Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Cognitive Impairment and Decreased Quality of Life in Elderly Patients with Subsyndromal Depression

노인 아증후군적 우울증 환자의 인지기능 및 삶의 질 저하

  • Ryu, Jae Sung (Department of Psychiatry, Jeju National University Hospital, School of Medicine, Jeju National University) ;
  • Kim, Moon Doo (Department of Psychiatry, Jeju National University Hospital, School of Medicine, Jeju National University) ;
  • Lee, Chang In (Department of Psychiatry, Jeju National University Hospital, School of Medicine, Jeju National University) ;
  • Park, Joon Hyuk (Department of Psychiatry, Jeju National University Hospital, School of Medicine, Jeju National University)
  • 류재성 (제주대학교 의학전문대학원 제주대학교병원 정신건강의학교실) ;
  • 김문두 (제주대학교 의학전문대학원 제주대학교병원 정신건강의학교실) ;
  • 이창인 (제주대학교 의학전문대학원 제주대학교병원 정신건강의학교실) ;
  • 박준혁 (제주대학교 의학전문대학원 제주대학교병원 정신건강의학교실)
  • Received : 2013.03.25
  • Accepted : 2013.04.22
  • Published : 2013.05.31
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Abstract

Objectives Non-major depression with fewer symptoms than required for a Diagnostic and Statistical Manual of Mental Disorders-4th edition diagnosis of major depressive disorder (MDD) has consistently been found to be associated with functional impairment. In this study, we aim to estimate the cognitive impairment and the quality of life in elderly patients with subsyndromal depression (SSD) compared with non-depressive elderly (NDE). Methods The Korean version of Mini International Neuropsychiatric Interview was administered to 194 outpatients with depression and 108 normal controls. SSD is defined as having five or more current depressive symptoms with core depressive symptoms (depressive mood or loss of interest or pleasure) during more than half a day and more than seven days over two weeks. Depression was evaluated by the Korean form of Geriatric Depression Scale of a 15-item short version. Global cognition was assessed by Mini-Mental State Examination in the Korean version of CERAD assessment packet (MMSE-KC). Subjective cognitive impairment was assessed by the Subjective Memory Complaint Questionnaire. Quality of life was evaluated by the Korean Version of Short-Form 36-Item Health Survey. Results The mean score of the MMSE-KC in the SSD group was lower than that in the NDE group with adjustment for age, gender, and education [F = 4.270, p = 0.04, analysis of covariance (ANCOVA)]. If we defined those having Z-score of MMSE-KC < -1.5 as a high risk group of cognitive impairment, the odds ratio for the high risk group of cognitive impairment was 1.86 [95% confidence intervals (CI) 1.04-3.34] in SSD and 7.57 (95% CI 3.50-16.40) in MDD compared to NDE. The scores of physical component summary (F = 9.274, p = 0.003, ANCOVA) and mental component summary (F = 53.166, p < 0.001, ANCOVA) in the SSD group were lower than those in the NDE group with adjustment for age, gender, and education. Conclusions The subjects with SSD, as well as those with MDD, showed impairment of global cognition and also experienced low quality of life in both physical and mental aspects, compared to the NDE group.

Keywords

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