Journal of Cardiovascular Imaging

Korean Society of Echocardiography (한국심초음파학회)
권호 표지
DOI QR코드

DOI QR Code

EFFECTS OF LOW DOSE VERSUS HIGH DOSE STATIN THERAPY ON THE CHANGES OF ENDOTHELIAL FUNCTION AND CAROTID INTIMA-MEDIA THICKNESS IN PATIENTS WITH VARIANT ANGINA

  • Kim, Kye Hun (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Cho, Sook Hee (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Yim, Yi Rang (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Lee, Kyung Jin (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Yum, Ju Hyup (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Yoon, Hyun Ju (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Yoon, Nam Sik (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Hong, Young Joon (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Park, Hyung Wook (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Kim, Ju Han (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Ahn, Youngkeun (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Jeong, Myung Ho (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Cho, Jeong Gwan (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University) ;
  • Park, Jong Chun (The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences of Chonnam National University)
  • Received : 2013.02.27
  • Accepted : 2013.05.22
  • Published : 2013.06.27
⟨ Previous Next ⟩

Abstract

Background: To compare the effects of low dose and high dose of statin treatment on endothelial function and carotid intimamedia thickness (IMT) in patients with variant angina (VAP). Methods: A total of 70 patients with VAP were divided into two groups; atorvastatin 10 mg treatment group (group I: n = 35, $54.2{\pm}12.5$ years) versus atorvastatin 40 mg treatment group (group II: n = 35, $52.6{\pm}9.8$ years). Flow mediated vasodilation (FMD) of the brachial artery and IMT of the carotid artery were compared between the groups after 6 months of statin treatment. Results: The baseline FMD and carotid IMT were not different between the groups. After 6 months of statin therapy, FMD was significantly improved in both groups ($7.7{\pm}2.5%$ to $8.9{\pm}2.2%$ in group I, p = 0.001, $7.9{\pm}2.7%$ to $9.5{\pm}2.8%$ in group II, p < 0.001), but the degree of FMD change and FMD at 6 month were not different between the groups. Carotid IMT were not changed in both groups after 6 months of statin therapy. Conclusion: The use of statin for 6 months significantly improved endothelial function in patients with VAP, but carotid IMT was not changed. The use of high dose statin did not show significant additional benefit as compared with the use of low dose statin. The present study suggested that statin therapy would be beneficial in the treatment of VAP.

Keywords

Cited by

  1. Association of statin therapy with clinical outcomes in patients with vasospastic angina: Data from Korean health insurance review and assessment service vol.14, pp.1, 2013, https://doi.org/10.1371/journal.pone.0210498
  2. The effect of atorvastatin on the common carotid artery intima-media thickness in patients with ischemic stroke vol.59, pp.2, 2020, https://doi.org/10.20471/acc.2020.59.02.04