Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Clinical Evaluation of Residual Effectiveness of Antibacterial Agents

항균성분의 지속력에 대한 인체적용 시험 평가

  • Received : 2012.11.12
  • Accepted : 2013.01.21
  • Published : 2013.06.30
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Abstract

This in vivo study via ASTM E2752-10, cup scrub method, was performed to evaluated the residual effectiveness of PCMX and IPMP commonly used in antibacterial soap. The liquid soap having 5% of PCMX and 0.1% of IPMP showed statistically significant reduction of E. coli and S. aurues as compared with control in a trial of 80 healthy volunteers. And its efficacy was maintained for 27 h at least. We report the result of residual effectiveness of antibacterial agents for the first time in Korea.

항균비누에 흔히 사용되는 항균성분인 PCMX와 IPMP에 대하여 ASTM E2752-10 (Standard Guide for Evaluation of Residual Effectiveness of Anti- bacterial Personal Cleansing Products)에 기술된 cup scrub method에 따라 항균 지속력을 평가하였다. 건강한 남녀 총 80명의 피험자를 대상으로 한 실험에서 5% PCMX와 0.1% IPMP를 함유한 액체비누는 대조군에 비해서 E. coli와 S. aureus의 수를 통계학적으로 유의하게 감소시켰으며 27시간 동안 항균효과가 지속되는 것을 확인하였다. 항균성분의 지속력에 대한 인체적용 시험은 국내에서는 처음 시행된 것으로 결과와 함께 보고하는 바이다.

