생명과학회지 (Journal of Life Science)

  • 제23권7호
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  • Pages.947-954
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  • 2013
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
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Wnt/β-catenin 신호를 조절하는 인산화 효소

Protein Kinases Involved in the Regulation of Wnt/β-catenin Signaling

  • 신은영 (한국기초과학지원연구원 생명과학연구부) ;
  • 박창균 (한국기초과학지원연구원 생명과학연구부) ;
  • 홍연희 (한국기초과학지원연구원 생명과학연구부) ;
  • 김건화 (한국기초과학지원연구원 생명과학연구부)
  • Shin, Eun-Young (Division of Life Science, Korea Basic Science Institute (KBSI)) ;
  • Park, Edmond Changkyun (Division of Life Science, Korea Basic Science Institute (KBSI)) ;
  • Hong, Yeonhee (Division of Life Science, Korea Basic Science Institute (KBSI)) ;
  • Kim, Gun-Hwa (Division of Life Science, Korea Basic Science Institute (KBSI))
  • 투고 : 2013.06.29
  • 심사 : 2013.07.08
  • 발행 : 2013.07.30
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초록

Wnt/${\beta}$-catenin 신호는 세포의 운명 결정, 증식, 분화 등을 조절하는 척추 동물 배아 발생과 성체의 항상성 유지에 필수적인 세포신호전달경로이다. 이러한 Wnt/${\beta}$-catenin의 비정상적인 조절에 의해 선천적 기형, 암, 대사질환 등을 비롯한 다양한 질병이 유발된다. 이를 바탕으로 최근 Wnt/${\beta}$-catenin 신호의 조절을 통한 암을 비롯한 질병의 치료를 위한 연구가 활발히 진행되고 있다. 따라서 Wnt/${\beta}$-catenin 신호를 조절하는 인자의 발굴 및 자세한 작용 기전에 대한 연구가 절실히 필요하다. 본 총설에서는 최근 새롭게 알려진 Wnt/${\beta}$-catenin 신호 조절 기작에 대해 설명하고, 현재까지 알려진 Wnt/${\beta}$조절하는 인산화 효소(kinase)의 종류와 작용 기전과 새로운 약물 타겟으로 전망을 알아 보고자 한다.

The Wnt/${\beta}$-catenin signaling pathway is an evolutionarily conserved signaling network that is critical for embryonic development and adult tissue maintenance. In addition, aberrant activation of Wnt/${\beta}$-catenin signaling is implicated in the formation of various human diseases, including cancers. Thus, study of the underlying molecular mechanism of Wnt/${\beta}$-catenin signaling regulation is important to understand and treat diseases. Inhibition of aberrant Wnt pathway activity in cancer cell lines efficiently blocks their growth, highlighting the great potential of therapeutics designed to achieve this in cancer patients. Recently, protein kinases have emerged as key regulating components of Wnt/${\beta}$-catenin signaling. In this review, we provide the most recent information on Wnt/${\beta}$-catenin signaling, describe protein kinases involved in Wnt/${\beta}$-catenin signaling, and discuss their potential as drug targets.

키워드

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