Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Efficacy and Safety of Concomitant Chemoradiotherapy with Cisplatin and Docetaxel in Patients with Locally Advanced Squamous Cell Head and Neck Cancers

  • Baykara, Meltem (Department of Medical Oncology, Sakarya University Training and Research Hospital) ;
  • Buyukberber, Suleyman (Department of Medical Oncology, Gazi University Medical Faculty) ;
  • Ozturk, Banu (Gaziosmanpasa University Medical Faculty, Department of Medical Oncology) ;
  • Coskun, Ugur (Department of Medical Oncology, Gazi University Medical Faculty) ;
  • Unsal, Diclehan Kilic (Department of Radiation Oncology, Gazi University Medical Faculty) ;
  • Demirci, Umut (Department of Medical Oncology, Ankara Ataturk Training and Research Hospital) ;
  • Dane, Faysal (Department of Medical Oncology, Marmara University Medical Faculty) ;
  • Kaplan, Muhammet Ali (Department of Medical Oncology, Dicle University Medical Faculty) ;
  • Bora, Huseyin (Department of Radiation Oncology, Gazi University Medical Faculty) ;
  • Benekli, Mustafa (Department of Medical Oncology, Gazi University Medical Faculty)
  • Published : 2013.04.30
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Abstract

Background: Chemoradiation (CRT) using cisplatin-based regimens has become the standard of care in the treatment of squamous cell head and neck cancers (SCHNC). The impact of taxanes as radiosensitizing agents with concurrent CRT regimens is unknown. We therefore retrospectively evaluated the efficacy and tolerability of a weekly cisplatin+docetaxel combination with CRT in locally advanced SCHNC. Methods: Sixty-six patients with locally advanced SCHNC (39.4% stage IV, 53% stage III, and 7.6% stage II) were assessed retrospectively. Total radiation dose to the PTV of gross disease (primary and/or node) was 70 Gy/35 fractions, 5 fractions per week. Minimum doses of 60 Gy and 50 Gy were administered to PTVs of elective high risk and low risk disease, respectively. Chemotherapy (CT) consisted of weekly cisplatin (20 $mg/m^2$)+docetaxel (20 $mg/m^2$) concurrently with RT. Results: The median age of the patients was 58 years (range, 32-77). Objective response rate was 83.3%. The 2-year progression-free survival (PFS) and overall survival (OS) were 75.7% and 78.3%, respectively. The most common grade 3 and 4 toxicities were mucositis (36.4%), nausea and vomiting (12.1%), neutropenia (4.5%). Conclusion: Weekly cisplatin and docetaxel concurrent with RT for locally advanced SCHNC was found tolerable with high efficacy.

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References

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