The Korean Journal of Pain

  • 제26권3호
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  • Pages.242-248
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  • 2013
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
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Herpes Zoster Vaccination

  • Kim, Kyung Hoon (Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University)
  • 투고 : 2013.06.17
  • 심사 : 2013.06.20
  • 발행 : 2013.07.01
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초록

Varicella (chickenpox) is a highly contagious airborne disease caused by primary infection with the varicella zoster virus (VZV). Following the resolution of chickenpox, the virus can remain dormant in the dorsal sensory and cranial ganglion for decades. Shingles (herpes zoster [HZ]) is a neurocutaneous disease caused by reactivation of latent VZV and may progress to postherpetic neuralgia (PHN), which is characterized by dermatomal pain persisting for more than 120 days after the onset of HZ rash, or "well-established PHN", which persist for more than 180 days. Vaccination with an attenuated form of VZV activates specific T-cell production, thereby avoiding viral reactivation and development of HZ. It has been demonstrated to reduce the occurrence by approximately 50-70%, the duration of pain of HZ, and the frequency of subsequent PHN in individuals aged ${\geq}50$ years in clinical studies. However, it has not proved efficacious in preventing repeat episodes of HZ and reducing the severity of PHN, nor has its long-term efficacy been demonstrated. The most frequent adverse reactions reported for HZ vaccination were injection site pain and/or swelling and headache. In addition, it should not be administrated to children, pregnant women, and immunocompromised persons or those allergic to neomycin or any component of the vaccine.

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참고문헌

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피인용 문헌

  1. Medications in Treatment of Postherpetic Neuralgia vol.27, pp.1, 2014, https://doi.org/10.3344/kjp.2014.27.1.1
  2. Risk Factor and Prevention of Postherpetic Neuralgia vol.28, pp.3, 2015, https://doi.org/10.3344/kjp.2015.28.3.167
  3. Earlier treatment improves the chances of complete relief from postherpetic neuralgia vol.30, pp.3, 2017, https://doi.org/10.3344/kjp.2017.30.3.214
  4. The positive duration of varicella zoster immunoglobulin M antibody test in herpes zoster vol.95, pp.33, 2016, https://doi.org/10.1097/MD.0000000000004616
  5. Herpes zoster ophthalmicus associated with abducens palsy vol.5, pp.2, 2013, https://doi.org/10.4103/0976-3147.131673
  6. Chickenpox: An update vol.49, pp.1, 2013, https://doi.org/10.1016/j.medmal.2018.04.395
  7. Recombinant zoster vaccine (Shingrix®): a new option for the prevention of herpes zoster and postherpetic neuralgia vol.33, pp.3, 2013, https://doi.org/10.3344/kjp.2020.33.3.201
  8. Using the Past to Maximize the Success Probability of Future Anti-Viral Vaccines vol.8, pp.4, 2020, https://doi.org/10.3390/vaccines8040566