Asian Pacific Journal of Cancer Prevention

  • 제14권5호
  • /
  • Pages.2765-2769
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Correlation between Magnifying Narrow-band Imaging Endoscopy Results and Organoid Differentiation Indicated by Cancer Cell Differentiation and its Distribution in Depressed-Type Early Gastric Carcinoma

  • Tatematsu, Hidezumi (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Miyahara, Ryoji (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Shimoyama, Yoshie (Department of Pathology and Clinical Laboratories, Nagoya University Graduate School of Medicine) ;
  • Funasaka, Kohei (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Ohno, Eizaburou (Department of Endoscopy, Nagoya University Hospital) ;
  • Nakamura, Masanao (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Kawashima, Hiroki (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Itoh, Akihiro (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Ohmiya, Naoki (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Hirooka, Yoshiki (Department of Endoscopy, Nagoya University Hospital) ;
  • Watanabe, Osamu (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Maeda, Osamu (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Ando, Takafumi (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Goto, Hidemi (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine)
  • 발행 : 2013.05.30
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초록

Background: A close association between patterns identified by magnifying narrow-band imaging (M-NBI) and histological type has been described. M-NBI patterns were also recently reported to be related to the mucin phenotype; however, detials remain unclear. Materials and Methods: We investigated the cellular differentiation of gastric cancer lesions, along with their mucosal distribution observed by M-NBI. Ninety-seven depressed-type early gastric cancer lesions (74 differentiated and 23 undifferentiated adenocarcinomas) were visualized by M-NBI. Findings were divided into 4 patterns based on abnormal microvascular architecture: a chain loop pattern (CLP), a fine network pattern (FNP), a corkscrew pattern (CSP), and an unclassified pattern. Mucin phenotypes were judged as gastric (G-type), intestinal (I-type), mixed gastric and intestinal (M-type), and null (N-type) based on 4 markers (MAC5AC, MUC6, MUC2, and CD10). The relationship of each pattern of microvascular architecture with organoid differentiation indicated by cancer cell differentiation and its distribution in each histological type of early gastric cancer was investigated. Results: All CLP and FNP lesions were differentiated. The cancer cell distribution showed organoid differentiation in 84.2% (16/19) and 61.1% (22/36) of the two types of lesions, respectively, and there was a significant difference from the unclassified pattern with organoid differentiation (p<0.001). Almost all (94.7%; 18/19) CSP lesions were undifferentiated, and organoid differentiation was observed in 72.2% (13/18). There was a significant difference from the unclassified pattern with organoid differentiation (p<0.05). Conclusions: Cellular differentiation and distribution are associated with microvascular architecture observed by M-NBI.

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참고문헌

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  2. Long-Term Outcomes after D2 Gastrectomy for Early Gastric Cancer: Survival Analysis of a Single-Center Experience in China vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7219
  3. Histological verification of the usefulness of magnifying endoscopy with narrow-band imaging for horizontal margin diagnosis of differentiated-type early gastric cancers pp.1436-3305, 2017, https://doi.org/10.1007/s10120-017-0734-5