Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins

  • Hong, Su Hee (Department of Biochemistry, College of Medicine, Hallym University) ;
  • Heo, Jee-In (Department of Biochemistry, College of Medicine, Hallym University) ;
  • Kim, Jeong-Hyeon (Department of Biochemistry, College of Medicine, Hallym University) ;
  • Kwon, Sang-Oh (S&D Co., Ltd.) ;
  • Yeo, Kyung-Mok (S&D Co., Ltd.) ;
  • Bakowska-Barczak, Anna M. (Department of Agricultural, Food and Nutritional Science, University of Alberta) ;
  • Kolodziejczyk, Paul (Department of Fruit, Vegetable and Cereal Technology, Wroclaw University of Environmental and Life Sciences) ;
  • Ryu, Ok-Hyun (Department of Internal Medicine, Chuncheon Sacred Heart Hospital/Hallym University Medical Center) ;
  • Choi, Moon-Ki (Department of Internal Medicine, Chuncheon Sacred Heart Hospital/Hallym University Medical Center) ;
  • Kang, Young-Hee (Department of Food and Nutrition, College of Natural Sciences, College of Medicine, Hallym University) ;
  • Lim, Soon Sung (Institute of Natural Medicine, College of Medicine, Hallym University) ;
  • Suh, Hong-Won (Institute of Natural Medicine, College of Medicine, Hallym University) ;
  • Huh, Sung-Oh (Institute of Natural Medicine, College of Medicine, Hallym University) ;
  • Lee, Jae-Yong (Department of Biochemistry, College of Medicine, Hallym University)
  • Received : 2013.02.07
  • Accepted : 2013.06.18
  • Published : 2013.07.31
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Abstract

Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.

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References

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