Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Histopathology Analysis of Benign Colorectal Diseases and Colorectal Cancer in Hatyai Hospital, Songkhla, Thailand

  • Kotepui, Manas (Medical Technology Program, School of Allied Health Sciences and Public Health, Walailak University) ;
  • Piwkham, Duangjai (Medical Technology Program, School of Allied Health Sciences and Public Health, Walailak University) ;
  • Songsri, Apiram (Department of Pathology, Hatyai Hospital) ;
  • Charoenkijkajorn, Lek (Department of Pathology, Hatyai Hospital)
  • Published : 2013.04.30
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Abstract

Background: Colorectal cancer (CRC) is a major cause of morbidity and mortality in the western world and also ranks as the fifth-leading malignancy and death in Thailand. This study aimed to provide a present outlook of colorectal diseases among Thai patients with special emphasis on CRC in Hatyai, Songkhla, southern Thailand. Materials and Methods: This retrospective study covered ten year data of CRC, benign colorectal tumors and non-colorectal tumors from the Department of Pathology in Hatyai Hospital, Songkhla, Thailand, between years 2003-2012. Incidence rates based on age, gender, ten year incidence trends, and distribution of histopathological characteristics of patients were calculated and demonstrated. Results: Out of 730 biopsies, 100 cases were benign colorectal tumors, 336 were CRC and 294 were non-colorectal tumors. Colorectal tumors (both benign and CRC) (60.1%) were more common than non-colorectal tumors (39.9%). CRC (77.1%) were more common than benign colorectal tumors (32.9%). Colorectal tumors were mainly found in patients aged over sixty whereas non-colorectal and benign colorectal tumors were found in those under sixty (P=0.01). sAmong CRC, adenocarcinoma contributed about 97.3% of all cases with well differentiated tumors being the most frequent (56.9%). Both benign colorectal tumors and CRC were more commonly found in males (63%) than females (37%). The incidence trend of CRC demonstrated increase from 2003-2012. Conclusions: The incidence of CRC increased in Hatyai from 2003-2012. CRC tends to be more common in people older than sixty, thus, screening programs, cost-effective analysis of treatment modalities, and treatment protocols for the elderly should be examined. Proper implementation of preventive measures such as changing lifestyle factors might enhance control of colorectal disease.

