicol. 50, 3808 (2012). https://doi.org/10.1016/j.fct.2012.07.011
- Chung, C. P., Hsia, S. M., Lee, M. Y., Chen, H. J., Cheng, F., Chan, L. C., Kuo, Y. H., Lin, Y. L. and Chiang, W. : Gastroprotective activities of adlay (Coix lachryma -jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers. J. Agric. Food Chem. 59, 6025 (2011). https://doi.org/10.1021/jf2009556
- Chen, Q. X., Miao, J. K., Li, C., Li, X. W., Wu, X. M. and Zhang, X. P. : Anticonvulsant activity of acute and chronic treatment with a-asarone from Acorus gramineus in seizure models. Biol. Pharm. Bull. 36, 23 (2013).
-
Liu, J., Kurashiki, K., Shimizu, K. and Kondo, R. : Structureactivity relationship for inhibition of 5
$\alpha$ -reductase by triterpenoids isolated from Ganoderma lucidum. Bioorg. Med. Chem. 14, 8654 (2006). https://doi.org/10.1016/j.bmc.2006.08.018 - Lowry, O. H., Rosbrough, N. J., Farr, A. L. and Randall, R. J. : Protein measurement with the Folin Phenol reagent. J. Biol. Chem. 193, 265 (1951).
-
Matsuda, H., Sato, N., Yamazaki, M., Naruto, S. and Kubo, M. : Testosterone 5
$\alpha$ -reductase inhibitory active constituents from Anemarrhenae Rhizoma. Biol. Pharm. Bull. 24, 586 (2001). https://doi.org/10.1248/bpb.24.586 -
Kumar, T., Chaiyasut, C., Rungseevijitprapa W. and Suttajit, M. : Screening of steroid 5
$\alpha$ -reductase inhibitory activity and total phenolic content of Thai plants. J. Med. Plants Res. 5, 1265 (2011). - Ranall, V. A. : Role of 5alpha-reductase in health and disease. Baillieres Clin. Endoclinol. Metab. 8, 405 (1994). https://doi.org/10.1016/S0950-351X(05)80259-9
- Meinhardt, U. and Mullis, P. E. : The essential role of the aromatase/p450arom. Semin. Reprod. Med. 20, 277 (2002). https://doi.org/10.1055/s-2002-35374
- Wood, A. W., Swinney, D. C., Thomas, P. E., Ryan, D. E., Hall, P. F., Levin, W. and Garland, W. A. : Mechanism of androstenedione formation from testosterone and epitestosterone catalyzed by purified cytochrome P-450b. J. Biol. Chem. 17322 (1988).