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References

  1. L. C. Hadaway, Skin Flora and Infection, J. Infus. Nurs., 26(1), 44 (2003). https://doi.org/10.1097/00129804-200301000-00006
  2. C. Bangert, P. M. Brunner, and G. Stingl, Immune functions of the skin, Clin. Dermatol., 29(4), 360 (2011). https://doi.org/10.1016/j.clindermatol.2011.01.006
  3. F. P. Downes, Compendium of methods for the microbiological examination of food, ed. K. Ito, American Public Health Association Press, Washington, D. C. (2001).
  4. J. G. Holt, N. R. Krieg, P. H. A. Sneath, J. T. Staley, and S. T. Williams, Bergey's manual of determinative bacteriology, Lippincott Williams & Wilkins, Baltimore, M. D. (1994).
  5. K. A. N. Messingham, D. E. Faunce, and E. J. Kovacs, Alcohol, injury, and cellular immunity, Alcohol., 28(3), 137 (2002). https://doi.org/10.1016/S0741-8329(02)00278-1
  6. G. Germann, U. Barthold, R. Lefering, T. Raff, and B. Gartmann, The impact of risk factors and pre-existing conditions on the mortality of burn patients and the precision of predictive admission scoring system, Burns., 23(3), 195 (1997). https://doi.org/10.1016/S0305-4179(96)00112-X
  7. D. E. Faunce, M. S. Gregory, and E. J. Kovacs, Effects of acute ethanol exposure on cellular immune responses in a murine model of thermal injury, J. Leukoc. Biol., 62(6), 733 (1997). https://doi.org/10.1002/jlb.62.6.733
  8. S. N. Cohen, Skin Microbiology: Relevance to Clinical Infection, eds. H. I. Maibach and R. Aly, 329, Spinger-Vetlag, New York (1981).
  9. W. C. Noble, The Skin Microflora and Microbial Skin Disease, ed. W. C. Noble, 153, Cambridge University Press, Cambridge, U. K. (1992).
  10. Y. K. Park, G. Y. Jeong, M. H. Kim, J. A. Kim, and H. S. Kim, Characterization of coliform group isolates from drinking water, Rep. Busan Inst. Health & Environ., 14(1), 5 (2004).
  11. C. S. Park, G. S. Park, and M. L. Kim, Effect of Oregano (Origanum vulgare L.) on the survival of Escherichia coli O157:H7 and staphylococcus aureus 196E during cold storage, Korean J. Soc. Food., 13, 440 (1997).
  12. G. Kampf and A. Kramer, Epidemiologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs, Clin. Microbiol. Rev., 17(4), 863 (2004). https://doi.org/10.1128/CMR.17.4.863-893.2004
  13. A. E. Aiello and E. Larson, Antibacterial cleansing and hygiene products as an emerging risk factor for antibiotic resistance in the community, Lancet Infect. Dis., 3(8), 501 (2003). https://doi.org/10.1016/S1473-3099(03)00723-0
  14. S. B. Levy, Antibacterial household products: cause for concern, Emerg. Infect. Dis., 7(3), 512 (2001). https://doi.org/10.3201/eid0707.017705
  15. A. D. Russell, Mechanisms of bacterial insusceptibility to biocides, Am. J. Infect. Control., 29(4), 259 (2001). https://doi.org/10.1067/mic.2001.115671
  16. C. A. Bartzokas, J. E. Corkill, and T. Makin, Evaluation of the skin disinfecting activity and cumulative effect of chlohexidine and triclosan handwash preparations on hands artificially contaminated with Serratia marcescens, Infect. Control., 8(4), 163 (1987). https://doi.org/10.1017/S0195941700065838
  17. S. Luby, M. Agboatwalla, B. M. Schnell, R. M. Hoekstra, M. H. Rahbar, and B. M. Keswick, The effect of antibacterial soap on impetigo incidence, Karachi, Pakistan, Am. J. Top Med. Hyg., 67(4), 430 (2002). https://doi.org/10.4269/ajtmh.2002.67.430
  18. E. E. Sickbert-Bennett, D. J. Weber, M. F. Gergen- Teague, M. D. Sobsey, G. P. Samsa, and W. A. Rutala, Comparative efficacy of hand hygiene agents in the reduction of bacteria and virus, Am. J. Infect. Control., 33(2), 67 (2005). https://doi.org/10.1016/j.ajic.2004.08.005
  19. M. Braoudaki and A. C. Hilton, Low level of cross-resistance between triclosan and antibiotics in Escherichia coli K-12 and E. coli O55 compared to E. coli O157, FEMS Microbiol. Lett., 235(2), 305 (2004). https://doi.org/10.1111/j.1574-6968.2004.tb09603.x
  20. M. Braoudaki and A. C. Hilton, Adaptive resistance to biocides in Salmonella enterica and Escherichia coli O157 and cross-resistance to antimicrobial agents, J. Clin. Microbiol., 42(1), 73 (2004). https://doi.org/10.1128/JCM.42.1.73-78.2004
  21. M. T. Suller and A. D. Russell, Triclosan and antibiotic resistance in Staphylococcus aureus, J. Antimicrob. Chemother., 46(1), 11 (2000).
  22. J. J. Leyden and A. M. Kligman, Safety and Efficacy of Topical Drugs and Cosmetics, eds. J. J. Leyden and A. M. Kligman, 289, Grune & Stratton, New York (1982).
  23. R. N. Michaud, M. B. McGrath, and W. A. Goss, Application of a gloved hand model for multiparameter measurements of skin-degerming activity, J. Clin. Microbiol., 3(4), 406 (1976).
  24. M. Roter, W. Kobler, and G. Wewalka, Providoneiodine and chlorhexidine gluconate containing detergents for disinfection of hands, J. Hosp. Infect., 2(3), 273 (1981). https://doi.org/10.1016/0195-6701(81)90050-5
  25. J. L. Fuls, N. D. Rodgers, G. E. Fischler, J. M. Howard, M. Patel, P. L. Weidner, and M. H. Duran, Alternative hand contamination technique to compare the activities of antimicrobial and nonantimicrobial soaps under different test conditions, Appl. Environ. Microbiol., 74(12), 3739 (2008). https://doi.org/10.1128/AEM.02405-07
  26. M. Rotter, S. sattar, S. Dharan, B. Allegranzi, E. Mathai, and D. Pittet, Method to evaluated the microbicidal activities of hand-rub and hand-wash agents, J. Hosp. Infect., 73(3), 191 (2009). https://doi.org/10.1016/j.jhin.2009.06.024
  27. R. Aly and H. I. Maibach, In vivo methods for test ing topical antimicrobial agents, J. Soc. Cosmet. Chem., 32, 317 (1981).
  28. M. B. Finkey, N. C. Corbin, J. B. Aust, R. Aly, and H. I. Maibach, In vivo effect antimicrobial soap bars containing 1.5% and 0.8% trichlorocarbanilide against two strains of pathogenic bacteria, J. Soc. Cosmet. Chem., 35, 351 (1984).
  29. W. L. Billhimer, C. A. Berge, J. S. Englehart, G. Y. Rains, and B. H. Keswick, A modified cup scrub method for assessing the antibacterial substantivity of personal cleansing products, J. Cosmet. Sic., 53(6), 369 (2001).
  30. M. Burton, E. Cobb, P. Donachie, G. Judah, V. Curtis, and W.P. Schmidt, The effect of handwashing with water or soap on bacterial contamination of hands, Int. J. Environ. Res. Public. Health., 8(1), 97 (2011). https://doi.org/10.3390/ijerph8010097