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References

  1. Ahsan H, Neugut AI, Garbowski GC, et al (1998). Family history of colorectal adenomatous polyps and increased risk for colorectal cancer. Ann Intern Med, 128, 900-5. https://doi.org/10.7326/0003-4819-128-11-199806010-00006
  2. Atreya R, Neurath MF (2005). Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. Clin Rev Allergy Immunol, 28, 187-96. https://doi.org/10.1385/CRIAI:28:3:187
  3. Bernstein CN, Blanchard JF, Kliewer E, Wajda A (2001). Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer, 91, 854-62. https://doi.org/10.1002/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z
  4. Bussey HJR (1975). Familial polyposis coli: family studies, histopathology, differential diagnosis and results of treatment. Baltimore: Johns Hopkins University Press.
  5. Cappell MS, Forde KA (1989). Spatial clustering of multiple hyperplastic, adenomatous, and malignant colonic polyps in individual patients. Dis Colon Rectum, 32, 641-52. https://doi.org/10.1007/BF02555767
  6. Chan DS, Lau R, Aune D, et al (2011). Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS One, 6, 20456. https://doi.org/10.1371/journal.pone.0020456
  7. Chindaprasirt J, Sookprasert A, Wirasorn K, et al (2012). Cost of colorectal cancer care in hospitalized patients of Thailand. J Med Assoc Thai, 95, 196-200.
  8. Chong VH, Abdullah MS, Telisinghe PU, Jalihal A (2009). Colorectal cancer: incidence and trend in Brunei Darussalam. Singapore Med J, 50, 1085-9.
  9. Eaden JA, Abrams KR, Mayberry JF (2001). The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut, 48, 526-35. https://doi.org/10.1136/gut.48.4.526
  10. Ekbom A, Helmick C, Zack M, Adami HO (1990). Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med, 323, 1228-33. https://doi.org/10.1056/NEJM199011013231802
  11. Fantini MC, Pallone F (2008). Cytokines: from gut inflammation to colorectal cancer. Curr Drug Targets, 9, 375-80. https://doi.org/10.2174/138945008784221206
  12. Feik E, Baierl A, Hieger B, et al (2010). Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk. Cancer Causes Control, 21, 91-7. https://doi.org/10.1007/s10552-009-9438-4
  13. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
  14. Friedenreich C, Norat T, Steindorf K, et al (2006). Physical activity and risk of colon and rectal cancers: the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev, 15, 2398-407. https://doi.org/10.1158/1055-9965.EPI-06-0595
  15. Ghabeljoo M, Jafarabadi MA, Mohammadi SM, et al (2011). Patterns of survival for anatomical sites of colorectal cancer with shift to advanced lesions in Iran. Asian Pac J Cancer Prev, 12, 1225-31.
  16. Giovannucci E (2002). Modifiable risk factors for colon cancer. Gastroenterol Clin North Am, 31, 925-43.
  17. Grivennikov SI (2013). Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol, 35, 229-44. https://doi.org/10.1007/s00281-012-0352-6
  18. Hav M, Eav S, Ky V, et al (2011). Colorectal cancer in young Cambodians. Asian Pac J Cancer Prev, 12, 1001-5.
  19. Hiraoka S, Kato J, Fujiki S, et al (2010). The presence of large serrated polyps increases risk for colorectal cancer. Gastroenterology, 139, 1503-10, https://doi.org/10.1053/j.gastro.2010.07.011
  20. Ji BT, Devesa SS, Chow WH, Jin F, Gao YT (1998). Colorectal cancer incidence trends by subsite in urban Shanghai, 1972-1994. Cancer Epidemiol Biomarkers Prev, 7, 661-6.
  21. Kanemitsu Y, Kato T, Hirai T, et al (2003). Survival after curative resection for mucinous adenocarcinoma of the colorectum. Dis Colon Rectum, 46, 160-7. https://doi.org/10.1007/s10350-004-6518-0
  22. Khuhaprema T, Srivatanakul P (2008). Colon and rectum cancer in Thailand: an overview. Jpn J Clin Oncol, 38, 237-43. https://doi.org/10.1093/jjco/hyn020
  23. Larsson SC, Wolk A (2006). Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies. Int J Cancer, 119, 2657-64. https://doi.org/10.1002/ijc.22170
  24. Liang JJ, Bissett I, Kalady M, Bennet A, Church JM (2012). Importance of serrated polyps in colorectal carcinogenesis. ANZ J Surg, In press.
  25. Liu L, Lemmens VE, De Hingh IH, et al (2013). Second primary cancers in subsites of colon and rectum in patients with previous colorectal cancer. Dis Colon Rectum, 56, 158-68. https://doi.org/10.1097/DCR.0b013e318279eb30
  26. Lohsoonthorn P, Danvivat D (1995). Colorectal cancer risk factors: a case-control study in Bangkok. Asia Pac J Public Health, 8, 118-22. https://doi.org/10.1177/101053959500800211
  27. Longo R, Morabito A, Carillio G, et al (2006). Multiorganic dissemination of a colorectal signet ring cell carcinoma with fulminant clinical course. Int J Gastrointest Cancer, 37, 49-54. https://doi.org/10.1385/IJGC:37:1:49
  28. Nozoe T, Anai H, Nasu S, Sugimachi K (2000). Clinicopathological characteristics of mucinous carcinoma of the colon and rectum. J Surg Oncol, 75, 103-7. https://doi.org/10.1002/1096-9098(200010)75:2<103::AID-JSO6>3.0.CO;2-C
  29. O'Sullivan J, Risques RA, Mandelson MT, et al (2006). Telomere length in the colon declines with age: a relation to colorectal cancer? Cancer Epidemiol Biomarkers Prev, 15, 573-7. https://doi.org/10.1158/1055-9965.EPI-05-0542
  30. Risques RA, Lai LA, Brentnall TA, et al (2008). Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. Gastroenterology, 135, 410-8. https://doi.org/10.1053/j.gastro.2008.04.008
  31. Roessner A, Kuester D, Malfertheiner P, Schneider-Stock R (2008). Oxidative stress in ulcerative colitis-associated carcinogenesis. Pathol Res Pract, 204, 511-24. https://doi.org/10.1016/j.prp.2008.04.011
  32. Sachar DB (1994). Cancer in Crohn's disease: dispelling the myths. Gut, 35, 1507-8. https://doi.org/10.1136/gut.35.11.1507
  33. Sanchez NF, Stierman B, Saab S, et al (2012). Physical activity reduces risk for colon polyps in a multiethnic colorectal cancer screening population. BMC Res Notes, 5, 312. https://doi.org/10.1186/1756-0500-5-312
  34. Slattery ML (2004). Physical activity and colorectal cancer. Sports Med, 34, 239-52. https://doi.org/10.2165/00007256-200434040-00004
  35. Sonnenberg A, Genta RM (2012). Helicobacter pylori is a risk factor for colonic neoplasms. Am J Gastroenterol, 108, 208-15.
  36. Sriamporn S, Wiangnon S, Suwanrungruang K, et al (2007). Risk factors for colorectal cancer in northeast Thailand: lifestyle related. Asian Pac J Cancer Prev, 8, 573-7.
  37. Sriplung H, Wiangnon S, Sontipong S, Sumitsawan Y, Martin N (2006). Cancer incidence trends in Thailand, 1989-2000. Asian Pac J Cancer Prev, 7, 239-44.
  38. Triantafillidis JK, Nasioulas G, Kosmidis PA (2009). Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res, 29, 2727-37.
  39. Tsai CJ, Lu DK (1995). Small colorectal polyps: histopathology and clinical significance. Am J Gastroenterol, 90, 988-94.
  40. Tsong WH, Koh WP, Yuan JM, et al (2007). Cigarettes and alcohol in relation to colorectal cancer: the Singapore Chinese Health Study. Br J Cancer, 96, 821-7. https://doi.org/10.1038/sj.bjc.6603623
  41. Vucenik I, Stains JP (2012). Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann NY Acad Sci, 1271, 37-43. https://doi.org/10.1111/j.1749-6632.2012.06750.x
  42. Winther KV, Jess T, Langholz E, Munkholm P, Binder V (2004). Long-term risk of cancer in ulcerative colitis: a population-based cohort study from Copenhagen County. Clin Gastroenterol Hepatol, 2, 1088-95. https://doi.org/10.1016/S1542-3565(04)00543-9
  43. Wolin KY, Lee IM, Colditz GA, et al (2007). Leisure-time physical activity patterns and risk of colon cancer in women. Int J Cancer, 121, 2776-81. https://doi.org/10.1002/ijc.23009
  44. Zarchy TM, Ershoff D (1996). Risk of colorectal cancer in families of patients with adenomatous polyps. N Engl J Med, 334, 1339-40. https://doi.org/10.1056/NEJM199605163342016

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