DOI QR코드

DOI QR Code

Expression and Role of ICAM-1 in the Occurrence and Development of Hepatocellular Carcinoma

  • Zhu, Xi-Wen (Department of Hepatobiliary Surgery, the Second Affiliated Hospital, Chongqing Medical University) ;
  • Gong, Jian-Ping (Department of Hepatobiliary Surgery, the Second Affiliated Hospital, Chongqing Medical University)
  • 발행 : 2013.03.30

초록

Intercellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin superfamily, its main function being to participate in recognition and adhesion between cells. ICAM-1 is considered closely related to occurrence, development, metastasis and invasion process of hepatocellular carcinoma (HCC). A variety of inflammatory cytokines and stimulus affect its expression through the nuclear factor-kappa B (NF-${\kappa}B$) signal transduction pathway. In the initial stage of inflammation, hepatocirrhosis and tumor development, ICAM-1 is expressed differently, and has varied effects on different cells to promote occurrence of malignancy and metastasis. ICAM-1 has diagnostic significance for AFP-negative or suspected HCC, and may be a prognositic significance. It is thus widely used in studies as a biomarker which reflects cancer cells metastasis as well as curative effect of drugs. Many new treatments of HCC may be based on the effects of ICAM-1 on different levels of function.

키워드

참고문헌

  1. Bernier AJ, Zhang J, Lillehoj E, et al (2011). Non-cysteine linked MUC1 cytoplasmic dimmers are required for Src recruitment and ICAM-1 binding induced cell invasion. Mol Cancer, 10, 93. https://doi.org/10.1186/1476-4598-10-93
  2. Connelly L, Barham W, Onishko HM, et al (2011). NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis mode. Breast cancer Res, 13, R83. https://doi.org/10.1186/bcr2935
  3. Dustin ML, Rothlein R, Bhan AK, et al (2011). Induction by IL 1 and interferon-$\gamma$: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol, 186, 5024-33.
  4. Hayes SH, Seigel GM (2009). Immunoreactivity of ICAM-1 in human tumors, metastases and normal tissues. Int J Clin Expe Pathol, 2, 553-60.
  5. Jung CW, Song TJ, Lee KO, et al (2012). Characterization of hepatocellular carcinoma cell lines based on cell adhesion molecules. Int J Mol Med, 29, 1158-64.
  6. Kim EJ, Choi MR, Park H, et al (2011). Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB/c mice. Breast Cancer Res, 13, R78. https://doi.org/10.1186/bcr2927
  7. Li L, Zeng J, Gao Y, et al (2010). Targeting silibinin in the antiproliferative pathway. Expert Opin Investig Drugs, 19, 243-55. https://doi.org/10.1517/13543780903533631
  8. Matsuoka S, Matsumura H, Arakawa Y, et al (2009). Expression of intercellular adhesion molecule-1 in the livers of rats treated with diethylnitrosamine. J Clin Biochem Nutr, 45, 137-43. https://doi.org/10.3164/jcbn.08-247
  9. Moon DO, Choi YH, Moon SK, et al (2011). Gossypol decreases tumor necrosis factor-$\alpha$-induced intercellular adhesion molecule-1 expression via suppression of NF-${\kappa}B$ activity. Food Chem Toxicol, 49, 999-1005. https://doi.org/10.1016/j.fct.2011.01.006
  10. Mueller L, Seggern LV, Schumacher J, et al (2010). TNF-alpha similarly induces IL-6 and MCP-1 in fibroblasts from colorectal liver metastases and normal liver fibroblasts. Biochem Biophys Res Commun, 397, 586-591. https://doi.org/10.1016/j.bbrc.2010.05.163
  11. Naschberger E, Schellerer VS, Rau TT, et al (2011). Isolation of endothelial cells from human tumors. Methods Mol Biol, 731, 209-18. https://doi.org/10.1007/978-1-61779-080-5_18
  12. Porta C, Riboldi E, Sica A, et al (2011). Mechanisms linking pathogens-associated inflammation and cancer. Cancer Lett, 305, 250-62. https://doi.org/10.1016/j.canlet.2010.10.012
  13. Prasad RC, Wang XL, Law BK, et al (2009). Identification of genes, including the gene encoding p27Kip1, regulated by serine 276 phosphorylation of the p65 subunit of NF-kappaB. Cancer Lett, 275, 139-49. https://doi.org/10.1016/j.canlet.2008.10.007
  14. Rizk NM, Derbala MF (2012). Genetic polymorphisms of ICAM 1 and IL28 as predictors of liver fibrosis severity and viral clearance in hepatitis C genotype 4. Clin Res Hepatol Gastroenterol, 5, S2210-7401(12)00259-8.
  15. Shetty S, Weston CJ, Oo YH, et al (2011). Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium. J Immunol, 186, 4147-55. https://doi.org/10.4049/jimmunol.1002961
  16. Shi C, Velazquez P, Hohl TM, et al (2010). Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. J Immunol, 184, 6266-74. https://doi.org/10.4049/jimmunol.0904160
  17. Song Z, Jin R, Yu S, et al (2011). CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury. PLoS One, 6, e23239. https://doi.org/10.1371/journal.pone.0023239
  18. Wang HT, Lee HI, Guo JH, et al (2012). Calreticulin and enhances the antitumor effects of immunotherapy by upregulating the endothelial expression of adhesion molecules. Int J Cancer, 130, 2892-902. https://doi.org/10.1002/ijc.26339
  19. Wong R, Chen X, Wang T, et al (2012). Visualizing and quantifying acute inflammation using ICAM-1 specific nanoparticles and MRI quantitative susceptibility mapping. Ann Biomed Eng, 40, 1328-38. https://doi.org/10.1007/s10439-011-0482-3
  20. Yin JQ, Wen L, Wu LC, et al (2013).The glycogen synthase kinase-3$\beta$/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. Toxicol Lett, 218, 129-36. https://doi.org/10.1016/j.toxlet.2012.11.006
  21. Zhang S, Liu S, Yu N, et al (2011). RNA released from necrotic keratinocytes upregulates intercellular adhesion molecule-1 expression in melanocytes. Arch Dermatol Res, 303, 771-6. https://doi.org/10.1007/s00403-011-1170-8

