Hanyang Medical Reviews (한양메디칼리뷰)

Hanyang University College of Medicine (한양대학교 의과대학)
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Interleukin-17 in the Inflammatory Bowel Disease

Interleukin-17의 발현이 염증성장질환의 발생과 진행에 끼치는 영향

  • Lee, Cho-Rong (School of Life Sciences, Gwangju Institute of Science and Technology) ;
  • Park, Sung-Gyoo (School of Life Sciences, Gwangju Institute of Science and Technology)
  • 이초롱 (광주과학기술원 생명과학부) ;
  • 박성규 (광주과학기술원 생명과학부)
  • Received : 2012.11.15
  • Accepted : 2013.01.10
  • Published : 2013.02.28
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Abstract

Inflammatory bowel diseases(IBD), including Crohn's disease and ulcerative colitis, are chronic inflammatory states of the intestinal tract. While the exact mechanisms inducing chronic inflammation are still unclear, it is hypothesized that the inflammation is caused in part by an inappropriate immune response to the intestinal microflora. Although inflammatory diseases are not directly linked to patient survival, symptoms of these diseases significantly decrease quality of life. The incidence rate is higher in western people than eastern people, but the incidence rate of IBD in eastern people, including Korean, is increasing. Recently, it has been reported that IL-17 is an important factor that appears to be involved in IBD induction and progression. This report reviews many recent papers reporting the relationship between IBD and IL-17, which may provide an understanding leading to new means of prevention and treatment for IBD.

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Acknowledgement

This work wassupported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A111838) and by the BioimagingResearchCenter at GIST.