Asian Pacific Journal of Cancer Prevention

  • 제14권5호
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  • Pages.2963-2966
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Infection with Opisthorchis viverrini and Use of Praziquantel among a Working-age Population in Northeast Thailand

  • Saengsawang, Phubet (Department of Epidemiology, Faculty of Public Health, Khon Kaen University) ;
  • Promthet, Supannee (Department of Epidemiology, Faculty of Public Health, Khon Kaen University) ;
  • Bradshaw, Peter (Department of Epidemiology, Faculty of Public Health, Khon Kaen University)
  • 발행 : 2013.05.30
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초록

Infection with Opisthorchis viverrini (OV) due to eating certain traditional freshwater fish dishes is the principal risk factor for cholangiocarcinoma in Northeast Thailand where the infection is endemic and the incidence of this form of primary liver cancer has been the highest in the world. This paper is the second report of a prospective research project to monitor the impacts of a national liver fluke control programme in a rural community of Northeast Thailand. A sample of 684 villagers aged 20-65 years completed an interview questionnaire and were tested for infection using the Kato thick smear technique. The questionnaire was designed for the exploration of associations between OV infection, previous treatment with praziquantel, and knowledge and beliefs about the drug. The data were analysed using descriptive statistics and multiple logistic regression. The overall prevalence of OV infection was 37.2% and was highest in the 20-35 year age group, in those with a university degree and in those employed in the government sector. As many as 91.8% reported eating fish dishes known to place them at risk of infection. In the multiple regression analysis, previous use of praziquantel and lack of knowledge about whether or not the drug has a protective effect against re-infection were the only factors related to OV infection ($OR_{adj}$= 2.31, 95%CI =1.40-3.79 and $OR_{adj}$= 1.95, 95%CI= 1.24-3.05). The findings were discussed in terms of the possibly unwise dependency on praziquantel as a primary element in a control programme.

