DOI QR코드

DOI QR Code

Relationship between Colonic Polyp Type and the Neutrophil/Lymphocyte Ratio as a Biomarker

  • 발행 : 2013.05.30

초록

Aim: We designed this study to investigate the neutrophil lymphocyte ratio as a biomarker in distinguishing colonic polyps which are neoplastic or non-neoplastic. Materials and Methods: One hundred and twenty-five patients with colonic polyps were enrolled into the study. The following data were obtained from a computerized patient registry database: mean platelet volume (MPV), uric acid (UA), platelet count (PC), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT) and the neutrophil to lymphocyte ratio (NLR). Exclusion criteria were active infectious disease, hematological disorders, and malignancies. Colonic polyps divided into two groups as neoplastic polyps (tubular adenoma, villous adenoma, tubulovillous adenoma) and non-neoplastic polyps (hyperplastic polyps, inflammatory pseudopolyps etc). The relationship between colonic polyp type and NLR was evaluated with statistical analysis. Results: There were 67 patients (53.6%) with neoplastic and 58 (46.4%) patients with non-neoplastic polyps. Mean NLRs of neoplastic and non-neoplastic groups were respectively $3.32{\pm}2.54$ and $2.98{\pm}3.16$ (P<0.05). Conclusion: Although sensitivity and specificity are not high, NLR may be used as a biomarker of neoplastic condition of colonic polyps.

키워드

참고문헌

  1. Al-Shaiba R, McMillan DC, Angerson WJ, et al (2004). The relationship between hypoalbuminaemia, tumour volume and the systemic inflammatory response in patients with colorectal liver metastases. Br J Cancer, 91, 205-7.
  2. An X, Ding PR, Li YH, et al (2010). Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer. Biomarkers, 15, 516-22. https://doi.org/10.3109/1354750X.2010.491557
  3. Cho H, Hur HW, Kim SW et al (2008). Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother, 58, 15-23.
  4. Chua W, Charles KA, Baracos VE, et al (2011). Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer. Br J Cancer, 104, 1288-95. https://doi.org/10.1038/bjc.2011.100
  5. Correa P (1979). Epidemiology of polyps and cancer in the human intestine. Gastroenterology, 77, 1245-51.
  6. Coussens LM, Werb Z (2002). Inflammation and cancer. Nature, 420, 860-7. https://doi.org/10.1038/nature01322
  7. Fenoglio CM, Pascal RR (1982). Colorectal adenomas and cancer: Pathologic relationships. Cancer, 50, 2601- 8.
  8. Halazun KJ, Aldoori A, Malik HZ, et al (2008). Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases. Eur J Surg Oncol, 34, 55-60. https://doi.org/10.1016/j.ejso.2007.02.014
  9. Imtiaz F, Shafique K, Mirza SS et al (2012). Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Archives of Med. 5, 2. https://doi.org/10.1186/1755-7682-5-2
  10. Ishizuka M, Nagata H, Takagi K, et al (2012). C-reactive protein is associated with distant metastasis of T3 colorectal cancer. Anticancer Res, 32, 1409-15.
  11. Konishi F, Morson BC (1982). Pathology of colorectal adenomas: A colonoscopic survey. J Clin Pathol, 35, 830-41. https://doi.org/10.1136/jcp.35.8.830
  12. Linton A, Zandwijk N, Reid G, Stephen Clarke et al (2012). Inflammation in malignant mesothelioma - friend or foe?. Ann Cardiothorasic Surg, 1, 516-22.
  13. Mc Millan DC, Canna K, Mc Ardle CS (2003). Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg, 90, 215-9. https://doi.org/10.1002/bjs.4038
  14. Morson BC (1966). Factors influencing the prognosis of early cancer of the rectum. Proc R Soc Med, 59, 607-8.
  15. Pages F, Berger A, Camus M, et al (2005). Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med, 353, 2654-66. https://doi.org/10.1056/NEJMoa051424
  16. Saito K, Kihara K (2010). Role of C-reactive protein as a biomarker for renal cell carcinoma. Expert Rev Anticancer Ther, 10, 1979-89 https://doi.org/10.1586/era.10.192
  17. Ubukata H, Motohashi G, Tabuchi T, et al (2010). Evaluations of interferon-$\gamma$/interleukin-4 ratio and neutrophil/lymphocyte ratio as prognostic indicators in gastric cancer patients. J Surg Oncol, 102, 742-7. https://doi.org/10.1002/jso.21725
  18. Ueno H, Hawrylowicz CM, Banchereau J (2007). Immunological intervention in human diseases. J Transl Med, 5, 59. https://doi.org/10.1186/1479-5876-5-59
  19. Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ (2005). Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol, 91, 181-4 https://doi.org/10.1002/jso.20329

피인용 문헌

  1. Variation of Blood T Lymphocyte Subgroups in Patients with Non- small Cell Lung Cancer vol.14, pp.8, 2013, https://doi.org/10.7314/APJCP.2013.14.8.4671
  2. Predictive Role of the Neutrophil Lymphocyte Ratio for Invasion with Gestational Trophoblastic Disease vol.15, pp.10, 2014, https://doi.org/10.7314/APJCP.2014.15.10.4203
  3. Is the Neutrophil-Lymphocyte Ratio an Indicator of Progression in Patients with Benign Prostatic Hyperplasia? vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6375
  4. Roles of Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios in the Early Diagnosis of Malignant Ovarian Masses vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6881
  5. Elevated Neutrophil-to-Lymphocyte Ratio in Squamous Cell Carcinoma of Larynx Compared to Benign and Precancerous Laryngeal Lesions vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7351
  6. Prevalence and Characteristics of Colorectal Polyps in Symptomatic and Asymptomatic Iranian Patients Undergoing Colonoscopy from 2009-2013 vol.15, pp.22, 2014, https://doi.org/10.7314/APJCP.2014.15.22.9933
  7. Has the Neutrophil/Lymphocyte Ratio a Predictive Role in Distinguishing Neoplastic Potential of Colonic Polyps? vol.15, pp.5, 2014, https://doi.org/10.7314/APJCP.2014.15.5.2393
  8. Evaluation of Inflammation Parameters in Philadelphia Negative Chronic Myeloproliferative Neoplasia Patients vol.16, pp.13, 2015, https://doi.org/10.7314/APJCP.2015.16.13.5159
  9. What are the Endoscopic and Pathological Characteristics of Colorectal Polyps? vol.16, pp.13, 2015, https://doi.org/10.7314/APJCP.2015.16.13.5163
  10. May the Neutrophil/Lymphocyte Ratio Be a Predictor in the Differentiation of Different Thyroid Disorders? vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3875
  11. Higher serum uric acid levels and advanced age are associated with an increased prevalence of colorectal polyps vol.3, pp.5, 2015, https://doi.org/10.3892/br.2015.487
  12. Combination of preoperative NLR, PLR and CEA could increase the diagnostic efficacy for I-III stage CRC vol.31, pp.5, 2017, https://doi.org/10.1002/jcla.22075
  13. Elevated Neutrophil-to-Lymphocyte Ratio in Metabolic Syndrome Is Associated with Increased Risk of Colorectal Adenoma vol.15, pp.8, 2017, https://doi.org/10.1089/met.2017.0041