Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Gnathostoma spinigerum Infection in the Upper Lip of a Korean Woman: An Autochthonous Case in Korea

  • Kim, Jae Hee (Department of Plastic and Reconstructive Surgery, Bundang Jesaeng General Hospital) ;
  • Lim, Hyemi (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine) ;
  • Hwang, Young-Sang (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine) ;
  • Kim, Tae Yeon (Department of Plastic and Reconstructive Surgery, Bundang Jesaeng General Hospital) ;
  • Han, Eun Mee (Department of Pathology, Bundang Jesaeng General Hospital) ;
  • Shin, Eun-Hee (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine) ;
  • Chai, Jong-Yil (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
  • Received : 2013.04.05
  • Accepted : 2013.05.29
  • Published : 2013.06.30
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Abstract

Autochthonous human gnathostomiasis had never been reported in the Republic of Korea. We report here a case of Gnathostoma spinigerum infection in a 32-year-old Korean woman, presumed to have been infected via an indigenous route. The patient had experienced a painful migratory swelling near the left nasolabial fold area of the face for a year, with movement of the swelling to the mucosal area of the upper lip 2 weeks before surgical removal of the lesion. Histopathological examinations of the extracted tissue revealed inflammation with heavy eosinophilic infiltrations and sections of a nematode suggestive of a Gnathostoma sp. larva. The larva characteristically revealed about 25 intestinal cells with multiple (3-6) nuclei in each intestinal cell consistent with the 3rd-stage larva of G. spinigerum. The patient did not have any special history of travel abroad except a recent trip, 4 months before surgery, to China where she ate only cooked food. The patient is the first recorded autochthonous case of G. spinigerum infection in Korea.

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References

  1. Miyazaki I. An Illustrated Book of Helminthic Zoonoses. Fukuoka, Japan. International Medical Foundation of Japan. 1991, p 368-409.
  2. Katchanov J, Sawanyawisuth K, Chotmongkol V, Nawa Y. Neurognathostomiasis, a neglected parasitosis of the central nervous system. Emerg Infect Dis 2011; 17: 1174-1180. https://doi.org/10.3201/eid1707.101433
  3. Rusnak JM, Lucey DR. Clinical gnathostomiasis: case report and review of the English-language literature. Clin Infect Dis 1993; 16: 33-50. https://doi.org/10.1093/clinids/16.1.33
  4. Dekumyoy P, Yoonuan T, Waikagul J. Gnathostoma. In Liu D, ed, Molecular Detection of Human Parasitic Pathogens. Boca Raton, London, New York. CRC Press, Taylor-Francis Group. 2013, p. 563-570.
  5. Nomura Y, Nagakura K, Kagei N, Tsutsumi Y, Araki K, Sugawara M. Gnathostomiasis possibly caused by Gnathostoma malaysiae. Tokai J Exp Clin Med 2000; 25: 1-6.
  6. Nawa Y. Historical review and current status of gnathostomiasis in Asia. Southeast Asian J Trop Med Public Health 1991; 22 (suppl.): 217-219.
  7. Herman JS, Chiodini PL. Gnathostomiasis, another emerging imported disease. Clin Microbiol Rev 2009; 22: 484-492. https://doi.org/10.1128/CMR.00003-09
  8. Herman JS, Wall EC, van Tulleken C, Godfrey-Faussett P, Bailey RL, Chiodini PL. Gnathostomiasis acquired by British tourists in Botswana. Emerg Infect Dis 2009; 15: 594-597. https://doi.org/10.3201/1504.081646
  9. Kim YK. A study on Gnathostoma (1) An investigation into the geographical distribution of larvae on the second-third stage in Gyeongsang Nam Do. Bull Pusan Nat Univ (Natural Science, Korea) 1973; 15: 111-116 (in Korean).
  10. Han ET, Lee JH, Choi SY, Park JH, Shin EH, Chai JY. Surface ultrastructure of the advanced third-stage larvae of Gnathostoma nipponicum. J Parasitol 2003; 89: 1245-1248. https://doi.org/10.1645/GE-3232RN
  11. Woo HC, Oh HS, Cho SH, Na BK, Sohn WM. The Jeju weasel, Mustela siblica quelpartis, a new definitive host for Gnathostoma nipponicum Yamaguti, 1941. Korean J Parasitol 2011; 49: 317-321. https://doi.org/10.3347/kjp.2011.49.3.317
  12. Woo HC, Oh HS, Cho SH, Na BK, Sohn WM. Discovery of larval Gnathostoma nipponicum in frogs and snakes from Jeju-do (Province), Republic of Korea. Korean J Parasitol 2011; 49: 445-448. https://doi.org/10.3347/kjp.2011.49.4.445
  13. Sohn WM, Lee SH. The first discovery of larval Gnathostoma hispidum (Nematoda: Gnathostomidae) from a snak host, Agkistrodon brevicaudus. Korean J Parasitol 1998; 36: 81-89. https://doi.org/10.3347/kjp.1998.36.2.81
  14. Lee SH, Hong ST, Chai JY. Description of a male Gnathostoma spinigerum recovered from a Thai woman with meningoencephalitis. Korean J Parasitol 1988; 26: 33-38. https://doi.org/10.3347/kjp.1988.26.1.33
  15. Lee SD, Lee HJ, Kim JW. A case of gnathostomiasis. Korean J Dermatol 2001; 39: 1427-1429.
  16. Kim HS, Lee JJ, Joo M, Chang SH, Chi JG, Chai JY. Gnathostoma hispidum infection in a Korean man returning from China. Korean J Parasitol 2010; 48: 259-261. https://doi.org/10.3347/kjp.2010.48.3.259
  17. Yang JH, Kim M, Kim ES, Na BK, Yu SY, Kwak HW. Imported intraocular gnathostomiasis with subretinal tracks confirmed by western blot assay. Korean J Parasitol 2012; 50: 73-78. https://doi.org/10.3347/kjp.2012.50.1.73
  18. Chai JY, Han ET, Shin EH, Park JH, Chu JP, Hirota M, Nakamura-Uchiyama F, Nawa Y. An outbreak of gnathostomiasis among Korean emigrants in Myanmar. Am J Trop Med Hyg 2003; 69: 67-73.
  19. Akahane H, Sano M, Mako T. Morphological difference in cross sections of the advanced third-stage larvae of Gnathostoma spinigerum, G. hispidum and G. doloresi. Jpn J Parasitol 1986; 35: 465-467.
  20. Ando K, Hatsushika R, Akahane H, Matsuoka H, Taylor D, Miura K, Chinzei Y. Gnathostoma nipponicum infection in the past human cases in Japan. Jpn J Parasitol 1991; 40: 184-186.
  21. Daengsvang S. Human gnathostomiasis in Siam with reference to the method of prevention. J Parasitol 1949; 35: 116-121. https://doi.org/10.2307/3273112
  22. Prommas C, Daengsvang S. Nine cases of human gnathostomiasis. Indian Med Gazette 1934; 69: 207-210.
  23. Srisawai P, Jongwutiwes S, Lingual gnathostomiasis: a case report. J Med Assoc Thai 1988; 71: 285-288.
  24. Cuchavaree A, Supiyaphun P, Sitticharoenchai P, Suphanakorn S. A case of aural gnathostomiasis. Auris Nasus Larynx 1985; 12: 163-167. https://doi.org/10.1016/S0385-8146(85)80015-8
  25. Transurat P. Gnathostomiasis. J Med Assoc Thai 1955; 38: 25-32 (in Thai).

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