KSBB Journal

  • 제28권3호
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  • Pages.196-201
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  • 2013
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  • 1225-7117(pISSN)
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  • 2288-8268(eISSN)
한국생물공학회 (The Korean Society for Biotechnology and Bioengineering)
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수용성 누에 실샘 가수분해물의 미백 및 항노화 효과

Whitening and Anti-aging Activities of Soluble Silkworm Gland Hydrolysate

  • 정지혜 (차의과학대학교 생명과학대학 바이오공학과) ;
  • 황정욱 (차의과학대학교 생명과학대학 바이오공학과) ;
  • 김호진 (차의과학대학교 생명과학대학 바이오공학과) ;
  • 차현명 (인하대학교 공과대학 생물공학과) ;
  • 김동일 (인하대학교 공과대학 생물공학과) ;
  • 최용수 (차의과학대학교 생명과학대학 바이오공학과)
  • 투고 : 2013.04.30
  • 심사 : 2013.06.25
  • 발행 : 2013.06.27
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초록

Silkworm-derived silk materials which contain 45 to 55% protein (18 amino acids, including 8 essential amino acids) have free radical-scavenging activities. In the present study, we investigated the whitening and anti-aging effects of silkworm gland under various conditions with B16F1 melanoma cells and human dermal fibroblasts. To evaluate the toxicity of soluble gland hydrolysate (SGH), mouse-derived B16F1 melanoma cells were treated with 0.2~5 mg/mL, cytotoxicity was not observed at all concentrations. The tyrosinase and elastase activities were significantly decreased as dosage levels of SGH increased. In addition, cell death was decreased by treated with SGH and antioxidative activity was the most effective in the SGH treatment. These findings suggest that SGH may be used as a potential functional biomaterial in having the skin whitening effect and anti-aging activity by inhibition of tyrosinase and elastase activities.

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참고문헌

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피인용 문헌

  1. Whitening Effect of Storage Protein 2 from Silkworm Hemolymph vol.05, pp.09, 2014, https://doi.org/10.4236/abb.2014.59089