DOI QR코드

DOI QR Code

Endostar Combined with Cisplatin Inhibits Tumor Growth and Lymphatic Metastasis of Lewis Lung Carcinoma Xenografts in Mice

  • Dong, Xiao-Peng (Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University) ;
  • Xiao, Tian-Hui (Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University) ;
  • Dong, Hong (Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University) ;
  • Jiang, Ning (Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University) ;
  • Zhao, Xiao-Gang (Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University)
  • 발행 : 2013.05.30

초록

Objective: To investigate the effects of endostar, a recombined humanized endostatin, plus cisplatin on the growth, lymphangiogenesis and lymphatic metastasis of the Lewis lung carcinoma (LLC) in mice. Methods: A tumor model were established in C57BL/6 mice by intravenious transplantation of LLC cells. Then the mice were randomized to receive administration with NS, endostar, cisplatin, or endostar plus cisplatin. After the mice were sacrificed, tumor multiplicity, tumor size and lymph node metastasis were assessed. Then the expression of vascular endothelial growth factor-c (VEGF-C) and podoplanin were determined by immunohistochemical staining. Results: Endostar plus cisplatin significantly suppressed tumor growth. lymphatic metastasis and prolonged survival time of the mice without obvious toxicity. The inhibition of lymphatic metastasis was associated with decreased microlymphatic vessel density (MLVD) and expression of VEGF-C. Conclusions: Endostar combined with cisplatin was more effective to suppress tumor growth and lymphatic metastasis than either agent alone. Thus this may provide a rational alternative for lung carcinoma treatment.

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참고문헌

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피인용 문헌

  1. Anti-Tumor Effect of a Novel Soluble Recombinant Human Endostatin: Administered as a Single Agent or in Combination with Chemotherapy Agents in Mouse Tumor Models vol.9, pp.9, 2014, https://doi.org/10.1371/journal.pone.0107823
  2. Clinical Application of Recombinant Human Endostatin in Postoperative Early Complementary Therapy on Patients with Non-small Cell Lung Cancer in Chinese Mainland vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.4013
  3. and cisplatin in physiological solution vol.17, pp.39, 2015, https://doi.org/10.1039/C5CP02688A
  4. Effect of Endostar combined with angiopoietin-2 inhibitor on malignant pleural effusion in mice vol.32, pp.1, 2015, https://doi.org/10.1007/s12032-014-0410-0
  5. C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance vol.10, pp.2, 2017, https://doi.org/10.1007/s12274-016-1324-2
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  9. Potential lymphangiogenesis therapies: Learning from current antiangiogenesis therapies-A review vol.38, pp.6, 2018, https://doi.org/10.1002/med.21496