Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Anti-Oxidative and Anti-Inflammatory Activities of Seven Medicinal Herbs including Tetrapanax papyriferus and Piper longum Linne

통초, 필발을 포함한 7종 한약재 추출물의 항산화 및 항염증 활성

  • Jin, Kyong-Suk (Blue-Bio Industry Regional Innovation Center, Dong-Eui University) ;
  • Oh, You Na (Blue-Bio Industry Regional Innovation Center, Dong-Eui University) ;
  • Lee, Ji Young (Blue-Bio Industry Regional Innovation Center, Dong-Eui University) ;
  • Son, Byung Yil (Blue-Bio Industry Regional Innovation Center, Dong-Eui University) ;
  • Choi, Woobong (Blue-Bio Industry Regional Innovation Center, Dong-Eui University) ;
  • Lee, Eun-Woo (Blue-Bio Industry Regional Innovation Center, Dong-Eui University) ;
  • Kwon, Hyun Ju (Blue-Bio Industry Regional Innovation Center, Dong-Eui University) ;
  • Kim, Byung Woo (Blue-Bio Industry Regional Innovation Center, Dong-Eui University)
  • 진경숙 (동의대학교 블루바이오소재개발 및 실용화 지원센터) ;
  • 오유나 (동의대학교 블루바이오소재개발 및 실용화 지원센터) ;
  • 이지영 (동의대학교 블루바이오소재개발 및 실용화 지원센터) ;
  • 손병일 (동의대학교 블루바이오소재개발 및 실용화 지원센터) ;
  • 최우봉 (동의대학교 블루바이오소재개발 및 실용화 지원센터) ;
  • 이은우 (동의대학교 블루바이오소재개발 및 실용화 지원센터) ;
  • 권현주 (동의대학교 블루바이오소재개발 및 실용화 지원센터) ;
  • 김병우 (동의대학교 블루바이오소재개발 및 실용화 지원센터)
  • Received : 2012.07.27
  • Accepted : 2013.04.16
  • Published : 2013.06.28
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Abstract

In this study, we analyzed the anti-oxidative and anti-inflammatory activities of seven medicinal herbs. All extracts of the tested herbs, Euryale ferox Salisbury, Echinops setifer Iljin, Amomum cardamomum Linne, Tetrapanax papyriferus, Illicium verum Hook. f., Typha orientalis Presl, and Piper longum Linne, exhibited potent anti-oxidative activity as confirmed by DPPH radical scavenging capacity. Lipopolysaccharide (LPS) induced nitric oxide (NO) production, in the RAW 264.7 cell line, was also ameliorated by all extracts' treatments in a dose dependent manner. NO suppressive activity originated from the inhibition of inducible nitric oxide synthase (iNOS) protein expression by the extracts. Three extracts, E. ferox S., I. verum Hook. f., and P. longum L., possessed suppressive activity against, not only iNOS, but also cycloxygenase 2 (COX-2) protein expression. These three extracts may then serve as potential candidates for non steroidal analgesic inflammation drugs (NSAIDs). Furthermore, all extracts induced anti-oxidative enzyme, heme oxygenase 1, protein expression. Taken together, these results provide an important new insight into the fact that various medicinal herbs possess potent anti-oxidative and anti-inflammatory activities and might be utilized as promising agents in the field of health products. Further studies for the identification of the active compounds from medicinal herbs are clearly needed.

Keywords

References

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