피인용 문헌

  1. STAT3 Target Genes Relevant to Human Cancers vol.6, pp.2, 2014, https://doi.org/10.3390/cancers6020897
  2. Martius) in Human SW-480 Colon Cancer Cells vol.66, pp.8, 2014, https://doi.org/10.1080/01635581.2014.956252
  3. FRET Based Quantification and Screening Technology Platform for the Interactions of Leukocyte Function-Associated Antigen-1 (LFA-1) with InterCellular Adhesion Molecule-1 (ICAM-1) vol.9, pp.7, 2014, https://doi.org/10.1371/journal.pone.0102572
  4. infection vol.145, pp.4, 2015, https://doi.org/10.1111/imm.12470
  5. Proteomics analysis of bodily fluids in pancreatic cancer vol.15, pp.15, 2015, https://doi.org/10.1002/pmic.201400476
  6. LPS Up-Regulates ICAM-1 Expression in Breast Cancer Cells by Stimulating a MyD88-BLT2-ERK-Linked Cascade, Which Promotes Adhesion to Monocytes vol.38, pp.9, 2015, https://doi.org/10.14348/molcells.2015.0174
  7. Inhibition of human colorectal cancer metastasis by notoginsenoside R1, an important compound from Panax notoginseng vol.37, pp.1, 2016, https://doi.org/10.3892/or.2016.5222
  8. Association of intercellular adhesion molecule-1 single nucleotide polymorphisms with hepatocellular carcinoma susceptibility and clinicopathologic development vol.37, pp.2, 2016, https://doi.org/10.1007/s13277-015-3992-z
  9. Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients vol.11, pp.3, 2017, https://doi.org/10.2217/bmm-2016-0246
  10. Role of liver ICAM-1 in metastasis vol.14, pp.4, 2017, https://doi.org/10.3892/ol.2017.6700
  11. Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta vol.47, pp.1, 2019, https://doi.org/10.1515/jpm-2018-0086
  12. Optical Imaging of Triple-Negative Breast Cancer Cells in Xenograft Athymic Mice Using an ICAM-1-Targeting Small-Molecule Probe pp.1860-2002, 2019, https://doi.org/10.1007/s11307-018-01312-3