Vitamin E, an Antioxidant, as a Possible Therapeutic Agent for Treating Pain

DOI QR Code

Jeon, Young Hoon (Department of Anesthesiology and Pain Medicine, School of Dentistry, Kyungpook National University)

Kim MJ, Hong BH, Zhang EJ, Ko YK, Lee WH. Antinociceptive effects of intraperitoneal and intrathecal vitamin E in the rat formalin test. Korean J Pain 2012; 25: 238-44. https://doi.org/10.3344/kjp.2012.25.4.238
Schwartz ES, Kim HY, Wang J, Lee I, Klann E, Chung JM, et al. Persistent pain is dependent on spinal mitochondrial antioxidant levels. J Neurosci 2009; 29: 159-68. https://doi.org/10.1523/JNEUROSCI.3792-08.2009
Park ES, Gao X, Chung JM, Chung K. Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons. Neurosci Lett 2006; 391: 108-11. https://doi.org/10.1016/j.neulet.2005.08.055
Kamal-Eldin A, Appelqvist LA. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 1996; 31: 671-701. https://doi.org/10.1007/BF02522884
van Dam PS, Bravenboer B, van Asbeck BS, Marx JJ, Gispen WH. High rat food vitamin E content improves nerve function in streptozotocin-diabetic rats. Eur J Pharmacol 1999; 376: 217-22. https://doi.org/10.1016/S0014-2999(99)00376-3
Kim HK, Kim JH, Gao X, Zhou JL, Lee I, Chung K, et al. Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain. Pain 2006; 122: 53-62. https://doi.org/10.1016/j.pain.2006.01.013

ACTION OF VITAMIN E ON EXPERIMENTAL SEVERE ACUTE LIVER FAILURE vol.54, pp.2, 2017, https://doi.org/10.1590/s0004-2803.201700000-03
The Antioxidant Properties of Selenium and Vitamin E; Their Role in Periparturient Dairy Cattle Health Regulation vol.10, pp.10, 2021, https://doi.org/10.3390/antiox10101555