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Evaluation of Renal Function Using the Level of Neutrophil Gelatinase-Associated Lipocalin is Not Predictive of Nephrotoxicity Associated with Cisplatin-Based Chemotherapy

  • Kos, F. Tugba (Department of Medical Oncology, Kahramanmaras Sutcu Imam University Faculty of Medicine) ;
  • Sendur, Mehmet Ali Nahit (Department of Medical Oncology, Ankara Numune Education and Research Hospital) ;
  • Aksoy, Sercan (Department of Medical Oncology, Hacettepe University Institute of Oncology) ;
  • Celik, Huseyin Tugrul (Department of Biochemistry, Fatih University Faculty of Medicine) ;
  • Sezer, Sevilay (Department of Biochemistry, Ankara Numune Education and Research Hospital) ;
  • Civelek, Burak (Department of Medical Oncology, Ankara Numune Education and Research Hospital) ;
  • Yaman, Sebnem (Department of Medical Oncology, Ankara Numune Education and Research Hospital) ;
  • Zengin, Nurullah (Department of Medical Oncology, Ankara Numune Education and Research Hospital)
  • 발행 : 2013.02.28

초록

Background: For early detection of renal damage during the usage of cisplatin based chemotherapy, changes in renal function should be monitored carefully. In recent years, neutrophil gelatinase-associated lipocalin, a small polypeptide molecule, has shown promise as a marker of acute renal failure. The aim of this present study was to assess possible risk prediction of cisplatin-induced nephrotoxicity using serum NGAL. Materials and Methods: A total of 34 consecutive patients with documented serum creatinine at least 24 hours before every cycle of cisplatin-based chemotherapy were included in the study. Demographic and medical data including age, performance status, tumor characteristics and comorbid diseases were collected from medical charts. Renal function was evaluated at least 48 hours before the treatment and at the end of the treatment based on the Modification of Diet in Renal Disease (MDRD) formula. Before and after cisplatin infusion serum NGAL levels were measured for the first and 3rd cycles of chemotherapy. Results: The median age of the study population was 54 (32-70) years. Fifteen patients (41.1%) were treated on an adjuvant basis, whereas 19 patients (58.9%) were treated for metastatic disease. There was no correlation of serum NGAL levels with serum creatinine (r=0.20, p=0.26) and MDRD (r=-0.12, p=0.50) and creatinine clearance-Cockcroft-Gault (r=-0.22, p=0.22) after cisplatin infusion at the end of the 3rd cycle of chemotherapy. Conclusions: In our study, serum NGAL levels were not correlated with the cisplatin induced nephrotoxicity. Further prospective studies are needed to conclude that serum NGAL level is not a good surrogate marker to predict early cisplatin induced nephrotoxicity.

키워드

참고문헌

  1. Asna N, Lewy H, Ashkenazi IE, et al (2005). Time dependent protection of amifostine from renal and hematopoietic cisplatin induced toxicity. Life Sci, 76, 1825-34. https://doi.org/10.1016/j.lfs.2004.09.028
  2. Gaspari F, Cravedi P, Mandala M, et al (2010). Predicting cisplatin-induced acute kidney injury by urinary neutrophil gelatinase-associated lipocalin excretion: a pilot prospective case-control study. Nephron Clin Pract, 115, 154-60. https://doi.org/10.1159/000312879
  3. Hanigan MH, Devarajan P (2003). Cisplatin nephrotoxicity: molecular mechanisms. Cancer Ther, 1, 47-61.
  4. Kjeldsen L, Bainton DF, Sengelov H, Borregaard No1994). Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood, 83, 799-807.
  5. Kuwabara T, Mori K, Mukoyama M, et al (2009). Urinary neutrophil gelatinase- associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons. Kidney Int, 75, 285-94. https://doi.org/10.1038/ki.2008.499
  6. Levey AS, Bosch JP, Lewis JB, et al (1999). A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med, 130, 461-70. https://doi.org/10.7326/0003-4819-130-6-199903160-00002
  7. Ling W, Zhaohui N, Ben H, et al (2008). Urinary IL-18 and NGAL as early predictive biomarkers in contrast-induced nephropathy after coronary angiography. Nephron Clin Pract, 108, 176-81. https://doi.org/10.1159/000117814
  8. Mishra J, Ma Q, Prada A, et al (2003). Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol, 14, 2534-43. https://doi.org/10.1097/01.ASN.0000088027.54400.C6
  9. Mishra J, Mori K, Ma Q, et al (2004). Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol, 24, 307-15. https://doi.org/10.1159/000078452
  10. Mohanram A, Toto R (2005). Measurement of kidney function. In 'Chronic Kidney Disease, Dialysis, and Transplantation. A Companion to Brenner and Rector's The Kidney'. Eds Pereira BJG, Sayegh MH, Blake PG. Philadelphia, Saunders pp.20-30.
  11. Parikh CR, Jani A, Mishra J, et al (2006). Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant, 6, 1639-45. https://doi.org/10.1111/j.1600-6143.2006.01352.x
  12. Perazella MA, Moeckel GW (2010). Nephrotoxicity from chemotherapeutic agents: clinical manifestations, pathobiology, and prevention/therapy. Semin Nephrol, 30, 570-81. https://doi.org/10.1016/j.semnephrol.2010.09.005
  13. Perrone RD, Madias NE, Levy AS (1992). Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem, 38, 1933-53.
  14. Shemesh O, Golbetz H, Kriss JP, Myers BD (1985). Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int, 28, 830-8. https://doi.org/10.1038/ki.1985.205
  15. Townsend DM, Deng M, Zhang L, Lapus MG, Hanigan MH (2003). Metabolism of cisplatin to a nephrotoxin in proximal tubule cells. J Am Soc Nephrol, 14, 1-10. https://doi.org/10.1097/01.ASN.0000042803.28024.92
  16. Wagener G, Jan M, Kim M, et al (2006). Association between increases in urinary neutrophil-associated lipocalin and acute renal dysfunction after adult cardiac surgery. Anesthesiology, 105, 485-91. https://doi.org/10.1097/00000542-200609000-00011

피인용 문헌

  1. Predictive Role of Neutrophil Gelatinase-Associated Lipocalin in Early Diagnosis of Platin-Induced Renal Injury vol.16, pp.2, 2015, https://doi.org/10.7314/APJCP.2015.16.2.407
  2. Effect of Silymarin Administration on Cisplatin Nephrotoxicity: Report from A Pilot, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial vol.29, pp.7, 2015, https://doi.org/10.1002/ptr.5345
  3. Urinary KIM-1 in children undergoing nephrotoxic antineoplastic treatment: a prospective cohort study vol.30, pp.12, 2015, https://doi.org/10.1007/s00467-015-3178-3
  4. HSP72 is an early biomarker to detect cisplatin and acetaminophen nephrotoxicity vol.22, pp.6, 2017, https://doi.org/10.1080/1354750X.2017.1315616
  5. Urine biomarkers of acute kidney injury in noncritically ill, hospitalized children treated with chemotherapy vol.64, pp.10, 2017, https://doi.org/10.1002/pbc.26538
  6. Urinary protein biomarkers of kidney injury in patients receiving cisplatin chemotherapy vol.243, pp.3, 2018, https://doi.org/10.1177/1535370217745302