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참고문헌

  1. Andrews RH, Sithithaworn P, Petney TN (2008). Opisthorchis viverrini: an underestimated parasite in the world. Trends in Parasitology, 24, 497-501. https://doi.org/10.1016/j.pt.2008.08.011
  2. Boonmars T, Srisawangwong T, Srirach P, et al (2007). Apoptosis- related gene expressions in hamsters re-infected with Opisthorchis viverrini and re-treated with praziquantel. Parasitol Res, 102, 57-62. https://doi.org/10.1007/s00436-007-0724-3
  3. Bureau of Epidemiology, Ministry of Public Health of Thailand (2008). Annual Epidemiological Surveillance Report, 122-3.
  4. Bureau of Epidemiology, Ministry of Public Health, Thailand (2009). Annual Epidemiological Surveillance Report, 128-9.
  5. Jongsuksuntigul P, Imsomboon T (1997). The impact of a decade long opisthorchiasis control program in northeastern, Thailand. Southeast Asian J Trop Med Public Health, 28, 551-7.
  6. Kaewpitoon N, Kaewpitoon SJ, Pengsaa P (2008). Opisthorchaisis in Thailand: Review and current status. World J Gastroenterol, 14, 2297-302. https://doi.org/10.3748/wjg.14.2297
  7. Kamsa-ard S, Wiangnon S, Suwanrungruang K, et al (2011). Trends in liver cancer incidence between 1985 and 2009, Khon Kaen, Thailand: Cholangiocarcinoma. Asian Pac J Cancer Prev, 12, 2209-13.
  8. Khuhaprema T, Srivatanakul P (2006). Cancer in Thailand. National Cancer Institute, 4, 37.
  9. Lovis L, Mak TK, Phongluxa K, et al (2012). Efficacy of praziquantel against Schistosoma mekongi and Opisthorchis viverrini: a randomized, single-blinded dose-comparison trial. PLoS Negl Trop Dis, 6, 1726. https://doi.org/10.1371/journal.pntd.0001726
  10. Melman SD, Steinauer ML, Cunningham C, et al (2009). Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni. PLoS Negl Trop Dis, 3, 504. https://doi.org/10.1371/journal.pntd.0000504
  11. Nithikathkul C, Wichmann O, Polseela P, et al (2004). Health behavior associated with Opisthorchis viverrini infection in Khukan district, Si Sa Ket Province, Thailand. Southeast Asian J Trop Med Public Health, 35, 309-12.
  12. Poomphakwaen K, Promthet S, Kamsa-ard S, et al (2009). Risk factors for cholangiocarcinoma in Khon Kaen, Thailand: a nested case-control study. Asian Pac J Cancer Prev, 10, 251-7.
  13. Prasongwatana J, Laummaunwai P, Boonmars T, Pinlaor S (2012). Viable metacercariae of Opisthorchis viverrini in northeastern Thai cyprinid fish dishes-as part of a rational program for control of O. viverrini-associated cholangiocarcinoma. Parasitol Res, 10, 3154-9.
  14. Pungpak S, Bunnag D, Harinasuta T (1985). Studies on the chemotherapy of human opisthorchiasis: effective dose of praziquantel in heavy infection. Southeast Asian J Trop Med Public Hlth, 16, 248-52.
  15. Pungpak S, Radomyos P, Radomyos B, et al (1998). Treatment of Opisthorchiasis viverrini and intestinal fluke infections with praziquantel. Southeast Asian J Trop Med Public Hlth, 29, 246-9
  16. Rangsin R, Mungthin M, Taamasri P, et al (2009). Incidence and risk factors of Opisthorchis viverrini infections in a rural community in Thailand. Am J Trop Med Hyg, 81, 152-5.
  17. Rhongbutsri P, Kitvatanachai S (2002). Survey of the fluke infection rate in Ban Khok Yai village, Khon Kaen, Thailand. J Trop Med Parasitol, 25, 76-8.
  18. Saengsawang P, Promthet S, Bradshaw P (2012). Prevalence of OV infection in Yasothon Province, Northeast Thailand. Asian Pacific J Cancer Prev, 13, 3399-402. https://doi.org/10.7314/APJCP.2012.13.7.3399
  19. Sithithaworn P, Andrews RH, Van De N, et al (2012). The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. Parasitology Int, 61, 10-6. https://doi.org/10.1016/j.parint.2011.08.014
  20. Sithithaworn P, Haswell–Elkins M (2003).Epidemiology of Opisthorchis viverrini. ActaTropica, 88, 187-94.
  21. Sirisinha, S, Tuti S, Tawatsin A, et al (1983). Attempts to induce protective immunity in hamsters against infection by a liver fluke of man (Opisthorchis viverrini). Parasitology, 86, 127-36. https://doi.org/10.1017/S0031182000057231
  22. Soukhathammavong P, Odermatt P, Sayasone S, et al (2011). Efficacy and safety of mefloquine, artesunate, mefloquine–artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, openlabel, phase 2 trial. Lancet Infect Dis, 11, 110-18. https://doi.org/10.1016/S1473-3099(10)70250-4
  23. Sripa B, Kaewkes S, Sithithaworn P, et al (2007). Liver fluke induces cholangiocarcinoma. PLoS Med, 4, 201. https://doi.org/10.1371/journal.pmed.0040201
  24. Sripa B, Brindley PJ, Mulvenna J, et al (2012). The tumorigenic liver fluke Opisthorchis viverrini-multiple pathways to cancer. Trends in Parasitol, 28, 395-407. https://doi.org/10.1016/j.pt.2012.07.006
  25. Supanvanich S, Supanvanich K, Pawabut P (1981). Field trial of praziquantel in human opisthorchiasis in Thailand. Southeast Asian J Trop Med Public Health, 12, 598-602.
  26. Upatham ES, Viyanant V, Brockelman WY, et al (1988). Rate of re-infection by Opisthorchis viverrini in an endemic northeast Thai community after chemotherapy. Int J Parasitol, 18, 643-9. https://doi.org/10.1016/0020-7519(88)90099-9
  27. Upatham ES, Viyanant V, Kurathong S et al (1984). Relationship between prevalence and intensity of Opisthorchis viverrini infection, and clinical symptoms and signs in a rural community in northeast Thailand. Bull World Health Organ, 62, 451-61.
  28. Watanapa P, Watanapa WB (2002). Liver fluke-associated cholangiocarcinoma. Br J Surg, 89, 962-70. https://doi.org/10.1046/j.1365-2168.2002.02143.x
  29. World Health Organisation (1991). Basic laboratory methods in medical parasitology. World Health Organisation, Geneva.
  30. World Health Organisation (2003). Adherence to long-term therapies: evidence for action. World Health Organisation, Geneva.

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  14. Control of Opisthorchis viverrini infection for cholangiocarcinoma prevention vol.110, pp.1, 2017, https://doi.org/10.1007/s13149-017-0544-8
  15. A Comprehensive Public Health Conceptual Framework and Strategy to Effectively Combat Cholangiocarcinoma in Thailand vol.10, pp.1, 2016, https://doi.org/10.1371/journal.pntd.0004293
  16. Elevated Levels of Urinary 8-oxodG Correlate with Persistent Periductal Fibrosis after Praziquantel Treatment in Chronic Opisthorchiasis vol.98, pp.6, 2018, https://doi.org/10.4269/ajtmh.17-0971
  17. Thinking beyond Opisthorchis viverrini for risk of cholangiocarcinoma in the lower Mekong region: a systematic review and meta-analysis vol.7, pp.1, 2018, https://doi.org/10.1186/s40249-018-0434-3
  18. Cohort profile: cholangiocarcinoma screening and care program (CASCAP) vol.15, pp.1, 2015, https://doi.org/10.1186/s12885-015-1475-7
  19. Uncooked fish consumption among those at risk of Opisthorchis viverrini infection in central Thailand vol.14, pp.1, 2019, https://doi.org/10.1371/journal.pone.0211540