Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-cancer Effects of Costunolide in Estrogen Receptor Positive MCF-7 Breast Cancer Cells

에스트로겐 수용체 양성 MCF-7 유방암 세포주에 대한 costunolide의 항암효과

  • Kim, Woon Ji (Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Choi, Youn Kyung (Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Woo, Sang Mi (Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Park, Nam Gyu (Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Jung, Hye In (Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Yong Gook (Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Shin, Yong Cheol (Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Ko, Seong Gyu (Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University)
  • 김운지 (경희대학교 한의과대학 예방의학교실) ;
  • 최윤경 (경희대학교 한의과대학 예방의학교실) ;
  • 우상미 (경희대학교 한의과대학 예방의학교실) ;
  • 박남규 (경희대학교 한의과대학 예방의학교실) ;
  • 정혜인 (경희대학교 한의과대학 예방의학교실) ;
  • 김용국 (경희대학교 한의과대학 예방의학교실) ;
  • 신용철 (경희대학교 한의과대학 예방의학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실)
  • Received : 2012.11.26
  • Accepted : 2013.05.28
  • Published : 2013.06.25
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Abstract

Costunolide ($C_{15}H_{20}O_2$) is a sesquiterpene lactone that was isolated from many herbal medicines and it has diverse effects (anti-viral, anti-fungal, and anti-inflammatory) according to previous reports. However, the anti-cancer effects of Costunolide and its mechanism of actions are not well known in estrogen receptor positive breast cancer. In this study, we observed that costunolide suppresses cell growth in estrogen receptor positive MCF-7 breast cancer cells as shown by MTT assay and soft agar colony formation assay. To examine the mechanism by which costunolide inhibits MCF-7 cell growth, we performed FACS analysis. We found that costunolide induced G2/M and S cell cycle arrest, and regulated cycle-related protein expression. In addition, costunolide inhibited ERK signaling pathway and induced autophagy. Therefore, costunolide might be a good and useful chemotherapy agent for estrogen receptor positive breast cancer patients.

Keywords

References

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